CocoSoft: educational software for automation in the analytical chemistry laboratory

Cocovi-Solberg, David J.; Miró, Manuel

doi:10.1007/s00216-015-8834-8

Cited by 38 publications

(19 citation statements)

References 12 publications

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“…The freeware CocoSoft 6.1 10,11 controlled all fluidic actuators, compensated the pump backlash, triggered the detector start through contact closure and acquired the pressure measurements for real-time smart control (see Section 2.3 ‘Sorbent manipulation and smart control’).…”

Section: Methodsmentioning

confidence: 99%

Sample preparation under turbulent flow with renewable sorbent

Cocovi-Solberg

Schnidrig²

2021

J. Anal. At. Spectrom.

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Section: Methodsmentioning

confidence: 99%

Sample preparation under turbulent flow with renewable sorbent

Cocovi-Solberg

Schnidrig²

2021

J. Anal. At. Spectrom.

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“…The flow system was controlled with the software Cocosoft 4.5, kindly provided by Dr. D.J. Cocoví (FITrace group, University of the Balearic Islands, [ 49 ]).…”

Section: Methodsmentioning

confidence: 99%

Lab-In-Syringe with Bead Injection Coupled Online to High-Performance Liquid Chromatography as Versatile Tool for Determination of Nonsteroidal Anti-Inflammatory Drugs in Surface Waters

2021

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We report on the hyphenation of the modern flow techniques Lab-In-Syringe and Lab-On-Valve for automated sample preparation coupled online with high-performance liquid chromatography. Adopting the bead injection concept on the Lab-On-Valve platform, the on-demand, renewable, solid-phase extraction of five nonsteroidal anti-inflammatory drugs, namely ketoprofen, naproxen, flurbiprofen, diclofenac, and ibuprofen, was carried out as a proof-of-concept. In-syringe mixing of the sample with buffer and standards allowed straightforward pre-load sample modification for the preconcentration of large sample volumes. Packing of ca. 4.4 mg microSPE columns from Oasis HLB® sorbent slurry was performed for each sample analysis using a simple microcolumn adapted to the Lab-On-Valve manifold to achieve low backpressure during loading. Eluted analytes were injected into online coupled HPLC with subsequent separation on a Symmetry C18 column in isocratic mode. The optimized method was highly reproducible, with RSD values of 3.2% to 7.6% on 20 µg L−1 level. Linearity was confirmed up to 200 µg L−1 and LOD values were between 0.06 and 1.98 µg L−1. Recovery factors between 91 and 109% were obtained in the analysis of spiked surface water samples.

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“…Instrumental control of the extraction system was done via USB using the open-source software Cocosoft, version 4.3 (FI-TRACE, University of the Balearic Islands). 37 The software is written in Python programming language and enables the use of variables, loops, routines, and conditionals and communication via the serial interface. Triggering of ICP OES activation and data registration was done by relay contact using the 24 V supply port of the MicroSIA instrument.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Fully Automatic In-Syringe Magnetic Stirring-Assisted Dispersive Liquid–Liquid Microextraction Hyphenated to High-Temperature Torch Integrated Sample Introduction System-Inductively Coupled Plasma Spectrometer with Direct Injection of the Organic Phase

et al. 2017

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A proof of concept study involving the online coupling of automatic dispersive liquid-liquid microextraction (DLLME) to inductively coupled plasma optical emission spectrometry (ICP OES) with direct introduction and analysis of the organic extract is herein reported for the first time. The flow-based analyzer features a lab-in-syringe (LIS) setup with an integrated stirring system, a Meinhard nebulizer in combination with a heated single-pass spray chamber, and a rotary injection valve, used as an online interface between the microextraction system and the detection instrument. Air-segmented flow was used for delivery of a fraction of the nonwater miscible extraction phase, 12 μL of xylene, to the nebulizer. All sample preparative steps including magnetic stirring assisted DLLME were carried out inside the syringe void volume as a size-adaptable yet sealed mixing and extraction chamber. Determination of trace level concentrations of cadmium, copper, lead, and silver as model analytes has been demonstrated by microextraction as diethyldithiophosphate (DDTP) complexes. The automatic LIS-DLLME method features quantitative metal extraction, even in troublesome sample matrixes, such as seawater, salt, and fruit juices, with relative recoveries within the range of 94-103%, 93-100%, and 92-99%, respectively. Furthermore, no statistically significant differences at the 0.05 significance level were found between concentration values experimentally obtained and the certified values of two serum standard reference materials.

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CocoSoft: educational software for automation in the analytical chemistry laboratory

Cited by 38 publications

References 12 publications

Sample preparation under turbulent flow with renewable sorbent

Sample preparation under turbulent flow with renewable sorbent

Lab-In-Syringe with Bead Injection Coupled Online to High-Performance Liquid Chromatography as Versatile Tool for Determination of Nonsteroidal Anti-Inflammatory Drugs in Surface Waters

Fully Automatic In-Syringe Magnetic Stirring-Assisted Dispersive Liquid–Liquid Microextraction Hyphenated to High-Temperature Torch Integrated Sample Introduction System-Inductively Coupled Plasma Spectrometer with Direct Injection of the Organic Phase

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