Coccidioidomycosis in Renal Transplant Recipients

Antony, Suresh J.; Dummer, Stephen; Mcneil, Keith K.; Salas, I. Alonso

doi:10.1097/01.idc.0000179883.64882.41

Cited by 10 publications

(9 citation statements)

References 23 publications

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“…Four had pulmonary infection only, and 3 had pulmonary involvement with dissemination documented only to skin or osteoarticular structures. In contrast, other series from endemic areas for coccidioidomycosis found a higher frequency of disseminated disease among SOT recipients . Those reports that consist of greater numbers of patients likely, reflect more accurately the types of disease caused by Coccidioides species in the transplant population .…”

Section: Discussionmentioning

confidence: 82%

Endemic fungal infections in solid organ and hematopoietic cell transplant recipients enrolled in the Transplant‐Associated Infection Surveillance Network (TRANSNET)

Kauffman

Freifeld

Andes

et al. 2014

Transplant Infectious Dis

148

134

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Background Invasive fungal infections are a major cause of morbidity and mortality among solid organ transplant (SOT) and hematopoietic cell transplant (HCT) recipients, but few data have been reported on the epidemiology of endemic fungal infections in these populations. Methods Fifteen institutions belonging to the Transplant-Associated Infection Surveillance Network prospectively enrolled SOT and HCT recipients with histoplasmosis, blastomycosis, or coccidioidomycosis occurring between March 2001 and March 2006. Results A total of 70 patients (64 SOT recipients and 6 HCT recipients) had infection with an endemic mycosis, including 52 with histoplasmosis, 9 with blastomycosis, and 9 with coccidioidomycosis. The 12-month cumulative incidence rate among SOT recipients for histoplasmosis was 0.102%. Occurrence of infection was bimodal; 28 (40%) infections occurred in the first 6 months post transplantation, and 24 (34%) occurred between 2 and 11 years post transplantation. Three patients were documented to have acquired infection from the donor organ. Seven SOT recipients with histoplasmosis and 3 with coccidioidomycosis died (16%); no HCT recipient died. Conclusions This 5-year multicenter prospective surveillance study found that endemic mycoses occur uncommonly in SOT and HCT recipients, and that the period at risk extends for years after transplantation.

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Section: Discussionmentioning

confidence: 82%

Endemic fungal infections in solid organ and hematopoietic cell transplant recipients enrolled in the Transplant‐Associated Infection Surveillance Network (TRANSNET)

Kauffman

Freifeld

Andes

et al. 2014

Transplant Infectious Dis

148

134

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“…In addition, a systematic review of renal transplant recipients with TB suggested that INH prophylaxis was less likely to develop active TB compared with those who did not receive this treatment ( Adamu et al, 2014 ). However, many transplant centers do not routinely use INH prophylaxis because of an increased risk of liver toxicity after INH treatment ( Antony et al, 1997 ). Our study showed that INH prophylaxis can be beneficial in reducing the risk of TB infection and has no difference in side effects.…”

Section: Discussionmentioning

confidence: 99%

Chemoprophylaxis for the prevention of tuberculosis in kidney transplant recipients: A systematic review and meta-analysis

Yuan

Chao

et al. 2023

Front. Pharmacol.

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Background: A systematic review and meta-analysis was performed to investigate the efficacy and safety of isoniazid (INH) prophylaxis to prevent tuberculosis (TB) infection in kidney transplant recipients (KTRs).Methods: Web of Science, SCOPUS, and PubMed were searched to identify relevant studies that compared the effects among patients who received INH prophylaxis after transplantation.Results: A total of 13 studies (involving 6,547 KTRs) were included in our analysis. We found that the risk of active TB infection (RR: 0.35, 95%CI 0.27–0.45, p < 0.01) for KTRs was lower in the INH treatment group than in those without prophylaxis. However, there was no significant difference between the two groups in mortality (RR: 0.93, 95%CI 0.67–1.28, p = 0.64), acute rejection (RR: 0.82, 95%CI 0.44–1.51, p = 0.52), and hepatotoxicity (RR: 1.25, 95%CI 0.94–1.65, p = 0.12).Conclusion: Isoniazid prophylaxis is a safe and effective for KTRs on reactivation of latent TB infection.

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“…Episodes of occasional of arthralgias are common with a primary pulmonary source as well [5]. The risk factors associated with severe disseminated infection are immunosuppression such as, AIDS, solid organ transplant recipients, lymphomas, or prolonged steroid use [6]. While the vast majority of Coccidioidomycosis infections have a primary pulmonary source, primary Coccidioidomycosis of the larynx is a very rare and unusual presentation.…”

Section: Isolated Laryngeal Coccidioidomycosis -A Case Report and Review Of The Literature Antony N *mentioning

confidence: 99%

Isolated Laryngeal Coccidioidomycosis - A Case Report and Review of the Literature

Antony¹

2015

Journal of Immunology and Infectious Diseases

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Coccidioidomycosis involving the larynx is a rare occurrence which seems to present with non-specific upper airway symptoms. The diagnosis is made by tissue biopsy and the treatment is usually fluconazole for 6-12 months depending on the clinical presentation. In unusual presentations of laryngeal problems clinicians should consider Coccidioidomycosis, especially in endemic regions.We present a 59-year-old Hispanic female resident of West Texas who presented with symptoms of hoarseness, sore throat, and low-grade fevers for 2-3 months. She had been evaluated by her primary care physician who had treated her with several courses of antibiotics including quinolones, azithromycin, and cephalosporins. Because of the persistence of her symptoms she was sent to an otolaryngologist. On examination her temperature was 98.4 F, blood pressure was 124/78 mm Hg, and pulse 78 bpm. Laryngoscope revealed a soft tissue mass along the left side of the airway just above the vocal cords. No cervical lymphadenopathy was noted. The rest of the examination was unremarkable.

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Coccidioidomycosis in Renal Transplant Recipients

Cited by 10 publications

References 23 publications

Endemic fungal infections in solid organ and hematopoietic cell transplant recipients enrolled in the Transplant‐Associated Infection Surveillance Network (TRANSNET)

Endemic fungal infections in solid organ and hematopoietic cell transplant recipients enrolled in the Transplant‐Associated Infection Surveillance Network (TRANSNET)

Chemoprophylaxis for the prevention of tuberculosis in kidney transplant recipients: A systematic review and meta-analysis

Isolated Laryngeal Coccidioidomycosis - A Case Report and Review of the Literature

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