Codon 54 polymorphism of the fatty acid binding protein gene and insulin resistance in the Japanese population

Ito, Kuninobu; Nakatani, Kaname; Fujii, Masashi; Katsuki, Akira; Tsuchihashi, K.; Murata, K; Goto, Hiroyuki; Yano, Yutaka; Gabazza, Esteban C.; Sumida, Yasuhiro; Adachi, Yukihiko

doi:10.1046/j.1464-5491.1999.00034.x

Cited by 35 publications

(21 citation statements)

References 42 publications

(43 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Its association with type 2 diabetes and insulin resistance has been confirmed in the USA and Canada, but not in Finland and Chile [32][33][34][35][36].…”

Section: Discussionmentioning

confidence: 99%

The fatty acid binding protein 2 (FABP2) polymorphism Ala54Thr and obesity in Pakistan: A population based study and a systematic meta-analysis

Shabana

Hasnain

2015

Gene

View full text Add to dashboard Cite

“…Its association with type 2 diabetes and insulin resistance has been confirmed in the USA and Canada, but not in Finland and Chile [32][33][34][35][36].…”

Section: Discussionmentioning

confidence: 99%

The fatty acid binding protein 2 (FABP2) polymorphism Ala54Thr and obesity in Pakistan: A population based study and a systematic meta-analysis

Shabana

Hasnain

2015

Gene

View full text Add to dashboard Cite

“…As shown in Figure 2C, four studies had a trend of elevated OR for the allele T (Albala et al, 2004;Takakura et al, 2005;Tavridou et al, 2009), and six studies showed a trend in the opposite direction (Lei et al, 1999;Ito et al, 1999;Carlsson et al, 2000;He, 2002;Duarte et al, 2003;Wang et al, 2011). No significant association was found between the FABP2 Ala54Thr polymorphism and obesity ( Figure 2C).…”

Section: A B Cmentioning

confidence: 94%

Association of the FABP2 Ala54Thr polymorphism with type 2 diabetes, obesity, and metabolic syndrome: a population-based case-control study and a systematic meta-analysis

Liu¹,

Wu²,

Han³

et al. 2015

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. Previous studies have reported associations between the functional FABP2 Ala54Thr (rs1799883) polymorphism and type 2 diabetes mellitus (T2DM), obesity, and metabolic syndrome in different populations with conflicting results. We investigated the association between the FABP2 Ala54Thr polymorphism and T2DM (235 cases, 431 controls), obesity (377 cases, 431 controls), and metabolic syndrome (315 cases, 323 controls) by logistic regression analysis in a Chinese study cohort recruited from Yichang, Hubei Province. We then comprehensively reviewed the association of the FABP2 Ala54Thr polymorphism with T2DM, obesity, and metabolic syndrome via meta-analysis. The strength of association was assessed by odds ratios (ORs) with 95% confidence intervals (CIs). The FABP2 Ala54Thr polymorphism was significantly associated with obesity (AT vs AA:Y. Liu et al. 1156©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (1): 1155-1168 (2015) OR = 2.633, 95%CI = 1.065-6.663, P = 0.036; TT vs AA: OR = 4.160, 95%CI = 1.609-10.757, P = 0.003) and metabolic syndrome (TT vs AA: OR = 2.273, 95%CI = 1.242-4.156, P = 0.008) by logistic regression with adjustment for covariates. However, no significant association was found between T2DM and the FABP2 Ala54Thr polymorphism. We identified 24 studies on T2DM (4517 cases, 5224 controls), 9 studies on obesity (949 cases, 2002 controls), and 6 studies on metabolic syndrome (2194 cases, 3282 controls) by literature search. The metaanalyses revealed significant associations for metabolic syndrome (T allele: OR = 1.179, 95%CI = 1.015-1.362, P = 0.031) and T2DM (T allele: OR = 1.160, 95%CI = 1.08-1.24, P < 0.001), but no association for obesity (T allele: OR = 1.069, 95%CI = 0.925-1.235, P = 0.367).

show abstract

“…54]. Ethnic differences may partly account for the disparate findings on the Ala54Thr polymorphism [55][56][57][58][59]. Two isoforms of bovine H-FABP were reported, with Asp or Asn at position 98 [60].…”

Section: Gene Structure and Regulation Of Expressionmentioning

confidence: 99%

New insights into the structure and function of fatty acid-binding proteins

Zimmerman¹,

Veerkamp²

2002

Cellular and Molecular Life Sciences (CMLS)

477

360

View full text Add to dashboard Cite

Fatty acid-binding proteins (FABPs) are members of a superfamily of lipid-binding proteins, and occur intracellularly in vertebrates and invertebrates. This review presents recent findings on the diversity of these FABPs and their proposed roles in fatty acid (FA) metabolism and other cellular processes. Special attention is paid to the structural features of the different mammalian FABP types and the physiological role of these proteins in FA transport, cell growth and differentiation, cellular signalling, gene transcription and cytoprotection. Additionally, data on FABP knockout mice and the implication of FABP in medicine are discussed.

show abstract

Codon 54 polymorphism of the fatty acid binding protein gene and insulin resistance in the Japanese population

Abstract: The allele encoding threonine in the FABP2 does not predispose to Type 2 DM or insulin resistance in the Japanese population.

Cited by 35 publications

References 42 publications

The fatty acid binding protein 2 (FABP2) polymorphism Ala54Thr and obesity in Pakistan: A population based study and a systematic meta-analysis

The fatty acid binding protein 2 (FABP2) polymorphism Ala54Thr and obesity in Pakistan: A population based study and a systematic meta-analysis

Association of the FABP2 Ala54Thr polymorphism with type 2 diabetes, obesity, and metabolic syndrome: a population-based case-control study and a systematic meta-analysis

New insights into the structure and function of fatty acid-binding proteins

Contact Info

Product

Resources

About