Cocoa Consumption and Blood Pressure in Middle-Aged and Elderly Subjects: a Meta-Analysis

Jafarnejad, Sadegh; Salek, Mina; Clark, Cain C. T.

doi:10.1007/s11906-019-1005-0

Cited by 30 publications

(20 citation statements)

References 45 publications

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“…Genetic variations in the CLOCK gene are connected with blood pressure and cardiovascular disorders in humans [ 37 , 38 , 39 , 40 ]. Here, an association of rs11932595, located in the CLOCK gene’s intronic region, with systolic and diastolic blood pressure was found in women and with BMI in men.…”

Section: Discussionmentioning

confidence: 99%

“…CLOCK knock-out and CLOCK mutant mice show an essential role of CLOCK in regulating blood pressure and kidney function [ 38 , 39 , 40 ]. Mice with a knock-out or mutated CLOCK gene have lower blood pressure, plasma aldosterone levels, changed urinary sodium excretion, and a higher incidence of diabetes insipidus than control mice [ 37 , 38 , 39 , 40 ]. A possible mechanism contributing to this is the reduced level of 20-hydroxyeicosatetraenoic acid in the CLOCK knock-out mice’s urine [ 37 , 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

“…Mice with a knock-out or mutated CLOCK gene have lower blood pressure, plasma aldosterone levels, changed urinary sodium excretion, and a higher incidence of diabetes insipidus than control mice [ 37 , 38 , 39 , 40 ]. A possible mechanism contributing to this is the reduced level of 20-hydroxyeicosatetraenoic acid in the CLOCK knock-out mice’s urine [ 37 , 39 , 40 ]. The 20-hydroxyeicosatetraenoic acid is essential in regulating blood pressure and blood flow [ 37 , 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

“…A possible mechanism contributing to this is the reduced level of 20-hydroxyeicosatetraenoic acid in the CLOCK knock-out mice’s urine [ 37 , 39 , 40 ]. The 20-hydroxyeicosatetraenoic acid is essential in regulating blood pressure and blood flow [ 37 , 39 , 40 ]. The CLOCK protein has also been associated with diabetes and obesity due to a mutation that prevents CLOCK from binding to DNA and activating target genes.…”

Section: Discussionmentioning

confidence: 99%

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Sex Differences in Circadian Clock Genes and Myocardial Infarction Susceptibility

Škrlec

Talapko

Juzbašić

et al. 2021

JCDD

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The growing body of evidence shows a significant difference in the circadian rhythm of cardiovascular disease based on biological sex. The incidence of cardiovascular disease varies between women and men. Additionally, biological sex is vital for the timely application of therapy—chronotherapy, which benefits both sexes. This study aimed to examine the potential difference of single nucleotide polymorphisms (SNPs) of the circadian rhythm genes ARNTL, CLOCK, CRY2 and PER2 in women and men with myocardial infarction. A cross-sectional study was conducted, including 200 patients with myocardial infarction. Altogether, ten single nucleotide polymorphisms in the ARNTL, CLOCK, CRY2 and PER2 genes were analyzed. The Chi-square test yielded statistically significant differences in CLOCK gene rs11932595 polymorphism in a recessive genotype model between women and men with a p-value of 0.03 and an odds ratio 2.66, and a corresponding 95% confidence interval of 1.07 to 6.66. Other analyzed polymorphisms of the circadian rhythm genes ARNTL, CRY2, and PER2 did not significantly differ between the sexes. According to the study’s current results, the CLOCK gene’s genetic variability might affect myocardial infarction concerning biological sex.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Sex Differences in Circadian Clock Genes and Myocardial Infarction Susceptibility

Škrlec

Talapko

Juzbašić

et al. 2021

JCDD

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“…This was studied by Rosell and colleagues, who showed that circulating tissue factor-positive extracellular vesicles levels are higher in patients with COVID-19, and also were correlated with disease severity and mortality [ 50 ]. Gavriilaki and colleagues noted that the clinical manifestations of endothelial dysfunction are extensive and include microvascular lung thrombosis, venous thrombosis (e.g., pulmonary embolism, deep vein thrombosis, cerebral venous thrombosis), arterial thrombosis (e.g., cardiovascular or cerebral vascular disease, acute limb ischemia), renal disease, and neurological complications (e.g., encephalopathy) [ 51 ]. As such, antithrombotic drugs have been proposed as potential adjunctive therapies for the prevention of COVID-19-associated thrombosis [ 52 ].…”

Section: Complement In Sars-cov-2mentioning

confidence: 99%

Targeting the Complement Cascade in the Pathophysiology of COVID-19 Disease

Powell

2021

JCM

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Severe coronavirus disease 2019 causes multi-organ dysfunction with significant morbidity and mortality. Mounting evidence implicates maladaptive over-activation of innate immune pathways such as the complement cascade as well as endothelial dysfunction as significant contributors to disease progression. We review the complement pathways, the effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on these pathways, and promising therapeutic targets in clinical trials.

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The effect of cocoa/dark chocolate consumption on lipid profile, glycemia, and blood pressure in diabetic patients: A meta‐analysis of observational studies

Darand

Oghaz

Hadi

et al. 2021

Phytotherapy Research

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Due to the increasing rate of cardiovascular disease and related risk factors in the worldin recent decades, the present meta-analysis was performed to investigate the effects ofcocoa/chocolate consumption on lipid profile, glycemia, and blood pressure control in diabetic patients. A systematic search of the databases PubMed, Scopus, Web of Science, and Cochran Library was performed up to July 2020. All randomized controlled trials (RCTs) using cocoa/dark chocolate in diabetic patients were included in the study. The search results were limited to English-language publications. Eight RCTs, including 433 participants, were selected for this meta-analysis. Pooled analysis indicated a significant reduction in low-density lipoprotein cholesterol LDL-c levels (WMD: À15.49 mg/dl; 95% CI: À24.56, À6.42, p = .001) and fasting blood sugar (FBS) concentrations (WMD: À6.88 mg/dl; 95% CI: À13.28, À0.48, p = .03) following cocoa/dark chocolate consumption. The analysis of papers included in current study indicates that the consumption of cocoa/dark chocolate reduced the serum fasting blood glucose (FBS) and LDL cholesterol concentrations. However, further high quality trials are essential for confirming the clinical efficacy of cocoa/dark chocolate consumption on complete metabolic profile.

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Cocoa Consumption and Blood Pressure in Middle-Aged and Elderly Subjects: a Meta-Analysis

Cited by 30 publications

References 45 publications

Sex Differences in Circadian Clock Genes and Myocardial Infarction Susceptibility

Sex Differences in Circadian Clock Genes and Myocardial Infarction Susceptibility

Targeting the Complement Cascade in the Pathophysiology of COVID-19 Disease

The effect of cocoa/dark chocolate consumption on lipid profile, glycemia, and blood pressure in diabetic patients: A meta‐analysis of observational studies

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