Coeliac disease associated with psoriasis

Birkenfeld, Shlomo; Dreiher, Jacob; Weitzman, Dahlia; Cohen, Arnon D

doi:10.1111/j.1365-2133.2009.09398.x

Cited by 91 publications

(82 citation statements)

References 24 publications

(27 reference statements)

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“…anti-gliadin antibodies, AGAs) and the setting, including the design as single-centre studies performed in tertiary centres [8,9,10,11,12,13,14,20]. …”

Section: Discussionmentioning

confidence: 99%

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Association between Coeliac Disease and Psoriasis: Italian Primary Care Multicentre Study

Bastiani¹,

Gabrielli

Lora³

et al. 2015

Dermatology

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Background: Studies assessing the association between coeliac disease (CD) and psoriasis show conflicting results. Objective: To assess in the primary care setting the prevalence of CD in patients with psoriasis and the response to a gluten-free diet (GFD) in subjects with psoriasis and CD. Methods: We enrolled 218 patients with psoriasis and 264 controls. Coeliac screening was carried out in all subjects (Eurospital, Trieste, Italy). In subjects with a positive serology, the diagnosis of CD was confirmed histologically. Results: Nine (4.1%) psoriatic patients had positive anti-tissue transglutaminase antibodies compared to only 1 among controls (0.4%, p < 0.05; OR 2.03, 95% CI 1.42-90.11). The diagnosis of CD was confirmed histologically in all 10 subjects. At 6 months GFD was associated with a great improvement of skin lesions in 7 out of 8 patients with psoriasis. Conclusion: Our multicentre primary care study showed an high prevalence of CD in psoriasis and an improvement of skin lesions in CD under GFD.

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“…anti-gliadin antibodies, AGAs) and the setting, including the design as single-centre studies performed in tertiary centres [8,9,10,11,12,13,14,20]. …”

Section: Discussionmentioning

confidence: 99%

“…Several studies investigating the possible association between CD and psoriasis were subsequently published. However, due to contrasting data the available results are inconclusive [8,9,10,11,12,13,14]. Most of the few available data on the effects of GFD on psoriatic skin lesions are contained in case reports [14,15,16,17].…”

Section: Introductionmentioning

confidence: 99%

Association between Coeliac Disease and Psoriasis: Italian Primary Care Multicentre Study

Bastiani¹,

Gabrielli

Lora³

et al. 2015

Dermatology

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“…Based on the positive anti-transglutaminase antibodies which are a highly sensitive and specific marker of coeliac disease, we can confirm the association between coeliac disease and psoriasis. In other words, this result shows a higher prevalence of coeliac disease in patients with psoriasis than in the general population 1,2,4 . For this reason, dermatologists and general practitioners are advised to ask their psoriatic patients questions concerning bowel problems, and to perform tests for coeliac disease via thorough examination 2 .…”

Section: Discussionmentioning

confidence: 63%

“…In other words, this result shows a higher prevalence of coeliac disease in patients with psoriasis than in the general population 1,2,4 . For this reason, dermatologists and general practitioners are advised to ask their psoriatic patients questions concerning bowel problems, and to perform tests for coeliac disease via thorough examination 2 . The early diagnosis of coeliac disease by detecting specific antibodies can prevent complications that can occur in untreated disease.…”

Section: Discussionmentioning

confidence: 63%

“…The consequence of the reaction to gluten is damaged mucosa of the small intestine (mostly involving duodenum and jejunum) with varying degrees of atrophy and inflammatory changes 1 . The results of some recent studies show an increased occurrence of psoriasis in patients with coeliac disease 1,2 . The association between coeliac disease and psoriasis is strongly suggested as a gluten-free diet leads to a clear improvement and disappearance of psoriatic skin lesions in some patients 3,4 .…”

Section: Introductionmentioning

confidence: 99%

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Gastrointestinal comorbidities in patients with psoriasis in the Czech Republic: The results of 189 patients with psoriasis and 378 controls

