“…Interestingly, the systemic pathophysiology of CUD includes several metabolic alterations. For instance, chronic cocaine use is associated with increased prevalence of hypertension (Brecklin, Gopaniuk-Folga, Kravetz et al, 1998) and myocardial infarction (Behar, Lindsay & McEwan, 2009), which are hallmark features of metabolic syndrome (Virmani, Binienda, Ali et al, 2007). In addition, we and others have found elevated blood levels of adiponectin, a protein hormone that modulates a number of metabolic processes such as glucose uptake and fatty acid oxidation, among individuals with CUD during early abstinence (Levandowski, Viola, Tractenberg et al, 2013;You, Wang, Gardner et al, 2019).…”