Salinization and alkalization of land resources are the major obstacles to their optimal usage in many arid and semi-arid regions of the world, including Iran, since potential evapotranspiration is more noteworthy than precipitation in these areas. The amount of water that enters the soil is low and this results in salt accumulation in soils, which makes the soil infertile. Moreover, existence of salts, for example, sodium, in soils causes dispersion of soil particles and soil degradation, and intensifies soil erosion too. Monitoring exchangeable sodium percentage (ESP) variability in soils is both time-consuming and costly. However, in order to estimate the amounts of amendments and land management, it is necessary to know ESP variation and values in sodic or saline and sodic soils. Thus, introducing a method, which utilizes easily obtained indices to estimate ESP indirectly is more optimized and economical. Input and output data, i.e., EC e (dS m-1), clay (%), pH and ESP (%) were collected and measured from 100 soil samples in light of a stratified random sampling from Mashhad Plain, Khorasan-e-Razavi Province, Northeast Iran. This study aims to propose some models to estimate ESP by easily obtained properties of soil. In this regard, the efficiency of artificial intelligence-based (AI) models (i.e., Artificial Neural Network, ANN, and Adaptive Neuro-Fuzzy Inference System, ANFIS) was investigated and compared. Accuracy results showed that owing to highest R 2 and the lowest mean square error (MSE), ANFIS model predictions were superior to the MLP model for indirect estimation of soil exchangeable sodium percentage.