Codon-usage optimization in the prokaryotic tree of life: How synonymous codons are differentially selected in sequence domains with different expression levels and degrees of conservation
Abstract:1 Prokaryote genomes exhibit a wide range of GC contents and codon usages, both 2 resulting from an interaction between mutational bias and natural selection. In order to 3 investigate the basis underlying specific codon changes, we performed a comprehensive 4 analysis of 29-different prokaryote families. The analysis of core-gene sets with 5 increasing ancestries in each family lineage revealed that the codon usages became 6 progressively more adapted to the tRNA pools. While, as previously reported, highly-7… Show more
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