Coeliac disease and rheumatoid arthritis

Parke, Anne; Fagan, Elizabeth A.; Chadwick, V. S.; Hughes, G. R. V.

doi:10.1136/ard.43.3.378

Cited by 33 publications

(13 citation statements)

References 21 publications

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“…Nonspecific mono-or polyarthritis have been described in many case reports as occurring in connection Celiac disease has been reported to occur concomitantly with many other disorders. Given the high prevawith celiac disease [50][51][52][53]. In some but not all cases the joint symptoms have been alleviated on a gluten-free diet.…”

Section: Non-intestinal Symptoms and Complicationsmentioning

confidence: 99%

Clinical Features of Celiac Disease Today

Collin

Kaukinen

Mäki³

1999

Dig Dis

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The clinical spectrum of celiac disease has widened over the past decades. The condition is no longer a severe malabsorption syndrome. Instead, a typical celiac disease patient today has merely mild abdominal symptoms. Malabsorption can be subclinical or absent, and there is usually only moderate, if any, loss of weight. Simultaneously, the current prevalence has increased from 1:1,000 to 1:300 inhabitants, or even higher. Clinically silent celiac disease cases are being detected in increasing numbers since the introduction and widespread use of serologic screening tests. Symptoms of celiac disease can appear outside the intestine, a typical example being dermatitis herpetiformis. Gluten intolerance is no longer limited to overt villous atrophy. Inflammation without villous damage may be observed in genetically susceptible individuals. The term latent celiac disease is applied in situations where the patient has normal villous architecture while on a gluten-containing diet, but later develops small bowel villous atrophy compatible with celiac disease.

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Section: Non-intestinal Symptoms and Complicationsmentioning

confidence: 99%

Clinical Features of Celiac Disease Today

Collin

Kaukinen

Mäki³

1999

Dig Dis

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“…The relationships between DH, celiac disease, and rheumatoid arthritis have drawn attention in the recent years [2,[4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Celiac disease of the joint

2010

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A 42-year-old woman presented with a 3-week history of left knee pain and swelling. She had suffered dermatitis herpetiformis for 12 years, proved by skin biopsy. She had never been on gluten-free diet. Knee pain increased with motion and her gait was antalgic. On admission, she was mainly dependent on wheelchair due to pain and limitation. Treatment plan consisted of gluten-free diet, stretching and strengthening exercises, analgesic or nonsteroidal anti-inflammatory drugs when needed. She responded well to gluten-free diet. Association of joint involvement and dermatitis herpetiformis is more than just coincidental. Possible immunopathogenesis and role of gluten-free diet on arthritis treatment are discussed.

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“…158], In 1984. Parke et al [ 159] reported 3 patients with coexistent erosive seropositive rheumatoid arthritis and celiac disease. All 3 patients experienced sig nificant improvement of their arthritis after treatment with gluten-free diet.…”

Section: The Articular Manifestations Of Gluten-sensitive Enteropathymentioning

confidence: 99%

Joint Manifestations in Gastrointestinal Diseases

Gran

Husby²

1992

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This review addresses the clinical picture of rheumatic diseases seen in Whipple’s disease, gluten-sensitive enteropathy, pseudomembranous colitis, collagenous colitis and that developing after enteric infections and intestinal bypass operations for morbid obesity. These disorders examplify the interplay between antigen entrance through the gastrointestinal canal, specific bacterial properties and genetic host factors such as HLA B27. In most cases such an interplay results in formation of circulating immune complexes causing the development of peripheral joint disease.

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Coeliac disease and rheumatoid arthritis

Cited by 33 publications

References 21 publications

Clinical Features of Celiac Disease Today

Clinical Features of Celiac Disease Today

Celiac disease of the joint

Joint Manifestations in Gastrointestinal Diseases

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