Coenzyme A Restriction as a Factor Underlying Pre-Eclampsia with Polycystic Ovary Syndrome as a Risk Factor

Hodgman, Charlie; Khan, Gulafshana; Atiomo, William

doi:10.3390/ijms23052785

Cited by 7 publications

(5 citation statements)

References 55 publications

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“…Preeclampsia is a metabolic syndrome related to pregnancy ( Udenze, 2016 ; Hodgman et al, 2022 ). Hypertension and proteinuria occur after 20 weeks of pregnancy, which is the main cause of morbidity and mortality of pregnant women and perinatal infants.…”

Section: Discussionmentioning

confidence: 99%

Clinical study on the difference in intestinal microecology between patients with preeclampsia and pregnant women at different stages of pregnancy

Xie,

Zhang,

Peng

et al. 2024

Acta Biochim. Pol.

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Objective: To explore the difference in intestinal microecology between patients with preeclampsia and pregnant women at different stages of pregnancy.Methods: From January 2020 to January 2022, clinical data, including blood routine, lipid profile, and renal function indicators, were gathered from a cohort consisting of 5 cases of preeclampsia and 34 cases of non-preeclampsia. The non-preeclampsia group was further categorized into 6 cases in the First trimester, 13 cases in the Second trimester, and 15 cases in the Third trimester. The data collection took place at the Obstetrics Department of the Maternal and Child Health Hospital of Hubei Province. Additionally, fecal samples were obtained from each subject for 16S rDNA gene sequencing and subsequent analysis. The clinical data and composition characteristics of the gut microbiota in each group were analyzed, and the correlation between gut microbiota and clinical data was analyzed by the Spearman correlation analysis method.Results: In comparison to pregnant women without preeclampsia, preeclampsia patients exhibited a statistically significant elevation in blood routine parameters (WBC, N, L, and PLT count), a rise in lipid-related indicators (TC, TG, and LDL-C levels), a reduction in HDL-C levels, and an increase in renal function-related indicators (Cr, BUN, UA and Pro levels). Compared with non-preeclampsia pregnant women, preeclampsia women exhibited an augmented diversity of gut microbiota. Differences in gut microbiota composition between the two groups were observed at the gate and genus levels. Moreover, there are significant differences in the composition of gut microbiota between the preeclampsia group and the third-trimester group in terms of genus and species, and this difference is mainly caused by Prevotella and s_ Bacteroides_ Uniformis and Ruminococcus_ bromii. In addition, actinobacteria, bifidobacterium at the genus level, and Ruminococcus_bromii at the species level are positively correlated with clinically relevant indicators (excluding HDL-C).Conclusion: There are significant differences in gut microbiota between preeclampsia pregnant women and late pregnancy pregnant without preeclampsia, including Prevotella and Bacteroides_ Uniformis, and Ruminococcus_ bromii. In addition, these differential bacteria are correlated with most clinical indicators. However, additional comprehensive analysis is required to ascertain the functional correlation between these bacteria and clinical indicators.

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Section: Discussionmentioning

confidence: 99%

Clinical study on the difference in intestinal microecology between patients with preeclampsia and pregnant women at different stages of pregnancy

Xie,

Zhang,

Peng

et al. 2024

Acta Biochim. Pol.

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“…This may lead to diminished levels of CoA derivatives in the placenta, thereby inducing mitochondrial stress, inflammation, and pre-eclampsia. [66] Additionally, diminished FABP (fatty acid binding protein), PPARɤ and its functional unit RXRɑ expressions were all observed in the PCOS placenta. FABPs bind fatty acids in the cytoplasm and transport them to their final destinations, including to the nuclear receptors, PPAR and RXR.…”

Section: Discussionmentioning

confidence: 99%

Dissecting the Impact of Maternal Androgen Exposure on Offspring Health through Targeting the Androgen Receptor in Developmental Programming

Lu,

Jiang,

et al. 2023

Preprint

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Women with polycystic ovary syndrome (PCOS) exhibit sustained elevation in circulating androgens during pregnancy, an independent risk factor linked to pregnancy complications and adverse neonatal outcomes. Yet, further investigation is required to understand the precise mechanisms and the impact on cell-type specific placental dysfunction. To explore these dynamics, a PCOS-like mice model was induced with continuous androgen exposure throughout pregnancy, mimicking the human-PCOS. This resulted in impaired placental and embryonic development, leading to mid-gestation lethality. Co-treatment with the androgen receptor blocker, flutamide, prevented this lethality. Comprehensive analysis using whole-genome bisulfite and RNA sequencing revealed the diminished proportion of trophoblast precursors by downregulation ofCdx2. The absence ofGcm1,Synb,andPrl3b1further resulted in decreased numbers of syncytiotrophoblasts and sinusoidal trophoblast giant cells, leading to observed compromised placenta labyrinth formation. Importantly, human trophoblast organoids exposed to androgens exhibited analogous alterations, highlighting impaired trophoblast differentiation as a key feature in PCOS-related pregnancy complications. Remarkably, all effects were mediated through the androgen receptor pathways, as demonstrated by comparable offspring phenotypes to controls when treated with flutamide. These findings provide novel insight into the PCOS-related pregnancy complications, and potential cellular targets for future treatment.

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“…Again, more clinical studies are needed to decipher the interaction between MetS, PCOS, and preeclampsia. [27][28][29][30]…”

Section: Preeclampsiamentioning

confidence: 99%

Relationship between Polycystic Ovary Syndrome and Metabolic Syndrome

Cerón

2023

TJOR

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Polycystic ovary syndrome (PCOS) is a heterogeneous, complex, and widely misunderstood endocrine disorder that affects intermediate metabolism, the cardiovascular and reproductive systems, and has social and psychological consequences. The prevalence and incidence of PCOS is high among women with Metabolic Syndrome (MetS). In Mexico, the hyperandrogenic subtype is the most prevalent of the characterized subtypes and is characterized by hyperandrogenism, insulin resistance, and ovulatory dysfunction. Central obesity plays a role in the development of the hyperandrogenic subtype as adipositopathy can cause a syndrome of insulin resistance and androgen excess, both of which contribute to cardiovascular comorbidities. These two syndromes share similar pathophysiological mechanisms, suggesting that PCOS could be a complication of MetS or vice versa. The purpose of this article is to explore the relationship between MetS and PCOS, with a focus on pathogenesis, infertility, microbiota, comorbidities, and treatment.

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Coenzyme A Restriction as a Factor Underlying Pre-Eclampsia with Polycystic Ovary Syndrome as a Risk Factor

Cited by 7 publications

References 55 publications

Clinical study on the difference in intestinal microecology between patients with preeclampsia and pregnant women at different stages of pregnancy

Clinical study on the difference in intestinal microecology between patients with preeclampsia and pregnant women at different stages of pregnancy

Dissecting the Impact of Maternal Androgen Exposure on Offspring Health through Targeting the Androgen Receptor in Developmental Programming

Relationship between Polycystic Ovary Syndrome and Metabolic Syndrome

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