Coding Microsatellite Frameshift Mutations Accumulate in Atherosclerotic Carotid Artery Lesions: Evaluation of 26 Cases and Literature Review

Functional Mechanisms of Microsatellite DNA in Eukaryotic Genomes

“…Questions of growing tractability include the degree to which this causes ageing and age-related disease ( Bavarva etal. 2014 ; Kurz etal. 2015 ), and the possibility that it functions in normal brain development ( Nithianantharajah and Hannan 2007 ).…”

New Dawn for Atherosclerosis: Vascular Endothelial Cell Senescence and Death

“…Genomic instability in vascular ECs and SMCs has been recognized as a causal factor in senescence, vascular aging, and atherosclerosis [30,144,145]. Moreover, microsatellite instability and loss of heterozygosity, which is thought to be a consequence of non-productive repair of DNA breaks, has also been linked to atherosclerosis [146].…”

Immunogenomic Biomarkers and Validation in Lynch Syndrome

“…Based on the increasing knowledge of the mutational landscapes of cancers with dMMR, it can be predicted that mutant neoantigens trigger strong immune responses by CD8+ cytotoxic T cells functioning as major mediators of anti-cancer immunity [29,34]. Insertion and deletion mutations in microsatellites occur during DNA replication, and the failure to repair the mutations due to the dMMR phenotype contributes to tumorigenesis [35]. The induced shift in the protein reading frame generates neoantigens that are recognised as foreign by the immune system [34].…”