Coenzyme Q10 and Utility in Heart Failure: Just Another Supplement?

Oleck, Sylvia; Ventura, Héctor O.

doi:10.1007/s11897-016-0296-6

Cited by 18 publications

(25 citation statements)

References 41 publications

(51 reference statements)

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“…Levels of CoQ10 tend to decline with age, and deficiency has been associated with diseases such as HF. In fact, a close positive correlation between HF severity and severity of CoQ10 deficiency has been identified (Oleck & Ventura, 2016). It has been proposed that the antioxidant and free radical scavenging properties of CoQ10 are important in combatting harmful effects from the high ROS observed in HF patients (Sharma, Fonarow et al, 2016).…”

Section: Mitochondrial-targeted Antioxidantsmentioning

confidence: 98%

“…It has been proposed that the antioxidant and free radical scavenging properties of CoQ10 are important in combatting harmful effects from the high ROS observed in HF patients (Sharma, Fonarow et al, 2016). Furthermore, the vital role of CoQ10 in oxidative phosphorylation suggests that ATP generation may be directly enhanced via CoQ10 supplementation (Oleck & Ventura, 2016).…”

Section: Mitochondrial-targeted Antioxidantsmentioning

confidence: 99%

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Cardiac metabolism — A promising therapeutic target for heart failure

Noordali

Loudon

Frenneaux

et al. 2018

Pharmacology & Therapeutics

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Both heart failure with reduced ejection fraction (HFrEF) and with preserved ejection fraction (HFpEF) are associated with high morbidity and mortality. Although many established pharmacological interventions exist for HFrEF, hospitalization and death rates remain high, and for those with HFpEF (approximately half of all heart failure patients), there are no effective therapies. Recently, the role of impaired cardiac energetic status in heart failure has gained increasing recognition with the identification of reduced capacity for both fatty acid and carbohydrate oxidation, impaired function of the electron transport chain, reduced capacity to transfer ATP to the cytosol, and inefficient utilization of the energy produced. These nodes in the genesis of cardiac energetic impairment provide potential therapeutic targets, and there is promising data from recent experimental and early-phase clinical studies evaluating modulators such as carnitine palmitoyltransferase 1 inhibitors, partial fatty acid oxidation inhibitors and mitochondrial-targeted antioxidants.Metabolic modulation may provide significant symptomatic and prognostic benefit for patients suffering from heart failure above and beyond guideline-directed therapy, but further clinical trials are needed.

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Section: Mitochondrial-targeted Antioxidantsmentioning

confidence: 98%

Section: Mitochondrial-targeted Antioxidantsmentioning

confidence: 99%

Cardiac metabolism — A promising therapeutic target for heart failure

Noordali

Loudon

Frenneaux

et al. 2018

Pharmacology & Therapeutics

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“…Reduced levels of CoQ10 in the aging and those with DM have been reported [18]. CoQ10 supplementation influences the cholinergic system and protects cholinergic neurons in patients with Alzheimer’s disease [19-21], as well as improving cardiovascular function [22]. In addition, CoQ10 can reduce hyperglycemia [23-25], thereby protecting against endothelial abnormalities and dysfunction in DM [24] and reducing oxidative stress [24, 26].…”

Section: Introductionmentioning

confidence: 99%

Influence of Chronic Coenzyme Q10 Supplementation on Cognitive Function, Learning, and Memory in Healthy and Diabetic Middle-Aged Rats

2018

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Diabetes mellitus can induce impairment in learning and memory. Cognitive and memory deficits are common in older adults and especially in those with diabetes. This is mainly because of hyperglycemia, oxidative stress, and vascular abnormalities. Coenzyme Q10 (CoQ10) can decrease oxidative stress, hyperglycemia, and inflammatory markers, and improve vascular function. Therefore, the aim of the present study was to investigate the possible effects of CoQ10 on cognitive function, learning, and memory in middle-aged healthy and diabetic rats. Adult middle-aged male Wistar rats (390–460 g, 12–13 months old) were divided into 6 experimental groups. Diabetes was induced by a single i.p. injection of streptozotocin (60 mg/kg). CoQ10 (20 or 120 mg/kg, orally by gavage) was administered for 45 days. The cognitive function and learning memory of rats were evaluated using novel object recognition (NOR) and passive avoidance tests. The discrimination index of the NOR test in the diabetic groups receiving CoQ10 (20 or 120 mg/kg) and the healthy group receiving CoQ10 (120 mg/kg) was significantly higher than that in the control group. In addition, the step through latency was significantly longer and the time spent in the dark compartment was significantly shorter in the diabetic groups receiving CoQ10 than in the control group. CoQ10 supplementation can improve learning and memory deficits induced by diabetes in older subjects. In addition, CoQ10 at higher doses can improve cognitive performance in older healthy subjects.

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“…Patients with worsening symptoms and left ventricular dysfunction tend to have lower CoQ10 levels, and administration of CoQ10 seems to improve left ventricular function. 3 Finally, a systematic review recently demonstrated that in 3 randomized control trials, micronutrient repletion improved ejection fraction and quality of life in patients with heart failure. 4 This patient presented with new systolic heart failure and responded to repletion of various micronutrients and vitamins.…”

Section: Discussionmentioning

confidence: 99%

The Malnourished Heart: An Unusual Case of Heart Failure

Bruera

Kalakota

Balasubramanyam

2017

The American Journal of Medicine

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A 66-year-old woman with no past medical history was admitted for 3 months of worsening dyspnea, lower extremity edema, and orthopnea. She was not taking medications or supplements. She denied chest pain, recent infections, fevers, toxin exposures, or use of drugs or alcohol. She reported patchy hair loss on her scalp, bruises on her lower extremities, gingival bleeding, and burning of her lower extremities. All these symptoms appeared to have started within the previous year. She said that her diet during the past 2 years had consisted solely of processed cheese chips and vanilla cake. Her physical examination was notable for body mass index of 17, temporal wasting, and patchy hair loss. Her oral cavity revealed friable and hypertrophied gingivae along with severe periodontal disease (Figure). She had elevated jugular venous distention, pulmonary crackles bilaterally, and lower extremity edema. The skin was notable for bilateral lower extremity ecchymoses and nail dystrophy. The vital signs were normal. Labs were significant for hemoglobin of 10.3 g/dL with mean corpuscular volume of 103 fL. Her electrocardiogram showed no signs of active or previous ischemia. A transthoracic echocardiogram demonstrated global hypokinesis and left ventricular ejection fraction (LVEF) <20%. Her nuclear stress test was not consistent with ischemia. Evaluation of her serum vitamin levels showed she was deficient in Vitamins B1 (thiamine), B6, C, and D. The patient refused all medications. We administered thiamine, vitamin D, vitamin B12 injections, and multivitamin tablets. The patient was counseled to consume a balanced diet. After 3 months, the LVEF had improved to 50%. The hemoglobin improved to 13.3. Her heart failure symptoms had resolved completely. Her periodontal disease improved. Her final diagnosis was nonischemic cardiomyopathy with hypovitaminosis.

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Coenzyme Q10 and Utility in Heart Failure: Just Another Supplement?

Cited by 18 publications

References 41 publications

Cardiac metabolism — A promising therapeutic target for heart failure

Cardiac metabolism — A promising therapeutic target for heart failure

Influence of Chronic Coenzyme Q10 Supplementation on Cognitive Function, Learning, and Memory in Healthy and Diabetic Middle-Aged Rats

The Malnourished Heart: An Unusual Case of Heart Failure

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