2004
DOI: 10.1128/cmr.17.4.804-839.2004
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Coccidioidomycosis: Host Response and Vaccine Development

Abstract: Coccidioidomycosis is caused by the dimorphic fungi in the genus Coccidioides. These fungi live as mycelia in the soil of desert areas of the American Southwest, and when the infectious spores, the arthroconidia, are inhaled, they convert into the parasitic spherule/endospore phase. Most infections are mild, but these organisms are frank pathogens and can cause severe lethal disease in fully immunocompetent individuals. While there is increased risk of disseminated disease in certain racial groups and immunoco… Show more

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Cited by 185 publications
(231 citation statements)
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“…The spherules increase in size and produce hundreds of endospores, which are subsequently released into the tissue and form new spherules, thereby continuing the life cycle ( Figure 2). 3 When the host inhales Coccidioides arthroconidia, the normal immune response occurs in 2 phases. 3 The early immune response consists of an influx of neutrophils, eosinophils, monocytes, and natural killer cells.…”
Section: Mycology and Immunologymentioning
confidence: 99%
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“…The spherules increase in size and produce hundreds of endospores, which are subsequently released into the tissue and form new spherules, thereby continuing the life cycle ( Figure 2). 3 When the host inhales Coccidioides arthroconidia, the normal immune response occurs in 2 phases. 3 The early immune response consists of an influx of neutrophils, eosinophils, monocytes, and natural killer cells.…”
Section: Mycology and Immunologymentioning
confidence: 99%
“…3 When the host inhales Coccidioides arthroconidia, the normal immune response occurs in 2 phases. 3 The early immune response consists of an influx of neutrophils, eosinophils, monocytes, and natural killer cells. After the arthroconidia become spherules, the early innate response is ineffective, and the cell-mediated immune response begins.…”
Section: Mycology and Immunologymentioning
confidence: 99%
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