Codon usage divergence of important functional genes in Mycobacterium tuberculosis

Li, Gun; Zhang, Liang; Xue, Pei

doi:10.1016/j.ijbiomac.2022.04.112

Cited by 4 publications

(1 citation statement)

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“…Whilst translational fidelity is essential for life, errors that increase phenotypic diversity may play a role in adaptation and survival under certain stress conditions ( Ribas de Pouplana et al, 2014 ). Indeed, a recent study exploring the divergence of codon usage in functionally important genes in M. tuberculosis found that selective pressure drives codon usage, with implications for understanding evolutionary divergence, the emergence of antibiotic resistance mutations and ultimately treatment outcomes ( Li et al, 2022 ). Evaluating genome-wide translational fidelity obviously relies on gene annotation.…”

Section: Insights From Ribosome Profiling In Mycobacteriamentioning

confidence: 99%

Ribosome profiling enhances understanding of mycobacterial translation

Sawyer

Cortes²

2022

Front. Microbiol.

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A recent addition to the -omics toolkit, ribosome profiling, enables researchers to gain insight into the process and regulation of translation by mapping fragments of mRNA protected from nuclease digestion by ribosome binding. In this review, we discuss how ribosome profiling applied to mycobacteria has led to discoveries about translational regulation. Using case studies, we show that the traditional view of “canonical” translation mechanisms needs expanding to encompass features of mycobacterial translation that are more widespread than previously recognized. We also discuss the limitations of the method and potential future developments that could yield further insight into the fundamental biology of this important human pathogen.

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Section: Insights From Ribosome Profiling In Mycobacteriamentioning

confidence: 99%