Coccidioides immitis meningitis with arthroconidia in cerebrospinal fluid: Reportof the first case and review of the arthroconidia literature

Meyer, Paul R.; Hui, Anthony N.; Biddle, Marjorie

doi:10.1016/s0046-8177(82)80253-0

Cited by 21 publications

(13 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, we describe different mycelial forms and chronic pulmonary coccidioidomycosis in patients with diabetes ( Figure 1a). Also, these mycelial forms were described in chronic and cavitary pulmonary, ventriculoperitoneal shunt, and different cases of Central nervous system (CNS) infections by other researchers (Dolan et al,1992;Hagman et al, 2000;Heidi et al, 2000;Klenschmidt-DeMasters et al, 2000;Meyer et al, 1982;Muñoz et al, 2004;Muñoz-Hernández et al 2008;Nosanchuk et al, 1998;Wages et al, 1995;Zepeda et al, 1998).…”

Section: Geotypingmentioning

confidence: 96%

Innovation of the Parasitic Cycle of Coccidioides spp.

Muñoz-Hernández¹,

Rivera²,

Palma-Cortés³

et al. 2012

Parasitology

View full text Add to dashboard Cite

Section: Geotypingmentioning

confidence: 96%

Innovation of the Parasitic Cycle of Coccidioides spp.

Muñoz-Hernández¹,

Rivera²,

Palma-Cortés³

et al. 2012

Parasitology

View full text Add to dashboard Cite

“…For example, hyphae are sometimes seen in coccidioidal pulmonary cavities and infrequently in tissues other than lung (94,152).…”

Section: Introductionmentioning

confidence: 99%

Serology of coccidioidomycosis

1990

View full text Add to dashboard Cite

Serologic tests have assisted in the diagnosis and prognosis of coccidioidomycosis for a half-century. The causative agent, Coccidioides immitis, is a dimorphic fungus existing in a hyphal form with arthroconidia in nature and in the usual culture. The arthroconidia represent the inhaled infective forms which in vivo and under special laboratory conditions form spherules which endosporulate. The culture filtrate/autolysate (coccidioidin) from the hyphal phase has provided antigens of suitable reliability for currently used serologic tests. These tests are primarily to determine the two major antibody responses: the early immunoglobulin M (IgM) response is useful in the diagnosis of acute primary coccidioidomycosis. Later, IgG is produced and usually outlasts the IgM, persisting in chronic coccidioidomycosis. The IgM is detectable by tube precipitin, a corresponding immunodiffusion, or latex particle agglutination tests. The pertinent antigen(s) is heat stable and pronase resistant and appears to be largely carbohydrate, mainly mannose with some 3-O-methyl mannose. The IgG detectable in the serum and other body fluids by complement fixation and a corresponding immuno-diffusion is useful in diagnosis, and its quantitation provides an indicator of progression of disease (increasing titer) or regression (decreasing titer). The pertinent antigen appears to be a heat-labile, pronase-sensitive protein which in an unreduced form has a molecular weight of 110,000. A third very useful serologic procedure is the exoantigen test for identification of putative cultures of C. immitis.

show abstract

“…These organisms can be identifi ed in tissue using silver, hematoxylin-eosin, and periodic acid-Schiff stains. Rarely, CSF can show mold forms of Coccidioides; such hyphal forms have been reported with [19,23] or without [24] the presence of foreign material (eg, ventricular shunts). Demonstration of mycelial forms are not suffi ciently specifi c to be diagnostic and must be confi rmed by culture.…”

Section: Histopathology and Cytologymentioning

confidence: 99%

Coccidioidal meningitis: Update on epidemiology, clinical features, diagnosis, and management

Blair

2009

Curr Infect Dis Rep

View full text Add to dashboard Cite

Coccidioidomycosis is a fungal infection endemic to geographically restricted areas of the southwestern United States, and its incidence is increasing within endemic areas. Coccidioidal meningitis, an infrequent but very severe form of coccidioidomycosis, is associated with significant mortality and morbidity. The diagnosis depends on the demonstration of coccidioidal antibody or positive culture, histopathology, or cytology in the presence of typical abnormalities of the cerebrospinal fluid. Central nervous system complications of this infection may include hydrocephalus, vasculitis, infarctions, or parenchymal abscesses. Many patients with coccidioidal meningitis can achieve remission of infection following treatment with triazole antifungal agents. However, first-line therapy with high-dose oral fluconazole is associated with a high incidence of relapse after drug discontinuation. This article summarizes the pathogenesis, epidemiology, clinical manifestations, diagnostic studies, and treatment of coccidioidal meningitis, and highlights new information regarding this devastating infection.

show abstract

Coccidioides immitis meningitis with arthroconidia in cerebrospinal fluid: Reportof the first case and review of the arthroconidia literature

Cited by 21 publications

References 13 publications

Innovation of the Parasitic Cycle of Coccidioides spp.

Innovation of the Parasitic Cycle of Coccidioides spp.

Serology of coccidioidomycosis

Coccidioidal meningitis: Update on epidemiology, clinical features, diagnosis, and management

Contact Info

Product

Resources

About