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1998
DOI: 10.1002/1529-0131(199809)41:9<1603::aid-art10>3.0.co;2-u
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Codeine and oxycodone use in patients with chronic rheumatic disease pain

Abstract: Prolonged treatment of rheumatic disease pain with codeine or oxycodone was effective in reducing pain severity and was associated with only mild toxicity. Doses were stable for prolonged periods of time, with escalations of the opioid dose almost always related to worsening of the painful condition or a complication thereof, rather than the development of tolerance to opioids. Doubts or concerns about opioid efficacy, toxicity, tolerance, and abuse or addiction should no longer be used to justify withholding … Show more

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Cited by 90 publications
(64 citation statements)
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“…They are also drugs inducing less organic toxicity as compared to anti-inflammatory drugs, and in studies using single dose of opioids there has been less cognitive impairment as compared to benzodiazepines 33 . In hospices treating patients with well-defined chronic pain, opioid abuse and addiction rates are very low 34,35 .…”
Section: Use Of Opioids In the Elderlysupporting
confidence: 80%
“…They are also drugs inducing less organic toxicity as compared to anti-inflammatory drugs, and in studies using single dose of opioids there has been less cognitive impairment as compared to benzodiazepines 33 . In hospices treating patients with well-defined chronic pain, opioid abuse and addiction rates are very low 34,35 .…”
Section: Use Of Opioids In the Elderlysupporting
confidence: 80%
“…[52] Also, administrative restrictions have generated claims of lowered access for needy patients or eroded bilateral trust. [53] In our experience and in that of others, patients with CNCP managed with opioids may be expected to develop tolerance and even physical dependence over time, but not the aberrant behaviors, including rapid dose escalation, associated with psychological addiction or drug seeking for profit [54,55,56]. No mood and/or cognitive deficits occurred post-therapy in at least one study of non-cancer pain patients, as compared to controls-in fact, medication reduced anxiety and hostility [57].…”
Section: Discussionmentioning
confidence: 99%
“…The third National Health and Nutrition Examination Survey found similar rates of analgesic medication use (8); however, these data are cross-sectional and do not allow one to accurately depict the antecedent predictors of opioid analgesic use. Several other small studies from rheumatology practices have examined opioid use in specific patient populations cared for by selected providers (9,10). These studies may not represent typical community-based prescription patterns.…”
Section: Introductionmentioning
confidence: 99%
“…Treatment for rheumatoid arthritis should be aimed at reducing inflammation with disease-modifying antirheumatic drugs, but pain control is a major goal and may not always be achieved with antirheumatic treatments. One prior survey of subjects attending a rheumatology practice at a Veterans Affairs hospital found a proportion of patients with rheumatoid arthritis taking chronic opioids similar to this study (9). However, neither prior studies nor the present study answer several important questions about opioid use in persons with rheumatoid arthritis.…”
mentioning
confidence: 99%