Cœliac Infertility: An Indication for Dietary Gluten Restriction?

Morris, Jenny; Adjukiewicz, A.B.; Read, A. E.

doi:10.1016/s0140-6736(70)90572-6

Cited by 59 publications

(34 citation statements)

References 13 publications

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“…In 1970, Morris et al reported three celiac patients with infertility, who were able to give birth after dietary gluten restriction [1], establishing the possible relationship between these two entities, and the potential beneficial role of gluten free diet (GFD). On the contrary, Jackson et al described a cohort of women suffering from infertility that were tested for CD by means of serology [7].…”

Section: Female Infertility In Celiac Diseasementioning

confidence: 99%

“…This genetic susceptibility to develop CD has been attributed to the presence of HLA DQ2 and DQ8 haplotypes, which are necessary but not sufficient for the development of the disease, since HLA DQ2 is carried by approximately a third of the general population [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…Among atypical presentations of CD, both female and male infertility problems and adverse pregnancy outcomes have been described [1,2]. Infertility is defined as the impossibility of conceiving after 12 months of unprotected intercourse [5].…”

Section: Introductionmentioning

confidence: 99%

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Celiac Disease and the Risk of Infertility

Olivera¹,

Lasa²

2016

IJCD

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Celiac Disease is a chronic inflammatory disease, caused by an abnormal immune response triggered by intestinal exposure to dietary gluten, the protein fraction of wheat, rye and barley, in genetically susceptible individuals. Among atypical presentations of Celiac Disease, reproductive disorders and adverse pregnancy outcomes have been reported. Infertility is defined as the impossibility of conceiving after 12 months of unprotected intercourse. It can be related to both male and female factors, with the latter subdivided into ovarian, tubal, endometrial or unexplained causes. Celiac Disease has been related to infertility, but the evidence is inconclusive. In this review, we discuss the effect of Celiac Disease in both male and female fertility, as well as the possible mechanisms that may be involved.

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Section: Female Infertility In Celiac Diseasementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Celiac Disease and the Risk of Infertility

Olivera¹,

Lasa²

2016

IJCD

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“…Infertility may be the first clinical symptom of subclinical celiac disease. In the early 1970s, Morris et al [5] described 3 patients in whom active celiac disease was associated with infertility which abated when the disease was controlled with dietary gluten restriction. None of these patients were malnourished or severely anemic, all had normal serum B 12 levels and only 1 had low serum folate levels.…”

Section: Femalementioning

confidence: 99%

“…The occurrence of subfecundity is well recognized in association with celiac disease [5,7,[9][10][11]. The effects of untreated celiac disease on conception, recurrent miscarriage, fetal growth restriction, birth weight and perinatal outcome has been addressed by case reports [19][20][21] and cohort-or case-controlled studies.…”

Section: Pregnancymentioning

confidence: 99%

Celiac Disease: Fertility and Pregnancy

Eliakim

Sherer

2001

Gynecol Obstet Invest

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Celiac disease (gluten-sensitive enteropathy) may manifest clinically with an array of nongastrointestinal symptoms among which are: dermatitis herpetiformis; dementia; depression; various neurological symptoms; osteoporosis; osteomalacia; dental enamel defects, and anemia of various types. Important data have accumulated in recent years regarding the association between celiac disease, fertility and pregnancy. Many primary care obstetricians and gynecologists and perinatologists are not aware of these important relationships. The aim of this review, utilizing a MEDLINE search from 1966 through March 2000 of the English language, is to describe the possible effects of celiac disease and its treatment upon the reproductive cycle, fertility, pregnancy, and menopause. Review of the literature reveals that patients with untreated celiac disease sustain a significantly delayed menarche, earlier menopause, and an increased prevalence of secondary amenorrhea. Patients with untreated celiac disease incur higher miscarriage rates, increased fetal growth restriction, and lower birth weights. It appears that improvement of celiac disease, as reflected by restoration of small bowel mucosa associated with implementation of a gluten-free diet, may decrease miscarriage rates, improve fetal nutritional support and overall perinatal outcome.

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Disorders of the Gastrointestinal Tract

Fagan¹

2002

Medical Disorders in Obstetric Practice

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Cœliac Infertility: An Indication for Dietary Gluten Restriction?

Cited by 59 publications

References 13 publications

Celiac Disease and the Risk of Infertility

Celiac Disease and the Risk of Infertility

Celiac Disease: Fertility and Pregnancy

Disorders of the Gastrointestinal Tract

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