Cocaine-Induced Release of Corticosterone Mediates Differential Effects on T-Helper1 and T-Helper2 Cell Responses

Kump, Denton F.; Stanulis, Eric D.; Holsapple, Michael P.; Conrad, Daniel H.; Rosecrans, John A.

doi:10.1007/978-1-4615-5347-2_21

Cited by 10 publications

(5 citation statements)

References 9 publications

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“…However, little has been studied in terms of how drugs of abuse impact hematopoiesis. There is a single clinical report of severe aplastic anemia following extreme chronic 3,4-methylenedioxy-N-methylamphetamine (MDMA) use 18 and there are a handful of reports addressing the effects of marijuana on blood cell development 19 . Reports of hematopoietic disregulation due to cocaine use are few but do support the hypothesis that cocaine disrupts normal blood cell homeostasis 20 21 .…”

mentioning

confidence: 99%

Cocaine exposure impairs multilineage hematopoiesis of human hematopoietic progenitor cells mediated by the sigma-1 receptor

Nixon

Schwartz

Dixit

et al. 2015

Sci Rep

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Prenatal exposure to cocaine is a significant source of fetal and neonatal developmental defects. While cocaine associated neurological and cardiac pathologies are well-documented, it is apparent that cocaine use has far more diverse physiological effects. It is known that in some cell types, the sigma-1 receptor mediates many of cocaine's cellular effects. Here we present a novel and concise investigation into the mechanism that underlies cocaine associated hematopoietic pathology. Indeed, this is the first examination of the effects of cocaine on hematopoiesis. We show that cocaine impairs multilineage hematopoiesis from human progenitors from multiple donors and tissue types. We go on to present the first demonstration of the expression of the sigma-1 receptor in human CD34 + human hematopoietic stem/progenitor cells. Furthermore, we demonstrate that these cocaine-induced hematopoietic defects can be reversed through sigma-1 receptor blockade.

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mentioning

confidence: 99%

Cocaine exposure impairs multilineage hematopoiesis of human hematopoietic progenitor cells mediated by the sigma-1 receptor

Nixon

Schwartz

Dixit

et al. 2015

Sci Rep

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“…We were also interested in the response of stress hormones such as corticosterone with or without preoperative fasting stress. Corticosterone was known to suppress cell mediated immunity as well as inflammatory cytokine responses [24][25][26][27], thereby impairing the ability to remove intravascular malignant cells [28,29]. In our study, preoperative serum corticosterone level was significantly increased in the fasting group compared to the control group.…”

Section: Discussionmentioning

confidence: 50%

The Effect of Starvation on Blood Stream Cancer Cell Metastasis to the Liver in Rat after Laparotomy

et al. 2013

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“…In conjunction with this information, cocaine has been implicated in dysregulation of the Th1/Th2 cytokine balance and in driving the immune response towards a Th2-type response. 13,38,39 Preferential Th1- and Th2-type responses account for several immunopathological disorders, such as allergic responses and fetal transplantation tolerance. During HIV-1 infection in particular, the imbalance between Th1/Th2 cytokines was significant, especially given that the bias towards a Th2-type response and an inhibition of Th1-type response has been associated with the immune system failing to control HIV-1 infection, leading to progression of the infection towards AIDS.…”

Section: Discussionmentioning

confidence: 99%

Cocaine Alters Cytokine Profiles in HIV-1–Infected African American Individuals in the DrexelMed HIV/AIDS Genetic Analysis Cohort

Parikh

Dampier

Feng

et al. 2014

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Background This study evaluated the relationship between illicit drug use and HIV-1 disease severity in HIV-1-infected patients enrolled in the DrexelMed HIV/AIDS Genetic Analysis Cohort. Since, cocaine is known to have immunomodulatory effects, the cytokine profiles of preferential nonusers, cocaine users, and multidrug users were analyzed to understand the effects of cocaine on cytokine modulation and HIV-1 disease severity. Methods Patients within the cohort were assessed approximately every 6 months for HIV-1 clinical markers and for history of illicit drug, alcohol, and tobacco use. The Luminex human cytokine 30-plex panel was used for cytokine quantitation. Analysis was performed using a newly developed biostatistical model. Results Substance abuse was common within the cohort. Utilizing the drug screens at the time of each visit, the subjects in the cohort were categorized as preferential nonusers, cocaine users, or multidrug users. The overall health of the nonuser population was better than that of the cocaine users, with peak and current viral loads in nonusers substantially lower than those in cocaine and multidrug users. Among the 30 cytokines investigated, differential levels were established within the 3 populations. The T-helper 2 cytokines, interleukin-4 and -10, known to play a critical role during HIV-1 infection, were positively associated with increasing cocaine use. Clinical parameters such as latest viral load, CD4+ T-cell counts, and CD4:CD8 ratio were also significantly associated with cocaine use, depending on the statistical model used. Conclusions Based on these assessments, cocaine use appears to be associated with more severe HIV-1 disease.

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Cocaine-Induced Release of Corticosterone Mediates Differential Effects on T-Helper1 and T-Helper2 Cell Responses

Cited by 10 publications

References 9 publications

Cocaine exposure impairs multilineage hematopoiesis of human hematopoietic progenitor cells mediated by the sigma-1 receptor

Cocaine exposure impairs multilineage hematopoiesis of human hematopoietic progenitor cells mediated by the sigma-1 receptor

The Effect of Starvation on Blood Stream Cancer Cell Metastasis to the Liver in Rat after Laparotomy

Cocaine Alters Cytokine Profiles in HIV-1–Infected African American Individuals in the DrexelMed HIV/AIDS Genetic Analysis Cohort

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