Coccidioidal Granuloma

Chipman, Ernest Dwight

doi:10.1001/archderm.1930.01440080099012

Cited by 11 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There have been numerous experimental studies of primary cutaneous coccidioidomycosis in animals: the dog and the rabbit (Rixford, 1894a, b;Ophuls, 1905); the guinea pig (Davis, 1924;Chipman and Templeton, 1930;Guy and Jacobs, 1927); and mice (Pappagianis et al, 1959). In these studies, systemic dissemination was extremely rare.…”

mentioning

confidence: 99%

Experimental Viable Vaccine Against Pulmonary Coccidioidomycosis in Monkeys

1963

View full text Add to dashboard Cite

Macaca mulatta) vaccinated by subcutaneous injection in the forearm with from 10 to 108 viable Coccidioides immitis arthrospores were protected against respiratory challenge with approximately 7000 viable arthrospores administered 6 months after vaccination. Protection was evident from: the healthy appearance throughout 4 months after respiratory challenge; negative chest X rays at 15, 30, 60, and 120 days; and only very minor histopathological pulmonary changes on autopsy at 120 days, with negative lung cultures in 80% of the animals. This was in striking contrast to the outward clinical appearance of control monkeys that were unvaccinated or had received nonviable arthrospore vaccines. These monkeys showed severe disease (loss of weight, accelerated respiration, severe coughing, general debilitation), positive X rays, massive pulmonary destruction, positive lung cultures, and death of five of nine animals. The appearance of spherules (very few in number, accompanied by very minor pathological changes) in the lungs of some of the "dissemination controls" (subcutaneous viable vaccination without respiratory challenge) indicated possible dissemination from the primary cutaneous infection, although oral transmission from the cutaneous lesions could not be ruled out.

show abstract

mentioning

confidence: 99%

Experimental Viable Vaccine Against Pulmonary Coccidioidomycosis in Monkeys

1963

View full text Add to dashboard Cite

show abstract

“…Of interest were the calcified deposits on the frontal bones, an exostosis of the hard palate and calcium-like deposits in the sloughs from the mouth, all 1 of which suggested disturbance of the calcium metab¬ olism. The appearance in the blood of granulocytes on the fifth day following the administration of calcium gluconate suggests that this agent may be of therapeutic value.…”

Section: Report Of Casementioning

confidence: 99%