Cocaine-Induced Full-Thickness Tissue Necrosis

Abstract

DISCLOSUREThe authors have no financial interest to declare in relation to the content of this article. Fig. 1. A 60-year-old woman who underwent resection of a liposarcoma on the right shoulder. (Left) The location of the perforating branches of the tenth intercostal artery in the lateral part of the latissimus dorsi muscle was detected by color Doppler sonography. The divided latissimus dorsi flap was designed to include the perforator in the distal flap. (Right) Three months after primary closure of the donor site.REFERENCES 1. Zhang YX, Messmer C, Pang FK, et al. A novel design of the multilobed latissimus dorsi myocutaneous flap to achieve primary donor-site closure in the reconstruction of large defects. Plast Reconstr Surg. 2013;131:752e-758e. 2. Sawaizumi M, Maruyama Y. Sliding shape-designed latissimus dorsi flap. Ann Plast Surg. 1997;38:41-45.

Bizarre Cutaneous Ulcers due to Self-Administered Intravenous Dexketoprofen Trometamol

“…Necrotic skin lesions and ulcer formation may also be seen following extravasation of cytotoxic drugs 4 and in intravenous drug addicts. [5][6][7] However, using a search of Pubmed, extensive cutaneous ulcers in relation to self-administered intravenous dexketoprofen trometamol use has not been identified before although cutaneous ulcers have been described in association with several opioids. 8,9 To our knowledge, this is the first reported case of bizarre and widespread cutaneous ulcers following self-administered intravenous dexketoprofen trometamol.…”

Antineutrophil cytoplasmic antibodies negative levamisole‐induced leukocytoclastic vasculitis: a presumed case and literature review

“…Levamisole is an immunomodulatory chemical originally used to treat colon adenocarcinoma and nephrotic syndrome in children . However, it was withdrawn from the United States market in 2000 by the United States Food and Drug Administration and the Canadian market in 2003 due to serious side effects including neutropenia, agranulocytosis, autoimmune antibodies, hepatosplenomegaly, arthralgia, retiform purpura, and full thickness cutaneous necrosis .…”

“…Levamisole is an immunomodulatory chemical originally used to treat colon adenocarcinoma and nephrotic syndrome in children. [1][2][3][4] However, it was withdrawn from the United States market in 2000 by the United States Food and Drug Administration and the Canadian market in 2003 due to serious side effects including neutropenia, agranulocytosis, autoimmune antibodies, hepatosplenomegaly, arthralgia, retiform purpura, and full thickness cutaneous necrosis. [2][3][4][5][6] Levamisole is also used as a veterinary antihelminthic; however, it has been repurposed as an agent to cut cocaine due to its low cost, similarity in gross appearance, and ability to bypass rudimentary street purity tests.…”