Cochlear Adaptation In Guinea Pigs

Direct comparison between properties of adaptation of the auditory nerve and the ventral cochlear nucleus in response to repetitive clicks

“…2 and 4), the adaptive properties of the second negative component of the ANEPs, as found in the present investigation, matched those of the first negative component in the same experimental conditions (Loquet and Rouiller, 2002;Loquet et al, 2003) and those previously reported for the AN (e.g. Peake et al, 1962a,b;Eggermont and Spoor, 1973;Harris and Dallos, 1979;Schreiner, 1990, 1991;Westerman and Smith, 1984). Therefore, statements about the similarities in response patterns displayed by AN fibers and neurons typically found in the VCN can be extended in the sense that they do not only respond alike to single tone bursts but also in response to repetitive acoustic stimulation, even when stimulation rate and intensity are varied.…”

“…Adaptation properties of primary auditory neurons have been assessed by several authors having recorded either compound action potentials (Peake et al, 1962a,b;Eggermont and Spoor, 1973;Gorga and Abbas, 1981;Abbas, 1984;Schreiner, 1990, 1992) or firing patterns from single auditory-nerve fibers (Kiang et al, 1965a;Smith and Zwislocki, 1975;Smith, 1977Smith, , 1979Harris and Dallos, 1979;Westerman and Smith, 1984;Yates et al, 1985;Rhode and Smith, 1985;Chimento and Schreiner, 1991;Javel, 1996;Taberner and Liberman, 2005), in response to either long pure tones or trains of repetitive tone bursts or clicks. The adaptation time course displayed by primary auditory neurons was described to consist essentially of three stages: a rapid decrease of compound-action-potential amplitude or firing rate during the first few milliseconds of stimulation (rapid adaptation), followed by a slower decrease (short-term adaptation) and, finally, a steady state.…”

The I' potential of the human auditory brainstem response to paired click stimuli

“…as with amplitude, the increase In latency was directly related to increased stimulus intensity and duration. Furthennore, Eggermont & Spoor (1973a) observed the distinct widening oi N| (of the AP complex, Ni/Pl/N2). It was also observed that peak N, widened as a function of a decrease of the ISI.…”

“…1981: Eggermont, 1985. Eggermont & Spoor (1973a) summarized the effects of a forward-masking paradigm as being highly dependent on the ISI. stimulus intensity and stimulus duration.…”

“…once again, consulted. Eggermont & Spoor (1973a) were the first to describe N| in both an unadapted and adapted condition with respect to morphology. They used a Gaussian distribution function to describe the shape of an unadapted N|.…”