Coeliac disease is the most common cause of chronic diarrhoea in Iran

Shahbazkhani, Bijan; Mohamadnejad, Mehdi; Malekzadeh, Reza; Akbari, Mohammad Reza; Esfahani, Mandana; Nasseri‐Moghaddam, Siavosh; Sotoudeh, Masoud; Elahyfar, Amin

doi:10.1097/01.meg.0000108327.52416.c3

Cited by 17 publications

(9 citation statements)

References 15 publications

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“…In Iran, Lebanon, Iraq, Saudi Arabia and Kuwait, CD has been reported to be one of the most common causes of chronic diarrhea. [14][15][16] This is almost similar to our findings. The second common symptom was weight loss (14%).…”

Section: Discussionsupporting

confidence: 91%

Celiac disease in the Red Sea state of Sudan

Ageep

2012

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Section: Discussionsupporting

confidence: 91%

Celiac disease in the Red Sea state of Sudan

Ageep

2012

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“…[12] In other studies from northern Iran, a high prevalence of CD was noticed in high-risk groups such as patients with chronic diarrhea and diabetes mellitus. [1920] Although the reported series stated that the prevalence of CD was high in our country, few cases of CD were seen in our daily clinical practice, in spite of using newly developed serological tests such as anti-tTG that are available in most laboratories. Despite the application of simple serological tests in diagnosis of CD, there are few studies from Middle East countries addressing the prevalence of this disease in populations such as those in Syria and Israel.…”

Section: Discussionmentioning

confidence: 97%

Prevalence of celiac disease in Shiraz, southern Iran

Saberi-Firouzi

Omrani

Nejabat

et al. 2008

Saudi J Gastroenterol

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Background/AimThis study was performed to evaluate the prevalence of celiac disease (CD) in Shiraz, southern Iran.Materials and MethodsSerum samples were collected from 1440 persons (age range = 20-83 years, mean age = 45.4 years) in 2004 and screened for endomysial and tissue transglutaminase antibodies. A questionnaire was completed for all subjects in relation to gastrointestinal (GI) symptoms and cases with positive serology were requested to undergo small-bowel biopsy.ResultsSeven cases (0.5%) were positive for IgA anti-tissue transglutaminase (anti-tTG), and only two (0.14%) were positive for IgA anti-endomysial antibody (anti-EMA), both of whom had highly positive anti-tTg levels (40.4 and 48.0 IU/l). The major clinical symptoms of CD, such as recurrent abdominal pain and change in bowel habits were present in all patients with positive anti-tTG assays. Only five subjects with positive serology agreed to undergo upper GI endoscopy and duodenal biopsy. Three of these cases were reported with Marsh I histologic findings, while in the two cases with positive serologic anti-EMA, more advanced forms of CD were present.ConclusionThe prevalence of CD in apparently healthy adults was lower than the reported series from northern parts of the country; therefore, we suggest a more long-term follow-up study in high-risk groups, especially in the apparently healthy subjects in our region.

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“…We found that CD is present in about 9.2% of the patients coming with typical symptoms (12.1% (13/107) of the patients with chronic diarrhea) and 4.0% of those who come with atypical symptoms of malabsorption. Other studies from Iran also reported that CD is the most common cause of chronic nonbloody diarrhea in adults and children, ranging from 6.5% to 19% [15, 16]. These results indicate that classic presentation of malabsorption, specially with chronic diarrhea, is the main presentation of CD in our society.…”

Section: Discussionmentioning

confidence: 64%

Frequency of Celiac Disease in Adult Patients with Typical or Atypical Malabsorption Symptoms in Isfahan, Iran

Kouhestani

Karimi²,

Baghaei³

et al. 2012

Gastroenterology Research and Practice

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Aim. Atypical presentations of celiac disease (CD) have now been shown to be much more common than classical (typical) form. We evaluated the frequency of CD among adult patients with typical or atypical symptoms of CD. Materials and Methods. Patients referred to two outpatient gastroenterology clinics in Isfahan (IRAN) were categorized into those with typical or atypical symptoms of CD. IgA antitissue transglutaminase antibody was assessed and followed by duodenal biopsy. In patients for whom endoscopy was indicated (independent of the serology), duodenal biopsy was taken. Histopathological changes were assessed according to the Marsh classification. Results. During the study period, 151 and 173 patients with typical and atypical symptoms were evaluated (mean age = 32.8 ± 12.6 and 35.8 ± 14.8 years, 47.0% and 56.0% female, resp.). Frequency of CD in patients with typical and atypical symptoms was calculated, respectively, as 5.9% (9/151) and 1.25% (3/173) based on positive serology and pathology. The overall frequency was estimated as at least 9.2% (14/151) and 4.0% (7/173) when data of seronegative patients were also considered. Conclusions. CD is more frequent among patients with typical symptoms of malabsorption and these patients should undergo duodenal biopsy, irrespective of the serology. In patients with atypical symptoms, serological tests should be performed followed by endoscopic biopsy, and routine duodenal biopsy is recommended when endoscopic evaluation is indicated because of symptoms.

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Coeliac disease is the most common cause of chronic diarrhoea in Iran

Abstract: CD is the most common cause of adult chronic non-bloody diarrhoea in Tehran.

Cited by 17 publications

References 15 publications

Celiac disease in the Red Sea state of Sudan

Celiac disease in the Red Sea state of Sudan

Prevalence of celiac disease in Shiraz, southern Iran

Frequency of Celiac Disease in Adult Patients with Typical or Atypical Malabsorption Symptoms in Isfahan, Iran

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