Coccidioidomycosis

Cox, Rebecca A.

doi:10.1007/978-1-4899-2400-1_8

Cited by 19 publications

(5 citation statements)

References 188 publications

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“…The assumption that the signal peptide lacks a B-cell-reactive epitope is supported by an earlier finding that sera from patients with active coccidioidomycosis recognized the recombinant GST-Ag2/PRA(1-194) fusion protein in immunoblots but did not react with a recombinant GST-Ag2/PRA(1-18) peptide (34). The protective capacity of Ag2/PRA(1-18) DNA in the absence of a detectable antibody response is consistent with earlier reports that antibodies do not appear to have a protective role in host resistance to C. immitis (6,9).…”

Section: Discussionsupporting

confidence: 90%

“…Evidence from clinical and experimental investigations revealed that the severity of coccidioidomycosis directly correlates with depressed cell-mediated immunity to coccidioidal antigens (2,4,(7)(8)(9)(10)25). Recovery from primary infection is associated with strong cell-mediated immune responses to C. immitis and is accompanied by life-long immunity to exogenous reinfection (6,33). Therefore, developing a vaccine is a feasible and promising strategy against C. immitis in regions where this fungal pathogen is endemic.…”

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confidence: 99%

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Role of Signal Sequence in Vaccine-Induced Protection against Experimental Coccidioidomycosis

et al. 2002

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Section: Discussionsupporting

confidence: 90%

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confidence: 99%

Role of Signal Sequence in Vaccine-Induced Protection against Experimental Coccidioidomycosis

et al. 2002

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“…Keratin (from decaying carcasses, shed skin, and other sources) is widely distributed in the environment, and chytrids that use this substrate are well known (42). Furthermore, the ability to develop and reproduce saprophytically is common to many other fungal (54) (including chytrid [41]) and bacterial (55) pathogens. An epidemiologic model of a host-parasite system for pathogens that can reproduce saprophytically clearly shows a lowering of the host threshold population, allowing the pathogen to drive the host to extinction (55).…”

Section: Chytridiomycosis As the Cause Of Population Declinesmentioning

confidence: 99%

Emerging Infectious Diseases and Amphibian Population Declines

Daszak

Berger²,

Cunningham³

et al. 1999

Emerg. Infect. Dis.

806

680

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We review recent research on the pathology, ecology, and biogeography of two emerging infectious wildlife diseases, chytridiomycosis and ranaviral disease, in the context of host-parasite population biology. We examine the role of these diseases in the global decline of amphibian populations and propose hypotheses for the origins and impact of these panzootics. Finally, we discuss emerging infectious diseases as a global threat to wildlife populations.

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“…Coccidioidomycosis is a pulmonary fungal disease caused by dimorphic fungi in the genus Coccidioides (8,13). The cumulative interpretation of studies performed in humans and mice indicates that cell-mediated immune responses are essential in primary host defenses against Coccidioides and that recovery is associated with antigen-specific delayed-type hypersensitivity and the production of T helper 1 (Th1)-associated cytokines, such as gamma interferon (IFN-␥) and interleukin 2 (1, 2, 7-10, 19, 20).…”

mentioning

confidence: 99%