Cocaine-induced liver injury in mice is mediated by nitric oxide and reactive oxygen species

Aoki, Kimiko; Ohmori, Mitsuyo; Takimoto, Masafumi; Ota, Hidekazu; Yoshida, Takemi

doi:10.1016/s0014-2999(97)01230-2

Cited by 56 publications

(43 citation statements)

References 21 publications

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“…40 The beneficial effects of AG in various experimental models of inflammation have also been reported. 41 Recently, Mansour et al 36 reported that AG protects against nephrotoxicity induced by cisplatin (CDDP) in rats.…”

Section: Discussionmentioning

confidence: 94%

Aminoguanidine ameliorates radiation-induced oxidative lung damage in rats

Eroğlu¹,

Yildiz²,

Saraymen³

et al. 2008

CIM

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Clin Invest Med 2008; 31 (4): E182-E188.Abstract Purpose: To investigate the possible protective effects of aminoguanidine (AG ) on lung damage in whole body irradiated rats. Methods: To evaluate the biological damage of radiation on rat lung tissue, lipid peroxidation products were measured using biochemical parameters. Thirty Wistar albino rats were divided into three subgroups: control (C) , irradiation alone (RT), and RT + AG combined. After sacrificing the rats, antioxidant enzymes catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) activities and malondiadehyde (MDA), nitric oxide (NO) levels were evaluated in lung tissue. Results: Administration of AG resulted in an increase in the activities of CAT, SOD and GSHPx in the lungs. All were reduced after radiatio. In addition, AG administration resulted in a decrease in both NO and MDA levels in lung compared with the irradiated group. Conclusion: Amnoguanidine increased the endogenous antioxidant defence mechanism in rats and protected the animals from radiation-induced lung toxicity. Moreover, AG may protect against ionizing radiation-induced lung damage because of its antioxidant effect.Radiation therapy (RT) is a crucial component of application for many thoracic malignancies. Radiationinduced lung toxicity remains a major factor that limits the ability to escalate radiation doses in the application of thoracic tumours. RT-related pulmonary symptoms occur in up to 30% of patients irradiated for lung cancer, breast cancer, lymphoma, or thymoma. Pulmonary toxicity from thoracic irradiation is also an important problem in other settings, including combined modality treatment of Hodgkin's disease and esophageal cancer, and bone marrow transplantation with total body irradiation. 1 Ionizing radiation is a well-established carcinogen due to the resulting oxidative damage, and the molecule most often reported to be damaged by this physical agent is DNA. 2 Aproximately 60-70% of cellular DNA damage produced by ionizing radiation is caused by OH, formed from the radiolysis of water. 3 Besides DNA, lipids and proteins are also attacked by free radicals induced by ionizing radiation. 4 Lipid peroxidation is believed to be an important cause of destruction and damage to cell membranes and has been suggested to be a contributing factor to the development of oxygen radicals-mediated tissue damage. 5 Oxidative stress occurs when there is excessive free radical production and/or low antioxidant defence, and results in chemical alterations of biomolecules causing structural and functional ORIGINAL RESEARCH

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Section: Discussionmentioning

confidence: 94%

Aminoguanidine ameliorates radiation-induced oxidative lung damage in rats

Eroğlu¹,

Yildiz²,

Saraymen³

et al. 2008

CIM

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“…These models include various forms of liver injury, i.e., ones induced by ionizing radiation (Srivastava and Kale, 1999;Srivastava et al, 2002), ethanol (Oei et al, 1982;Lieber, 1997;Kono et al, 2000;Zima et al, 2001), cocaine (Aoki et al, 1997), thioacetamide (Ali et al, 2001), acetaminophen (Knight et al, 2001), and aluminum (Moumen et al, 2001). In the case of ethanol, aluminum, and radiation, enhancement of hepatic XO levels and/or spillage of XO into the circulation were detected (Oei et al, 1982;Zima et al, 1993;Moumen et al, 2001;Srivastava et al, 2002).…”

Section: G Xanthine Oxidase and Various Forms Of Toxic Organ Injurymentioning

confidence: 99%

Therapeutic Effects of Xanthine Oxidase Inhibitors: Renaissance Half a Century after the Discovery of Allopurinol

2006

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“…It has been reported that NO is produced by constitutive NOS isoforms present in Kupffer cells [10] and guanidine can scavenge part of the peroxynitrite produced by residual iNOS activity or from NO produced by constitutive NOS isoforms [26]. In a previous study it has been reported that local NO production plays a harmful role in cocaine-induced hepatotoxicity [27] and a similar mechanism might operate in case of allyl alcohol-induced hepatotoxicity. Furthermore, in an experimental model of liver cirrhosis AG was shown to exert its beneficial effects by the inhibition of NO production [14].…”

Section: Discussionmentioning

confidence: 98%

Beneficial effect of nitric oxide synthase inhibitor on hepatotoxicity induced by allyl alcohol

Alam

Nagi

Al‐Shabanah

et al. 2001

J Biochem & Molecular Tox

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The effect of aminoguanidine (a selective inhibitor of inducible nitric oxide synthase) on allyl alcohol-induced liver injury was assessed by the measurement of serum ALT and AST activities and histopathological examination. When aminoguanidine (50-300 mg/kg, i.p.) was administered to mice 30 min before a toxic dose of allyl alcohol (75 microL/kg, i.p.), significant changes related to liver injury were observed. In the presence of aminoguanidine the level of ALT and AST enzymes were significantly decreased. All symptoms of liver necrosis produced by allyl alcohol toxicity almost completely disappeared when animals were pretreated with aminoguanidine at 300 mg/kg. Depletion of hepatic glutathione as a consequence of allyl alcohol metabolism was minimal in mice pretreated with aminoguanidine at 300 mg/kg. It was found that the inhibition of toxicity was not due to alteration in allyl alcohol metabolism since aminoguanidine did not effect alcohol dehydrogenase activity both in vivo and in vitro.

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Cocaine-induced liver injury in mice is mediated by nitric oxide and reactive oxygen species

Cited by 56 publications

References 21 publications

Aminoguanidine ameliorates radiation-induced oxidative lung damage in rats

Aminoguanidine ameliorates radiation-induced oxidative lung damage in rats

Therapeutic Effects of Xanthine Oxidase Inhibitors: Renaissance Half a Century after the Discovery of Allopurinol

Beneficial effect of nitric oxide synthase inhibitor on hepatotoxicity induced by allyl alcohol

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