Coenzyme Q10 and α-tocopherol reversed age-associated functional impairments in mice

Shetty, Ritu A.; Ikonne, Uzoma; Forster, Michael J.; Sumien, Nathalie

doi:10.1016/j.exger.2014.08.007

Cited by 29 publications

(22 citation statements)

References 41 publications

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“…Coenzyme Q10 is a supplemental factor for impaired energy metabolism and is therefore considered suitable for use in the treatment of cardiac, neurologic, oncologic and immunologic diseases (5) . Coenzyme Q10 exerts positive effects on the memory and learning functions; however, studies reporting these data were conducted to evaluate learning functions in adults and postmenopausal women (6,8) . As a result of the recovery of the mitochondrial electron transport system due to CoQ10 replacement cognitive functions improved in experimental models of Alzheimer's disease and Parkinson's disease (9,10) .…”

Section: Discussionmentioning

confidence: 99%

Effect of Coenzyme Q10 replacement on learning and memory performance in young rats.

Polat¹,

Erol²,

Gayret³

et al. 2018

BUCH

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Objective: Coenzyme Q10 (CoQ10) administration is known to increase CoQ10 concentrations in the mitochondria of brain cells and facilitate the memory and learning processes in rats. This study aims to evaluate the effects of CoQ10 treatment on learning and memory functions in rat pups during early stages of development. Methods: A total of 21-day-old 24 pups were divided into 3 groups (8 pups in each group). A low dose of CoQ10 was administered via oral gavage once per day to one group, a high dose was administered to another group, and olive oil was administered to the control group. The cognitive and learning functions of rats in these groups were evaluated by the Morris water maze and probe tests. Results: Coenzyme Q10 administration was continued for 10 days. At the end of the 37 th day, the water maze test was used to evaluate learning and memory performance. No difference was observed in the test results among the high-dose, low-dose and control groups during the 5 days of training in the water maze test (p>0.05). Data from the probe trial indicated no statistically significant differences among rats that received high-, or low-dose CoQ10 or olive oil (control) (p=0.853). Conclusion: In our study, it was determined that administration of high-, or low-dose CoQ10 during childhood does not have a significant effect on learning and memory functions.

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Section: Discussionmentioning

confidence: 99%

Effect of Coenzyme Q10 replacement on learning and memory performance in young rats.

Polat¹,

Erol²,

Gayret³

et al. 2018

BUCH

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“…Wild type and 5 X FAD female mice were switched to diets containing MB or vehicle at the age of 8 weeks and continually fed for 8 months. At the age of 10 months, the mice were subjected to batteries of behavioral testing of water-maze and bridge walking as described previously (Shetty et al , 2014). MB diet group had significantly reduced average latency to fall in the bridge walking test as compared to control diet group (A).…”

Section: Figurementioning

confidence: 99%

Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots

Yang

Sumien

et al. 2017

Progress in Neurobiology

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Brain has exceptional high requirement for energy metabolism with glucose as the exclusive energy source. Decrease of brain energy metabolism and glucose uptake has been found in patients of Alzheimer’s, Parkinson’s and other neurodegenerative diseases, providing a clear link between neurodegenerative disorders and energy metabolism. On the other hand, cancers, including glioblastoma, have increased glucose uptake and rely on aerobic glycolysis for energy metabolism. The switch of high efficient oxidative phosphorylation to low efficient aerobic glycolysis pathway (Warburg effect) provides macromolecule for biosynthesis and proliferation. Current research indicate that methylene blue, a century old drug, can receive electron from NADH in the presence of complex I and donates it to cytochrome C, providing an alternative electron transfer pathway. Methylene blue increases oxygen consumption, decrease glycolysis, and increases glucose uptake in vitro. Methylene blue enhances glucose uptake and regional cerebral blood flow in rats upon acute treatment. In addition, methylene blue provides protective effect in neuron and astrocyte against various insults in vitro and in rodent models of Alzheimer’s, Parkinson’s, and Huntington’s disease. In glioblastoma cells, methylene blue reverses Warburg effect by enhancing mitochondrial oxidative phosphorylation, arrests glioma cell cycle at s-phase, and inhibits glioma cell proliferation. Accordingly, methylene blue activates AMP-activated protein kinase, inhibits downstream acetyl-coA carboxylase and cyclin-dependent kinases. In summary, there is accumulating evidence providing a proof of concept that enhancement of mitochondrial oxidative phosphorylation via alternative mitochondrial electron transfer may offer protective action against neurodegenerative diseases and inhibit cancers proliferation.

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“…However, it is important to highlight that differences in studies may explain the disparities in outcomes, and the lack of translation in randomized clinical trials (RCTs). In rodents, differential outcomes may be explained by the use of different isoforms of α-tocopherol (synthetic (Sumien et al 2004) vs. natural (Shetty et al 2014)), and by the age at which the supplementation was started. Indeed, when vitamin E is introduced in younger subjects and maintained into advanced age, improvements in cognitive and motor performance as well as decrease in oxidative stress were observed (Joseph et al 1998); however senescence-initiated vitamin E supplementation did not reverse oxidative damage or improve brain function (Sumien et al 2004).…”

Section: Antioxidant Intake and Moderate Exercise As Interventionsmentioning

confidence: 99%

“…Even combinations of just two or three antioxidants have led to increased beneficial outcomes on learning and to decreased oxidative stress (McDonald et al 2005; Shetty et al 2014) when compared to each antioxidant alone. The basic rationale for combining vitamin E and vitamin C stems from their different mechanisms and loci of action, and their interaction within a redox network.…”

Section: Antioxidant Intake and Moderate Exercise As Interventionsmentioning

confidence: 99%

The influence of vitamins E and C and exercise on brain aging

Mock

Chaudhari

Sidhu

et al. 2017

Experimental Gerontology

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Age-related declines in motor and cognitive function have been associated with increases in oxidative stress. Accordingly, interventions capable of reducing the oxidative burden would be capable of preventing or reducing functional declines occurring during aging. Popular interventions such as antioxidant intake and moderate exercise are often recommended to attain healthy aging and have the capacity to alter redox burden. This review is intended to summarize the outcomes of antioxidant supplementation (more specifically of vitamins C and E) and exercise training on motor and cognitive declines during aging, and on measures of oxidative stress. Additionally, we will address whether co-implementation of these two types of interventions can potentially further their individual benefits. Together, these studies highlight the importance of using translationally-relevant parameters for interventions and to study their combined outcomes on healthy brain aging.

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Coenzyme Q10 and α-tocopherol reversed age-associated functional impairments in mice

Cited by 29 publications

References 41 publications

Effect of Coenzyme Q10 replacement on learning and memory performance in young rats.

Effect of Coenzyme Q10 replacement on learning and memory performance in young rats.

Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots

The influence of vitamins E and C and exercise on brain aging

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