Jůzlová¹,

Votrubová²,

Džambová³

et al. 2016

BIOMED PAP

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Aims. The aim of the study was to investigate gastrointestinal comorbidities, identify risk factors and detect the early stages of autoimmune gastrointestinal diseases, such as Crohn's disease, ulcerative colitis and coeliac disease in patients with psoriasis. Methods. This was a hospital-based case-control study. Patients with chronic plaque psoriasis were included as cases. The control group consisted of patients with other skin diseases and who complied with the same selection criteria as cases. Two controls were selected per one case. We analysed the following antibodies (ASCA, AEP, p-ANCA, AGC, EMA, ARA, tTG, AGA) and non-specific signs of gastrointestinal diseases. Results. There were significant differences between cases and controls in several parameters. Leucocyte count, CRP, total protein, transglutaminase IgA antibodies and p-ANCA were statistically significant between groups (P < 0.05). In the binary logistic model, leucocyte count and p-ANCA (for all parameters included in the logistic model P ≤ 0.001) were associated with psoriasis. Conclusion. Patients with psoriasis should be regularly screened for coeliac and inflammatory bowel disease. Early diagnosis of gastrointestinal diseases and risk factors may prevent complications and greatly improve the patient's quality of life.

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Coexistent Solid Malignancies in Pemphigus

et al. 2018

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The association of pemphigus vulgaris and pemphigus foliaceus with comorbid malignancies is yet to be firmly established. OBJECTIVE To estimate the association between pemphigus and a wide range of nonhematologic malignancies using one of the largest cohorts of patients with pemphigus to date. DESIGN, SETTING, AND PARTICIPANTS For this cross-sectional study, we used the computerized database of Clalit Health Services, the largest public health care provider organization in Israel insuring 4.4 million individuals in the settings of general community clinics, primary care and referral centers, and ambulatory and hospitalized health care. The study included 1985 patients with pemphigus and 9874 control patients and was conducted from January 2004 to December 2014. MAIN OUTCOMES AND MEASURES The prevalence of 17 different solid malignancies was compared between patients diagnosed with pemphigus and age-, sex-, and ethnicity-matched control patients; χ 2 and t tests were used for univariate analysis, and a logistic regression model was used for multivariate analysis. The association was examined following a sensitivity analysis that included only cases treated with long-term pemphigus-specific medications (corticosteroids, immunosuppressants, or rituximab), and following the adjustment for several confounding factors. RESULTS Overall, the total sample included 11 859 eligible patients, of whom 1985 were patients with pemphigus (mean [SD] age at presentation, 72.1 [18.5] years; 1188 women [59.8%]). In patients with pemphigus compared with control patients, there was a greater prevalence of esophageal cancers (0.4% vs 0.1%; odds ratio [OR], 2.9; 95% CI, 1.1-7.4) and laryngeal cancers (0.6% vs 0.3%; OR, 2.0; 95% CI, 1.0-4.1). No significant associations between pemphigus and other solid malignancies were observed. Estimates were not altered significantly after controlling for comorbidities, health care overutilization, immunosuppressive therapy, and other malignancy-specific risk factors (ie, smoking and alcohol abuse in laryngeal cancer, gastroesophageal reflux disease in esophageal cancer). CONCLUSIONS AND RELEVANCE Significant associations were observed between pemphigus and solid malignancies of the larynx and the esophagus. Physicians treating patients with pemphigus should be aware of these findings. Further observational studies are warranted to establish this association in other cohorts.

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Coeliac disease associated with psoriasis

Abstract: Patients with psoriasis have a greater prevalence of CD than matched controls. Recent studies showed a possibility of undiagnosed CD among patients with psoriasis. Therefore, physicians treating patients with psoriasis should be aware of this possible association.

Cited by 91 publications

References 24 publications

Association between Coeliac Disease and Psoriasis: Italian Primary Care Multicentre Study

Association between Coeliac Disease and Psoriasis: Italian Primary Care Multicentre Study

Gastrointestinal comorbidities in patients with psoriasis in the Czech Republic: The results of 189 patients with psoriasis and 378 controls

Coexistent Solid Malignancies in Pemphigus

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