Cochlear Function of Guinea Pigs with Experimental Chronic Renal Failure

Abstract

This study aimed to evaluate electrophysiologically the cochlear function of guinea pigs that underwent a five-sixths nephrectomy and, additionally, to explore the synergistic action between chronic renal failure (CRF) and noise. Cochlear potentials were recorded at 1, 2, and 3 months postoperatively. Slight changes in compound action potential and cochlear microphonics were seen at 1 month postoperative, while moderate and profound changes were seen at 2 and 3 months. Endocochlear potential showed no significant reduction. The results indicate that CRF may be an etiologic factor for cochlear dysfunction and that the hair cells seem likely to be a main site of the lesion. One-month-postoperative animals were exposed to a broadband noise. In contrast to control animals, the test animals demonstrated no recovery from the decrease in compound action potential and cochlear microphonics that occurred immediately after noise exposure. This suggests a synergistic interaction between CRF and noise.

Increased risk of getting sudden sensorineural hearing loss in patients with chronic kidney disease: A population‐based cohort study

“…A general consensus of animal models was that cochlea is the site of auditory lesion in induced CRF 20. For example, Ohashi et al found that, with greater renal damage, the amplitudes of the cochlear potentials N1 and CM were smaller and latency of N1 was prolonged, but the AP was within normal range 21. Ikeda et al measured the cochlear potentials of guinea pigs with induced renal failure at 1, 2, and 3 months postoperatively 22.…”

“…14,[20][21][22][23][24][25][26] Evidence from induced renal insufficiency in animal studies has constantly reported the correlation between CRF and sensorineural hearing impairment. [20][21][22][23] A general consensus of animal models was that cochlea is the site of auditory lesion in induced CRF. 20 For example, Ohashi et al found that, with greater renal damage, the amplitudes of the cochlear potentials N1 and CM were smaller and latency of N1 was prolonged, but the AP was within normal range.…”

“…Meanwhile, both animal studies and human temporal bone studies have consistently reported a supporting evidence for the correlations between CKD and risk of developing SSHL. 14,[20][21][22][23][24][25][26] Evidence from induced renal insufficiency in animal studies has constantly reported the correlation between CRF and sensorineural hearing impairment. [20][21][22][23] A general consensus of animal models was that cochlea is the site of auditory lesion in induced CRF.…”

Disability of Hearing Impairment Is Positively Associated With Urine Albumin/Creatinine Ratio in Korean Adults: The 2011–2012 Korea National Health and Nutrition Examination Survey

“…Especially, chronic kidney disease (CKD) is a well-known risk factor for atherosclerosis, and animal studies [3,4] have reported an association between uremia and cochlear dysfunction. Recently, there are two studies regarding the association between CKD and HL.…”

Biology and Diseases of Guinea Pigs

“…Nephrosclerosis, seen occasionally as an incidental finding in aged guinea pigs, is characterized by weakness, anemia, dilute urine, and increased blood urea nitrogen and creatinine (Baggio et al, 1997). In guinea pigs, chronic renal failure may predispose to cochlear dysfunction, especially in the hair cells (Ohashi et al, 1999). This segmental to diffuse interstitial fibrosis causes the kidney to have an irregular surface.…”