Cockroach allergens and asthma

Arruda, L. Karla; Vailes, Lisa D.; Ferriani, Virgínia Paes Leme; Santos, Antônio Cardozo dos; Pomés, Anna; Chapman, Martin D.

doi:10.1067/mai.2001.112854

Cited by 221 publications

(196 citation statements)

References 71 publications

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“…11,[24][25][26] Asthma and sensitization to cockroach allergen are widely known to be associated. [27][28][29] High exposure to cockroach allergen is a risk factor for both asthma medication use and asthma-related hospitalizations. 26 In addition, the presence of dust mite, cat, cockroach, and mouse allergen in the home have been found to be related to airway hyperresponsivesness 30 and sensitization to dust mite and cat allergen are related to wheezing.…”

Section: Asthma and Indoor Allergensmentioning

confidence: 99%

Are Building-Level Characteristics Associated with Indoor Allergens in the Household?

et al. 2011

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Building-level characteristics are structural factors largely beyond the control of those who live in them. We explored whether building-level characteristics and indoor allergens in the household are related. We examined the relationship between building-level characteristics and indoor allergens: dust mite, cat, cockroach, and mouse. Building-level characteristics measured were presence of pests (seeing cockroaches and rodents), building type (public housing, buildings zoned commercially and residentially, and building size), and building condition (building age and violations). Allergen cutpoints were used for categorical analyses and defined as follows: dust mite: 90.25 μg/g; cat: 91 μg/g; cockroach: 91 U/g; mouse: 91.6 μg/g. In fully adjusted linear analyses, neither dust mite nor cat allergen were statistically significantly associated with any building-level characteristics. Cockroach allergen was associated with the presence of cockroaches (2.07; 95% CI, 1.23, 3.49) and living in public housing (2.14; 95% CI, 1.07, 4.31). Mouse allergen was associated with the presence of rodents (1.70; 95% CI, 1.29, 2.23), and building size: living in a low-rise (G8 floors; 0.60; 95% CI, 0.42, 0.87) or high-rise (8+floors; 0.50; 95% CI, 0.29, 0.88; compared with house/duplex). In fully adjusted logistic analyses, cat allergen was statistically significantly associated with living in a high-rise (6.29; 95% CI, 1.51, 26.21; compared with a house/duplex). Mouse allergen was associated with living in public housing (6.20; 95% CI, 1.01, 37.95) and building size: living in a low-rise (0.16; 95% CI, 0.05, 0.52) or high-rise (0.06; 95% CI, 0.01, 0.50; compared with a house/duplex). Issues concerning building size and public housing may be particularly critical factors in reducing asthma morbidity. We suggest that future research explore the possible improvement of these factors through changes to building code and violations adherence, design standards, and incentives for landlords.

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Section: Asthma and Indoor Allergensmentioning

confidence: 99%

Are Building-Level Characteristics Associated with Indoor Allergens in the Household?

et al. 2011

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“…Indeed, it has been found that cockroach antigen is the most common asthma-inducing allergen in children in inner cities. 4,5) Cockroaches are controlled primarily with synthetic organic insecticides in the form of baits, aerosols, foggers, and crack treatments. 6,7) At present, chemical-based methods for cockroach management generally involve repeated applications of residual insecticides (e.g., dichlorvos, chlorpyrifos, propoxur, and pyrethroids), 8) stomach poisons (e.g., hydramethylnon, boric acid, and sulfluramid), 9) and insect growth regulators (e.g., noviflumuron and lufenuron).…”

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confidence: 99%

Repellent activity of citrus oils against the cockroaches Blattella germanica, Periplaneta americana and P. fuliginosa

et al. 2009

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The repellent efficacy of 17 essential oils against the German cockroach, Blattella germanica was examined using a T-tube olfactometer. Five oils repelled B. germanica with good efficacy, ranging from 70.0 to 96.7%. Four of these oils, grapefruit, lemon, lime, and orange, were from the citrus family Rutaceae. These citrus essential oils showed similar repellent activity against two more cockroach species, such as Periplaneta americana and P. fuliginosa. Gas chromatography (GC) and GC-mass spectrometry analyses revealed that the major components responsible for the repellent activity of the citrus oils were limonene, b-pinene and g-terpinene. Limonene appears to be the main component responsible for the repellent activity rather than b-pinene and g-terpinene. The repellent efficacy of these components varied with different doses and the cockroach species tested. It is likely that minor components of the oils also contributed to the overall repellent activity of citrus essential oils, except orange oil. The activity of orange oil is almost solely attributed to the activity of limonene. Also, the repellent activity of citrus oil and that of each of the terpenoids makes little difference to the efficacy of a repellant against the three species of cockroaches.

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“…Sensitization to cockroach allergens can lead to the development of allergic respiratory diseases, including asthma, in susceptible individuals [1]. In the US, this problem is particularly important in inner city areas where infestation by the German cockroach (Blattella germanica) is common [2][3][4][5].…”

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IgE reactivity of tandem repeats derived from cockroach allergen, Bla g 1

Pomés

Vailes

Helm

et al. 2002

European Journal of Biochemistry

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Sensitization to cockroach allergens is associated with the development of asthma. Bla g 1 is a German cockroach allergen that shows allergenic cross‐reactivity with American cockroach allergen, Per a 1, and has a molecular structure composed of multiple tandem amino‐acid repeats. Two consecutive repeats are not identical but form a duplex that constitutes a basic molecular unit of Bla g 1. By molecular mass, purified natural Bla g 1 would contain approximately two duplexes. We investigated the pattern of IgE antibody binding to this repeated structure, and whether one or two duplexes are sufficient for IgE binding. Recombinant (r)Bla g 1 duplexes were expressed in Escherichia coli and in Pichia pastoris, and analyzed for monoclonal antibody and IgE antibody binding by ELISA and/or immunoblotting. Optimal rBla g 1 expression was obtained using methanol‐inducible P. pastoris (> 95% pure protein, yield ≈ 48 mg·L−1), and rBla g 1 was produced as multiple molecular forms of molecular mass 43, 32, 21 and 6 kDa, that were the result of proteolytic cleavage. There was an excellent correlation between IgE antibody binding to natural and recombinant Bla g 1 (r = 0.91, n = 29, P < 0.001), and immunoblot analysis showed that a single Bla g 1 duplex was sufficient for IgE antibody binding. The rBla g 1 is suitable for structural studies and a candidate for clinical use in diagnosis of cockroach allergy and development of new forms of immunotherapy.

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Cockroach allergens and asthma

Cited by 221 publications

References 71 publications

Are Building-Level Characteristics Associated with Indoor Allergens in the Household?

Are Building-Level Characteristics Associated with Indoor Allergens in the Household?

Repellent activity of citrus oils against the cockroaches Blattella germanica, Periplaneta americana and P. fuliginosa

IgE reactivity of tandem repeats derived from cockroach allergen, Bla g 1

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