Coenzyme and Prosthetic Group Biosynthesis

Hazra, Amrita B.; Chatterjee, Abhishek; Chatterjee, Debashree; Hilmey, David G.; Sanders, Jennie M.; Hanes, Jeremiah W.; Krishnamoorthy, K.; McCulloch, K.M.; Waitner, Matthew J.; O’Leary, Seán E.; Begley, Tadhg P.; Snider, Mark J.

doi:10.1016/b978-012373944-5.00069-9

Cited by 5 publications

(3 citation statements)

References 12 publications

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“…KH 2 PO 4 and molasses have multiple positive interaction on yeast growth ( chart 4A ) which may be due to mechanisms: (1) phosphorus, potassium and carbon play important roles in metabolic pathways and cellular structures, which may reinforce each other's effect. For example, phosphate is a cofactor required by some enzymes 42 and carbon plays a role in providing ATP for reactions, so their simultaneous use may affect the better regulation of enzyme activity and metabolism, which leads to improved growth. (2) The medium pH decreases rapidly in the early stages of fermentation and in the presence of nutritional sources.…”

Section: Resultsmentioning

confidence: 99%

Production of iron enriched Saccharomyces boulardii: impact of process variables

Tafazzoli,

Ghavami,

Khosravi-Darani

2024

Sci Rep

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About half of the 1.62 billion cases of anemia are because of poor diet and iron deficiency. Currently, the use of iron-enriched yeasts can be used as the most effective and possible way to prevent and treat anemia due to the ability of biotransformation of mineral compounds into the organic form. In this research, for the first time, Saccharomyces (S.) boulardii was used for iron enrichment with the aim that the probiotic properties of yeast provide a potential iron supplement besides improving the bioavailability of iron. Also, due to its higher resistance than other Saccharomyces strains against stresses, it can protect iron against processing temperatures and stomach acidic-enzymatic conditions. So, the effect of three important variables, including concentration of iron, molasses and KH2PO4 on the growth and biotransformation of yeast was investigated by the Box-Behnken design (BBD). The best conditions occurred in 3 g/l KH2PO4, 20 g/l molasses and 12 mg/l FeSO4 with the highest biotransformation 27 mg Fe/g dry cell weight (DCW) and 6 g/l biomass weight. Such yeast can improve fermented products, provide potential supplement, and restore the lost iron of bread, which is a useful iron source, even for vegetarians-vegans and play an important role in manage with anemia. It is recommended that in future researches, attention should be paid to increasing the iron enrichment of yeast through permeabilizing the membrane and overcoming the structural barrier of the cell wall.

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Section: Resultsmentioning

confidence: 99%

Production of iron enriched Saccharomyces boulardii: impact of process variables

Tafazzoli,

Ghavami,

Khosravi-Darani

2024

Sci Rep

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“…The list of significantly changed metabolites includes pantothenate and 4-phosphopantothenate, which are precursors for biosynthesis of cofactors coenzyme A (CoA) and 4-phosphopantetheine. Another metabolite that is significantly reduced upon Qst expression is lipoate, which functions as an acyl carrier cofactor similar to CoA and 4-phosphopantetheine (Hazra et al, 2009;Spalding and Prigge, 2010). Together, these findings indicate that Qst likely affects acyltransferase metabolism.…”

Section: Untargeted Metabolomics Reveals Alterations In the Central C...mentioning

confidence: 87%

Metabolic reprogramming of Pseudomonas aeruginosa by phage-based quorum sensing modulation

et al. 2022

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“…Зависимые от них ферменты катализируют порядка 160 биохимических реакций, покрывая ~4% всех классифицированных ферментативных процессов, включая трансаминирование, декарбоксилирование, β-и γ-элиминацию и замещение [87]. Во всех случаях, пиридоксаль либо пиридоксаль-5-фосфат, являющиеся с химической точки зрения альдегидами, ковалентно связываются с аминогруппой лизина апофермента, образуя основание Шиффа [88,89] и наделяя фермент биологической функциональностью. Известно, что экзотоксины и лекарственные препараты, со-Изв.…”

Section: Ho дмсоunclassified

Thermodynamics of Intermolecular Interaction Reactions of Biomolecules in Water and Water-Organic Solvents

2023

Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol.

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The paper summarizes the results of our own research into the formation of molecular complexes of cyclodextrins with biologically active polyphenol compounds in water-organic solvents, chemical equilibria in the solutions of hydrazones and Schiff bases and their metal complexes in the solutions of DNA and proteins. It was found that an increase in the content of the non-aqueous component in the binary solvent leads to a decrease in the stability of molecular complexes of cyclodextrins with polyphenols and a decrease in the exothermicity of their formation reactions. It has been shown that metal complexes in an aqueous buffer solution containing also DNA or protein dissociate, and the released cation and free ligand bind to the biomolecule. For citation: Usacheva T.R., Gamov G.A., Kuranova N.N., Zavalishin M.N., Kabirov D.N., Alister D.A., Grazhdan K.V., Gushchina A.S., Isaeva V.A., Kashina O.V., Kuzmina I.A., Tukumova N.V., Sharnin V.A. Thermodynamics of intermolecular interaction reactions of biomolecules in water and water-organic solvents. ChemChemTech [Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol.]. 2023. V. 66. N 7. P. 59-75. DOI: 10.6060/ivkkt.20236607. 6842j.

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Coenzyme and Prosthetic Group Biosynthesis

Cited by 5 publications

References 12 publications

Production of iron enriched Saccharomyces boulardii: impact of process variables

Production of iron enriched Saccharomyces boulardii: impact of process variables

Metabolic reprogramming of Pseudomonas aeruginosa by phage-based quorum sensing modulation

Thermodynamics of Intermolecular Interaction Reactions of Biomolecules in Water and Water-Organic Solvents

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