Coenzyme Q10 – A new player in the treatment of heart failure?

Abstract

Coenzyme Q10 is the only endogenously synthesized lipid with a redox function which exhibits broad tissue and intracellular distribution in mammals. Beneficial effects of Coenzyme Q10 supplementation were observed in several age-related diseases including heart failure. CoQ10 (coenzyme Q10) level is significantly decreased in patients with this disease, which correlates with severity of clinical symptoms. Supplementation with various pharmaceutical formulations of CoQ10 improves impaired cardiac function and clinical course of heart failure. Current data from clinical trials indicate that CoQ10 can significantly reduce morbidity and mortality of heart failure patients in addition to guideline recommended pharmacotherapy.

Comparative analysis of minor bioactive constituents (CoQ10, tocopherols and phenolic compounds) in Arbequina extra virgin olive oils from Brazil and Spain

“…Another minor compound with great value is the coenzyme Q10 (CoQ 10 ), an endogenous lipophilic compound that is involved in essential cell regulations and modulations, mainly in the mitochondrial respiratory chain (Jankowski et al, 2016;Thanatuksorn et al, 2009). In the body it exists in either oxidized (ubiquinone) or reduced form (ubiquinol); mainly in its reduced form it is recognized as an effective endogenous antioxidant, although an antioxidant role of the oxidized form cannot be discarded (Pravst et al, 2010;Jankowski et al, 2016).…”

“…In the body it exists in either oxidized (ubiquinone) or reduced form (ubiquinol); mainly in its reduced form it is recognized as an effective endogenous antioxidant, although an antioxidant role of the oxidized form cannot be discarded (Pravst et al, 2010;Jankowski et al, 2016). Additionally, it has the ability to recycle α-tocopherol by sparing or regeneration (Pyo, 2010).…”

“…Therefore, the functions of CoQ 10 are not affected by the form in which it is consumed (Pravst et al, 2010). Most of the CoQ 10 in the human body is from endogenous synthesis, but levels decline progressively with increasing age and should be replaced daily by nourishment (Jankowski et al, 2016). In this sense, the EVOO consumption may be a dietary natural source for increasing intake of CoQ 10 (Venegas et al, 2011;Žmitek et al, 2014).…”

“…In this sense, the EVOO consumption may be a dietary natural source for increasing intake of CoQ 10 (Venegas et al, 2011;Žmitek et al, 2014). A wide range of possible benefits for human health has been reported for CoQ 10 (Pravst et al, 2010;Jankowski et al, 2016;Turunen et al, 2004). The levels of these minor bioactive constituents are variable in EVOO.…”

Cellular factories for coenzyme Q10 production

“…These diseases may manifest in conditions such as central nervous system (CNS) dysfunction, myopathy or cardiomyopathy, among others [19–22]. The oxidative damage associated with impaired CoQ 10 function has also been implicated in numerous clinical phenotypes [18, 23–25]. …”