Coconut oil supplementation during development reduces brain excitability in adult rats nourished and overnourished in lactation

Alves, Danielle Viana de Souza; Sousa, Mariana Séfora Bezerra; Tavares, Maryane Gabriela; Hornsby, Manuella Batista-de-Oliveira; Amâncio-dos-Santos, Ângela

doi:10.1039/d1fo00086a

Cited by 2 publications

(2 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, according to the Alves et al [33] body weight decreased in spontaneously hypertensive rats after 4 weeks of coconut oil supplementation. Additionally, some studies [16,27,34] have reported that coconut oil does not cause any changes in body weight. We think that the saturated fatty acids in the coconut oil may increase food consumption, which in turn may raise body weight.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Coconut oil ameliorates behavioral alterations in rat model of Alzheimer’s Disease via attenuating oxidative damage and cholinergic impairment and upregulating synaptic transmission

Belviranlı

Okudan

2023

Preprint

View full text Add to dashboard Cite

Alzheimer's disease (AD) is a chronic, progressive neurodegenerative condition marked by cognitive impairment. Although coconut oil has been shown to be potentially beneficial in reducing AD-related cognitive deficits, information on its mechanism of action is limited. Thus, we investigated the effects of coconut oil on spatial cognitive ability and non-cognitive functions in a rat model of AD induced by G-galactose (D-GAL) and aluminum chloride (AlCl3), and examined the changes in synaptic transmission, cholinergic activity, neurotrophic factors and oxidative stress in this process. The AD model was established by administering D-GAL and AlCl3 for 90 days, while also supplementing with coconut oil during this time. Cognitive and non-cognitive abilities of the rats were evaluated at the end of the 90-day supplementation period. In addition, biochemical markers related to the pathogenesis of the AD were measures in the hippocampus tissue. Exposure to D-GAL/AlCl3 resulted in a reduction in locomotor activity and exploratory behavior, an elevation in anxiety-like behavior, and an impairment of spatial learning and memory. The aforementioned behavioral disturbances were observed to coincide with increased oxidative stress and cholinergic impairment, as well as reduced synaptic transmission and levels of neurotrophins in the hippocampus. Interestingly, treatment with coconut oil attenuated all the neuropathological changes mentioned above. These findings suggest that coconut oil shows protective effects against cognitive and non-cognitive impairment, AD pathology markers, oxidative stress, synaptic transmission, and cholinergic function in a D-GAL/AlCl3-induced AD rat model.

show abstract

Section: Discussionmentioning

confidence: 99%

“…The post hoc test showed that the zone transition counts were lower in the AD group than in the C, CO and AD + CO groups. Additionally, it was lower in the AD + CO group than in the CO group (F (3,27) = 27.913; p = 0.000) (Fig. 3G).…”

Section: Exploratory Behaviormentioning

confidence: 91%

Coconut oil ameliorates behavioral alterations in rat model of Alzheimer’s Disease via attenuating oxidative damage and cholinergic impairment and upregulating synaptic transmission

Belviranlı

Okudan

2023

Preprint

View full text Add to dashboard Cite

show abstract

Coconut oil ameliorates behavioral and biochemical alterations induced by D-GAL/AlCl3 in rats

Belviranlı,

Okudan

2024

Brain Research

View full text Add to dashboard Cite

Coconut oil supplementation during development reduces brain excitability in adult rats nourished and overnourished in lactation

Abstract: Coconut oil has been considered as a therapeutic alternative in several pathologies, but there is limited information regarding its effects on brain functioning.

Cited by 2 publications

References 43 publications

Coconut oil ameliorates behavioral alterations in rat model of Alzheimer’s Disease via attenuating oxidative damage and cholinergic impairment and upregulating synaptic transmission

Coconut oil ameliorates behavioral alterations in rat model of Alzheimer’s Disease via attenuating oxidative damage and cholinergic impairment and upregulating synaptic transmission

Coconut oil ameliorates behavioral and biochemical alterations induced by D-GAL/AlCl3 in rats

Contact Info

Product

Resources

About