Abstract:Diabetic kidney disease (DKD) is the most serious microvascular complication during the development of diabetes with the characterizations of glomerular basement membrane thickening, mesangial expansion, and glomerular sclerosis, eventually leading to end-stage renal disease. This study aimed to investigate the melioration effect of Codonopisis tangshen Oliv. (COD) on the DKD model, which was established by unilateral nephrectomy (UN)-high fat diet feeding (HFD) combined with streptozotocin (STZ). After the DK… Show more
“…29 The CPN extract has also been reported to have the therapeutic effect on diabetic kidney. 30 In addition, four compounds isolated from CPN have been proved to have yeast α-glucosidase inhibitory activity in vitro . However, there has not been any study to comprehensively evaluate the hypoglycemic effects of CPN in vitro and in vivo by inhibiting α-glucosidase and confirm the chemical ingredients of active site of CPN by using UHPLC-Triple-TOF-MS/MS.…”
Codonopsis pilosula (Franch.) Nannf. (CPN), mainly planted in the northwest region, is a traditional Chinese medicine/good health food for nourishing qi and promoting blood circulation. This study firstly evaluated the...
“…29 The CPN extract has also been reported to have the therapeutic effect on diabetic kidney. 30 In addition, four compounds isolated from CPN have been proved to have yeast α-glucosidase inhibitory activity in vitro . However, there has not been any study to comprehensively evaluate the hypoglycemic effects of CPN in vitro and in vivo by inhibiting α-glucosidase and confirm the chemical ingredients of active site of CPN by using UHPLC-Triple-TOF-MS/MS.…”
Codonopsis pilosula (Franch.) Nannf. (CPN), mainly planted in the northwest region, is a traditional Chinese medicine/good health food for nourishing qi and promoting blood circulation. This study firstly evaluated the...
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