Çocuk ve ergenlerde Hashimoto tiroiditi: klinik ve laboratuvar bulgularının değerlendirilmesi

Dündar, Bumin Nuri; Boyaci, Aslıhan; Sangün, Özlem; Dündar, Nihal Olgaç

doi:10.4274/tpa.358.1338

Cited by 6 publications

(6 citation statements)

References 20 publications

(39 reference statements)

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“…Consistent with our study, Tuhan et al (15) found that there was no difference in terms of gender, adolescence and presence of goiter between the groups that were compared according to thyroid function status. Dündar et al (13) reported a higher rate of goiter in euthyroid cases.…”

Section: Discussionmentioning

confidence: 96%

“…Euthyroidism is the most common thyroid pattern associated with Hashimoto's thyroiditis (20-80%). Dundar et al (13) reported euthyroidism in 62.8% of children and adolescents with Hashimoto's thyroiditis, Özen et al (14) and Tuhan et al (15) reported euthyroidism in 51.2% and 36.7% of these cases, respectively.…”

Section: Discussionmentioning

confidence: 97%

“…In the literature, rates of thyroid nodules up to 34.4% have been reported in cases with Hashimoto's thyroiditis (13,15,26) . Dündar et al (13) reported thyroid nodules in 7% of children and adolescents with Hashimoto's thyroiditis and Tuhan et al (15) found thyroid nodules in 7.5% of their patients. In our study, true nodules (13 solitary, 5 multinodules) were detected in 17% of the cases.…”

Section: Discussionmentioning

confidence: 99%

“…L-thyroxine treatment is also recommended in euthyroid subjects who have large goiter leading to compression and/or tenderness (23,26) . In the literature, the rate of using L-thyroxine in cases with Hashimoto's thyroiditis varies between 40-70% (13,(26)(27)(28) . In our study, 43.5% of the cases were receiving levothyroxine treatment, while the average L-thyroxine dose to reach euthyroid state was calculated as 1.62±0.53 µg/kg/day in accordance with the literature (14) .…”

Section: Discussionmentioning

confidence: 99%

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Retrospective Analysis of Hashimoto’s Thyroiditis in Children and Adolescents: A Single Center Experience

Tunç¹,

Özkan²

2021

BUCH

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Objective: Hashimoto’s thyroiditis is an organ-specific autoimmune disease and the most common cause of goiter and acquired hypothyroidism in children and adolescents in regions devoid of endemic iodine deficiency. In this study, it was aimed to examine the epidemiological, clinical and laboratory features of Hashimoto’s thyroiditis and autoimmune diseases accompanying Hashimoto’s thyroiditis in children and adolescents. Methods: We retrospectively examined thyrotropin, free thyroxin, thyroid autoantibodies (thyroid peroxidase and thyroglobulin antibodies), immunoglobulin A (IgA), anti-tissue transglutaminase antibodies (IgA-tTG), and thyroid ultrasonography findings of 108 cases aged 5-18 years with positive anti-thyroid antibodies. Results: The female/male ratio was 80/28 and 68% of the patients were adolescents. The most common admission complaint was goiter. At the time of diagnosis, the cases had euthyroidism (44.4%), subclinical hypothyroidism (35%), overt hypothyroidism (16.6%), and hyperthyroidism (3.7%). Goiter was detected in 58 (53.7%) cases by thyroid ultrasonography. During the follow-up, overt hypothyroidism developed in 6 patients who had subclinical hypothyroidism and subclinical hypothyroidism developed in 8 patients who had euthyroidism. All patients with hyperthyroidism became euthyroid. Levothyroxine treatment was administered to 47 (43.5%) patients. Celiac disease was detected in 2 and type 1 diabetes mellitus in 1 patient. Conclusions: The prevalence of Hashimoto’s thyroiditis increases with age both in childhood and adolescence, and thyroid functions tend to deteriorate over time. Therefore, close follow-up and appropriate treatment are important. Although the prevalence of celiac disease is higher in children and adolescents with Hashimoto’s thyroiditis compared to healthy children, the true prevalence of autoimmune diseases accompanying Hashimoto’s thyroiditis will be revealed in studies to be conducted in larger patient populations.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Retrospective Analysis of Hashimoto’s Thyroiditis in Children and Adolescents: A Single Center Experience

Tunç¹,

Özkan²

2021

BUCH

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“…Hashimoto tiroiditinin sıklığı özellikle ergenlik döneminde artış göstermekte, 4 yaş altında ise oldukça nadir görülmektedir (29,30) . Bu çalışmada da Hashimoto tiroiditli hastaların %78'i pubertaldi ve ortanca yaşları literatürle uyumlu olarak 13,8 (10,(8)(9)(10)(11)(12)(13)(14)(15) yıldı.…”

