CoCoNuTs: A diverse subclass of Type IV restriction systems predicted to target RNA
Ryan T. Bell,
Harutyun Sahakyan,
Kira S. Makarova
et al.
Abstract:A comprehensive census of McrBC systems, a major form of prokaryotic Type IV restriction-modification (RM), followed by phylogenetic analysis, reveals their enormous abundance in diverse bacteria and archaea and a plethora of genomic associations. We focus on a previously uncharacterized branch, which we denote CoCoNuTs (coiled-coil nuclease tandems) for their salient features, the presence of extensive coiled-coil structures and tandem nucleases. The CoCoNuTs alone show extraordinary variety, with 3 distinct … Show more
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