Coenzyme Complex Decreased Cardiotoxicity When Combined with Chemotherapy in Treating Elderly Patients with Gastrointestinal Cancer

Zhang, Haiyan; Lu, Xiang

doi:10.7314/apjcp.2015.16.9.4045

Cited by 3 publications

(3 citation statements)

References 48 publications

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“…This substance decreases cardiotoxicity by enhancement of mitochondrial energy production, cell membrane stabilization, and beneficial effects on the metabolism of long-chain fatty acids. More data need to be collected to verify and confirm the clinical use of the coenzyme complex [ 141 ]. Moreover, it is described that calcitriol has a protective effect on organ damage after 5-FU administration; however, the function of the substance remains unclear [ 142 ].…”

Section: Management Of Fluoropyrimidine Cardiotoxicitymentioning

confidence: 99%

Cardiotoxicity of Fluoropyrimidines: Epidemiology, Mechanisms, Diagnosis, and Management

Jurczyk

Król

Midro

et al. 2021

JCM

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Cancer is a growing public health problem; it is responsible annually for millions of deaths worldwide. Fluoropyrimidines are highly effective and commonly prescribed anti-neoplastic drugs used in a wide range of chemotherapy regimens against several types of malignancies. 5-fluorouracil and its prodrugs affect neoplastic cells in multiple ways by impairing their proliferation, principally through the inhibition of thymidylate synthase. Fluoropyrimidine-induced cardiotoxicity was described more than 50 years ago, but many details such as incidence, mechanisms, and treatment are unclear and remain disputed. Severe cardiotoxicity is not only life-threatening, but also leads to withdrawal from an optimal chemotherapy regimen and decreases survival rate. Differences in the frequency of cardiotoxicity are explained by different chemotherapy schedules, doses, criteria, and populations. Proposed pathophysiological mechanisms include coronary vasospasm, endothelial damage, oxidative stress, Krebs cycle disturbances, and toxic metabolites. Such varied pathophysiology of the cardiotoxicity phenomenon makes prevention and treatment more difficult. Cardiovascular disturbances, including chest pain, arrhythmias, and myocardial infarction, are among the most common side effects of this class of anti-neoplastic medication. This study aims to summarize the available data on fluoropyrimidine cardiotoxicity with respect to symptoms, incidence, metabolism, pathophysiological mechanism, diagnosis, management, and resistance.

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Section: Management Of Fluoropyrimidine Cardiotoxicitymentioning

confidence: 99%

Cardiotoxicity of Fluoropyrimidines: Epidemiology, Mechanisms, Diagnosis, and Management

Jurczyk

Król

Midro

et al. 2021

JCM

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“…In a 54-patient study by Zhang et al, coenzyme complex was found to decrease cardiotoxicity when combined with chemotherapy in treating elderly patients with gastrointestinal cancer. [91] Coenzyme complex was postulated to confer cardioprotection through cell membrane stabilisation, enhanced mitochondrial energy production, antioxidant action and favourable effects on metabolism of long-chain fatty acids. Further research is required in this area to explore the cardioprotective effect of coenzyme complex on 5-FU-induced coronary artery vasospasm.…”

Section: Proposed Management Of 5-fluorouracil-induced Cardiotoxicitymentioning

confidence: 99%

Coronary Artery Vasospasm Induced by 5-fluorouracil: Proposed Mechanisms, Existing Management Options and Future Directions

Chong

Ghosh

2019

Interv Cardiol

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Cardiovascular disease and cancer are leading contributors to the global disease burden. As a result of cancer therapy-related cardiotoxicities, cardiovascular disease results in significant morbidity and mortality in cancer survivors and patients with active cancer. There is an unmet need for management of cardio-oncology conditions, which is predicted to reach epidemic proportions, and better understanding of their pathophysiology and treatment is urgently required. The proposed mechanisms underlying cardiotoxicity induced by 5-fluorouracil (5-FU) are vascular endothelial damage followed by thrombus formation, ischaemia secondary to coronary artery vasospasm, direct toxicity on myocardium and thrombogenicity. In patients with angina and electrocardiographic evidence of myocardial ischaemia due to chemotherapy-related coronary artery vasospasm, termination of chemotherapy and administration of calcium channel blockers or nitrates can improve ischaemic symptoms. However, coronary artery vasospasm can reoccur with 5-FU re-administration with limited effectiveness of vasodilator prophylaxis observed. While pre-existing coronary artery disease may increase the ischaemic potential of 5-FU, cardiovascular risk factors do not appear to completely predict the development of cardiac complications. Pharmacogenomic studies and genetic profiling may help predict the occurrence and streamline the treatment of 5-FU-induced coronary artery vasospasm. Echocardiographic measures such as the Tei index may help detect subclinical 5-FU cardiotoxicity. Further research is required to explore the cardioprotective effect of agents such as coenzyme complex, GLP-1 analogues and degradation inhibitors on 5-FU-induced coronary artery vasospasm.

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“…Chemotherapy has commonly been used alone or combinatorially with surgical intervention or radiotherapy for a variety of cancers . The clinical outcomes of chemotherapy are considered to be closely associated with the properties of chemotherapeutic agents themselves and the administration of agents besides some other factors.…”

Section: Introductionmentioning

confidence: 99%

Effect of protein adsorption on cell uptake and blood clearance of methoxy poly(ethylene glycol)‐poly(caprolactone) nanoparticles

et al. 2015

J of Applied Polymer Sci

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The interactions between nanoparticles and cells or tissues are frequently mediated by different biomolecules adsorbed onto the surface of nanoparticles. In this study, several methoxy poly(ethylene glycol)-poly(e-caprolactone) (mPEG-PCL) copolymers with various mPEG/PCL ratios were synthesized and used to produce three types of mPEG-PCL nanoparticles. The proteinadsorption behavior of nanoparticles was assessed using fetal-bovine-serum (FBS) as a model protein. The cell uptake of nanoparticles at different nanoparticle doses as well as various culture periods was examined by measuring their endocytosis rate related to Hela cells cultured in FBS-free and FBS-contained media. The blood clearance of nanoparticles was evaluated using Kunming mice to see the differences in circulation durations of nanoparticles. Results suggest that that FBS is able to significantly regulate the cell uptake of nanoparticles in vitro, and on the other hand, the size and mPEG/PCL molar ratio of mPEG/PCL nanoparticles are closely correlated to their blood clearance.

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Coenzyme Complex Decreased Cardiotoxicity When Combined with Chemotherapy in Treating Elderly Patients with Gastrointestinal Cancer

Cited by 3 publications

References 48 publications

Cardiotoxicity of Fluoropyrimidines: Epidemiology, Mechanisms, Diagnosis, and Management

Cardiotoxicity of Fluoropyrimidines: Epidemiology, Mechanisms, Diagnosis, and Management

Coronary Artery Vasospasm Induced by 5-fluorouracil: Proposed Mechanisms, Existing Management Options and Future Directions

Effect of protein adsorption on cell uptake and blood clearance of methoxy poly(ethylene glycol)‐poly(caprolactone) nanoparticles

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