“…Although there is no specific treatment for RAS, topical tetracycline, chlorhexidine gluconate or other mouthwashes, topical corticosteroids or immunomodulators can be used in the clinical management of the disease. 24,30 Angular cheilitis: Inflammation begins at the corners of the lips. Over time, erosion, ulceration, fissure develops, and it is a very painful condition.…”