Cochlear Otosclerosis (Otospongiosis): A Case Report

Abstract

9. Swarts JD , Mandell DW, Berman SE , et al. Cochear otos. clerosis(Otospongiosis) analysis w ith aud iometric correlat ion Radiology 1985 ; 155 : 147-150 10. Malee MF, Valvassori GE , Deitch RL , et al. Use 01 CT in the eval uation 01 cochl ear otosclerosis. Radiology 1985 ; 156 703.714 11. Seltzer S, Mark AS. Contrast enhancement 01 the labyrinth on MR Scans in patients with sudden hearing 1055 and vertigo Evidence 01 labyr inthi al di5ease. AJNR 1991 ; 12:13.16 % ω 윤은겸 측두골 CT상 관잘된 와우 이경화증Otosclerosis occurs when the normal ivory-like endochondral bone of the otic capsule is replaced by foci of spongy vascular irregular new bone. Eventually these foci of haversian bone become more solid. There are tw。 types of otosclerosis : fenestral and retrofenestral or cochlear. The cochlear type is much less common and rarely occurs without fenestral involvement. Otosclerosis occurs very rarely in blacks and orientals; in 。tolaryngologic articles in Korea there are few reports of otosclerosis , and then only the fenestral type. This is a case report of cochlear otosclerosis that can be diagnosed on temporal bone CT.

PTP Inhibitor V Inhibits Dual‐specificity Phosphatase 22 (DUSP22) Activity

“…12,13 PTP inhibitor V, also known as PHPS1, has the formula 4-(N'-(3-(4-nitrophenyl)-5-oxo-1-phenyl-1,5-dihydro-pyrazol-(4Z)-ylidene)-hydrazino)-benzenesulfonic acid, and was determined as the specific inhibitor for SHP-2 and inhibited SHP-2-dependent cellular functions in the various tumor cell lines (Figure 1). 14 Likewise, DUSP13A, DUSP13B, DUSP14, and protein tyrosine phosphatase non-receptor type 2 (PTPN2) were reported as additional targets of the PTP inhibitor V. [15][16][17][18] Since PTP inhibitor V might be suitable as a starting point for further development of PTP inhibitors, it is important to investigate whether this inhibitor is involved in the regulation of more PTPs. Therefore, we performed in vitro phosphatase assays with seven additional human PTPs to search for more PTP inhibitor V targets.…”