Section: Discussionunclassified

The Characteristics of Children with Abnormalities Detected in Thyroid Function Tests, and Distribution of Diagnoses

Çelik¹,

Anık²

2020

BUCH

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INTRODUCTION: Thyroid function tests are among the most frequently implemented laboratory tests in primary, and secondary healthcare institutions. The aim of the present study was to investigate the demographic and clinical characteristics and final diagnosis of children referred by primary and secondary healthcare institutions with the suspicion of an abnormality in thyroid function test and/or with the initial diagnosis of specific thyroid disease. METHODS: A total of two hundred eighty-nine pediatric patients, aged between 4 and 18 years admitted to the outpatient clinics of Behçet Uz Children’s Health and Diseases Hospital between January 2018 and January 2020, were included in the study. The patient data were obtained retrospectively from the hospital records. RESULTS: A total of 66% of the patients who were included in the study were female with a median age of 12 years (8.7-14.4), while 64% of them were pubertal; and 78% of the cases were referred by secondary healthcare institutions. The most common reason for referral was isolated elevation of thyroid stimulating hormone (TSH). A total of 56% of the patients were asymptomatic at the time of admission, and thyroid function test results of 75% of them were within normal limits. When evaluated according to their final diagnoses, the children were normal/healthy (64%), diagnosed with Hashimoto thyroiditis (30%), nodular thyroid disease (3%), Graves disease (2%) and isolated increase of TSH was related to obesity in 5 patients (1%). DISCUSSION AND CONCLUSION: It is essential to evaluate children with abnormal thyroid function test results with detailed history and physical examination. Besides, the thyroid function tests should be performed with reliable and sensitive methods in standardized laboratories to reach the correct diagnosis in these children.

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Characterization of Hashimoto’s thyroiditis in Sudanese children: a cross-sectional study at Gaafar Ibn Auf Hospital, Khartoum

Fadlalbari¹,

Musa²,

Hassan³

et al. 2023

Pan Afr Med J

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Introduction literature on Hashimoto´s thyroiditis, the common thyroid illness in the young populations, in Sudan and Africa is scarce. We aimed to study its clinical profile and outcome among Sudanese children and adolescents. Methods records of 73 patients were reviewed. Data related to demographics, presenting features, family history and coexistence of autoimmune diseases, physical examination findings, and biochemical progression over time were obtained. Results patients´ mean age at the diagnosis was 10.6 ± 2.9 years, 80.8% (n = 59) of them were female and 83.6% (n = 61) were residing in iodine-sufficient areas. The commonest presenting features were thyromegaly and fatigability (79.5%, n = 58 and 43.8%, n = 32, respectively) after an illness duration of 0.5-48 months. Autoimmune comorbidities were documented in 8.2% (n = 6) of our series and more than half (53.4%, n = 39) of them were pre-pubertal at the diagnosis. Sixty point three percent (60.3%) (n = 44), 20.5% (n = 15), 13.7% (n = 10) and 5.5% (n = 4) of patients presented with overt hypothyroidism, sub-clinical hypothyroidism, euthyroidism and hyperthyroidism respectively, and there were no significant differences in the clinical profile between them. In patients’ continued follow-up, 94.1% (n = 32/34) of those presented with overt hypothyroidism required levothyroxine therapy to maintain euthyroidism for 0.5-13 years, while 85.7% (n = 6/7) of those with euthyroidism remained so for 0.5-6 years. Remission was reported in all hyperthyroid patients and in only 5.9% (n = 2/34) of those with overt hypothyroidism at diagnosis. The majority of our patients with subclinical hypothyroidism were treated with levothyroxine and continued to be euthyroid for 10 months to 13 years. Conclusion goiter was the commonest presenting feature of Hashimoto´s thyroiditis. The majority of patients had overt or subclinical hypothyroidism and almost all of them required long-term levothyroxine therapy.

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Çocuk ve ergenlerde Hashimoto tiroiditi: klinik ve laboratuvar bulgularının değerlendirilmesi

Cited by 6 publications

References 20 publications

Retrospective Analysis of Hashimoto’s Thyroiditis in Children and Adolescents: A Single Center Experience

Retrospective Analysis of Hashimoto’s Thyroiditis in Children and Adolescents: A Single Center Experience

The Characteristics of Children with Abnormalities Detected in Thyroid Function Tests, and Distribution of Diagnoses

Characterization of Hashimoto’s thyroiditis in Sudanese children: a cross-sectional study at Gaafar Ibn Auf Hospital, Khartoum

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