Coeliac Disease, Fertility, and Pregnancy

Ferguson, Roger K.; Holmes, G. K. T.; Cooke, W. T.

doi:10.3109/00365528209181045

Cited by 92 publications

(75 citation statements)

References 11 publications

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“…In females, there is a trend to late menarche, amenorrhea, early menopause and infertility, which respond positively to gluten withdrawal. 47 Moreover, there is also a greater frequency of recurrent miscarriages (mainly in the first 3 months of pregnancy), stillbirth and neonatal death. 48 In males, impotence, decreased sexual activity, infertility, abnormalities of sperm morphology and motility may be expressions of CD.…”

Section: Introductionmentioning

confidence: 99%

Celiac disease: diagnostic criteria in progress

2011

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Until a few years ago, celiac disease (CD) was thought to be a rare food intolerance that was confined to childhood and characterized by severe malabsorption and flat intestinal mucosa. Currently, CD is regarded as an autoimmune disorder that is common in the general population (affecting 1 in 100 individuals), with possible onset at any age and with many possible presentations. The identification of CD is challenging because it can begin not only with diarrhea and weight loss but also with atypical gastrointestinal (constipation and recurrent abdominal pain) and extra-intestinal symptoms (anemia, raised transaminases, osteoporosis, recurrent miscarriages, aphthous stomatitis and associated autoimmune disorders), or it could be completely symptomless. Over the last 20 years, the diagnostic accuracy of serology for CD has progressively increased with the development of highly reliable tests, such as the detection of IgA tissue transglutaminase and antiendomysial and IgG antideamidated gliadin peptide antibodies. The routine use of antibody markers has allowed researchers to discover a very high number of 'borderline' cases, characterized by positive serology and mild intestinal lesions or normal small intestine architecture, which can be classified as potential CD. Therefore, it is evident that the 'old celiac disease' with flat mucosa is only a part of the spectrum of CD. It is possible that serology could identify CD in its early stages, before the appearance of severe intestinal damage. In cases with a positive serology but with mild or absent intestinal lesions, the detection of HLA-DQ2 and HLA-DQ8 can help reinforce or exclude the diagnosis of gluten sensitivity.

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Section: Introductionmentioning

confidence: 99%

Celiac disease: diagnostic criteria in progress

2011

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“…In 74 celiac patients from the United Kingdom [3], the reproductive period was longer for those on a GFD compared to those not on a diet but maternal health was not seriously impaired. A lower incidence of spontaneous abortions in celiacs on a GFD was also recorded.…”

Section: Discussionmentioning

confidence: 99%

Evolution of Reproductive Disorders Related to Celiac Disease under Gluten-free Diet

Ayoub¹,

Firwana²,

Amjahdi³

et al. 2017

IJCD

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Introduction: Celiac disease (CD) is an autoimmune enteropathy induced by the ingestion of gluten (wheat, barley, rye). The classical form has become a minority. Currently, the most frequent forms of presentation are extradigestive with various manifestations, among others, reproductive disorders. The aim of our study is to assess the frequency of these disorders in CD and their evolution under gluten-free diet (GFD). Materials and methods: Descriptive retrospective study of 173 patients with CD followed in the department of diseases of the digestive tract "Médecine C" of the Ibn Sina Hospital in Rabat, over a period of 18 years. Result: In 173 patients with CD, 58 patients (28,9%) had reproductive disorders. There are 53 women and 5 men. The average age was 32,25 years. The diagnosis of CD is based on histology and serology. The Reproductive problems were never isolated but always associated with other digestive or extra-digestive signs at the time of diagnosis of CD. These disorders are represented by: delayed puberty in 11 patients (19%), secondary amenorrhea in 13 patients (22.4%), irregular menstrual in 12 patients (20.6%), absence of development of secondary sex characteristics in 8 patients (12.5%), spontaneous abortions in 7 patients (10.9%), menometrorrhagia in 4 patients (13.8%), primary sterility in 5 patients (8.6%), early menopause in 6 patients (10.3%), premature delivery in 3 patients (5%), primary amenorrhea in 2 patients (3.4%) and intrauterine fetal death in one case (1.7%). All our patients have had a GFD. 15 patients lost to follow-up, two patients died and 12 patients undergoing follow-up. The remaining 29 patients, the evolution of reproductive disorders under GFD was favorable in 26 patients (90%), with the normalization of cycles in 15 patients, resumption of cycles in 6 patients, development of secondary sex characteristics in 2 patients, fertility resumption in one case, initiation of cycles after primary amenorrhea in one case and delivery of a newborn at term after premature deliveries in one case. The evolution was unfavorable in 3 patients with the notion of miscarriage 4 years after the start of the GFD in one patient and the absence of cycle resumption in two patients. Conclusion: The reproductive disorders associated with CD are frequent and varied. In our study, these disorders responded very well under a GFD, conducted in 90% of patients. These disorders are thus reversible under this diet.

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“…In 74 celiac patients from the United Kingdom [2], the regenerative period was longer for those on a sans gluten eat less contrasted with those not on an eating regimen but rather maternal well-being was not truly disabled. A lower frequency of unconstrained premature births in celiacs on a sans gluten eating routine was additionally recorded.…”

Section: Discussionmentioning

confidence: 99%

“…These progressions were clearly revised with a sans gluten eat less carbs [11]. Higher rates of either unnatural birth cycles or unconstrained premature births were likewise recorded from different focuses situated in various nations including Argentina, Italy and the United Kingdom [2,3,6,12].…”

Section: Altered Female Fertilitymentioning

confidence: 99%

Evolution of Reproductive Disorders Related to Celiac Disease Under Glutenfree Diet

Aomari¹,

Firwana²,

Amjahdi³

et al. 2017

J Gastrointest Dig Syst

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Introduction: Celiac disease is an autoimmune enteropathy induced by the ingestion of gluten (wheat, barley, rye). The classical form has become a minority. Currently, the most frequent forms of presentation are extraintestinal with various manifestations, among others, reproductive disorders. The aim of our study is to assess the frequency of these disorders in celiac disease and their evolution under gluten-free diet.

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Coeliac Disease, Fertility, and Pregnancy

Cited by 92 publications

References 11 publications

Celiac disease: diagnostic criteria in progress

Celiac disease: diagnostic criteria in progress

Evolution of Reproductive Disorders Related to Celiac Disease under Gluten-free Diet

Evolution of Reproductive Disorders Related to Celiac Disease Under Glutenfree Diet

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