Cocaine-induced brain activation detected by dynamic manganese-enhanced magnetic resonance imaging (MEMRI)

Lu, Hanbing; Xi, Zheng‐Xiong; Gitajn, Leah; Rea, William; Yang, Yihong; Stein, Elliot A.

doi:10.1073/pnas.0606983104

Cited by 103 publications

(116 citation statements)

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“…This is a logical approach for dynamic MEMRI studies, comparing signal differences over a single imaging session (Lu et al, 2007), or for MEMRI studies of Mn transport along axonal tracts after focal brain injection (Cross et al, 2004). These previous methods employed Z-statistical mapping, using random field theory to constrain the Type I error rate (Friston et al, 1990(Friston et al, , 1991Worsley et al, 1992), as opposed to our direct computation of pvalue maps from tstatistics.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to low resolution BOLD-fMRI, MEMRI lends itself to study activity patterns in the brains of small animals at high resolution. In addition to our previous auditory studies (Yu et al, 2005;Yu et al, 2007), MEMRI has also been applied to study odor induced activity in the olfactory bulb (Pautler et al, 1998;Chuang et al, 2006), to examine light adaptation in retinal neurons (Berkowitz et al, 2006), to map cocaine-induced neuronal activation (Lu et al, 2007), and to detect hypothalamic activity (Morita et al, 2003;Chaudhri et al, 2006;Kuo et al, 2006) and ischemia-induced excitotoxicity (Aoki et al, 2003). Furthermore, MEMRI has been validated by correlation with BOLD and CBF (cerebral blood flow) functional maps in the somatosensory cortex of rats (Duong et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

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Statistical mapping of sound-evoked activity in the mouse auditory midbrain using Mn-enhanced MRI

Zou

Babb

et al. 2008

NeuroImage

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Manganese-enhanced MRI (MEMRI) has been developed to image brain activity in small animals, including normal and genetically modified mice. Here, we report the use of a MEMRI-based statistical parametric mapping method to analyze sound-evoked activity in the mouse auditory midbrain, the inferior colliculus (IC). Acoustic stimuli with defined frequency and amplitude components were shown to activate and enhance neuronal ensembles in the IC. These IC activity patterns were analyzed quantitatively using voxel-based statistical comparisons between groups of mice with or without sound stimulation. Repetitive 40-kHz pure tone stimulation significantly enhanced ventral IC regions, which was confirmed in the statistical maps showing active regions whose volumes increased in direct proportion to the amplitude of the sound stimuli (65dB, 77dB, and 89dB peak sound pressure level). The peak values of the activity-dependent MEMRI signal enhancement also increased from 7 to 20% for the sound amplitudes employed. These results demonstrate that MEMRI statistical mapping can be used to analyze both the 3D spatial patterns and the magnitude of activity evoked by sound stimuli carrying different energy. This represents a significant advance in the development of MEMRI for quantitative and unbiased analysis of brain function in the deep brain nuclei of mice.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Statistical mapping of sound-evoked activity in the mouse auditory midbrain using Mn-enhanced MRI

Zou

Babb

et al. 2008

NeuroImage

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“…Data preprocessing included slice-timing correction, linear and quadratic trend removal, and spatial smoothing with a Gaussian kernel (full width at half maximum = 0.6 mm). Images from individual animals were then coregistered onto a common 3D space aligned with a rat stereotaxic atlas using an approach previously described (54,55). Analyses were performed within the AFNI framework (56).…”

Section: Methodsmentioning

confidence: 99%

Rat brains also have a default mode network

Zou

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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The default mode network (DMN) in humans has been suggested to support a variety of cognitive functions and has been implicated in an array of neuropsychological disorders. However, its function (s) remains poorly understood. We show that rats possess a DMN that is broadly similar to the DMNs of nonhuman primates and humans. Our data suggest that, despite the distinct evolutionary paths between rodent and primate brain, a well-organized, intrinsically coherent DMN appears to be a fundamental feature in the mammalian brain whose primary functions might be to integrate multimodal sensory and affective information to guide behavior in anticipation of changing environmental contingencies.functional MRI | resting state | intrinsic activity | connectivity | spontaneous fluctuation I n the absence of an immediate need for goal-directed attention to the surrounding environment, our minds wander from recollection of past happenings to imagination of future events. Neuroimaging studies have consistently identified a set of interconnected brain areas that becomes less active during attentiondemanding cognitive tasks (1). This so-called default mode network (DMN) is posited to play a fundamental role in brain organization and supports a variety of self-referential functions such as understanding others' mental state, recollection and imagination (2), conceptual processing (3), and even in the sustenance of conscious awareness (4). Many of these functions have been considered to be unique to humans. Intriguingly, similar coherent structures have been shown to exist in anesthetized macaque monkeys and chimpanzees (5, 6). Furthermore, the functions of the default network are disrupted in such neuropsychological disorders as schizophrenia, Alzheimer's disease, and autism (7-9), underscoring the clear and critical need for further investigating the neurobiological basis of DMN using animal models.The evolutionary clade of rodents is about 35 million years earlier than that of old world monkeys and about 60 million years earlier than humans (10). Although many of the structures and functions of subcortical nuclei are conserved across these three species, the neocortex, in particular the "association" cortex, has extensively expanded in the primate as a result of evolutionary pressure, which is considered to be crucial in the development of higher cognitive and behavioral functions (10, 11). On the other hand, such structures as cingulate cortex, prefrontal cortex, and hippocampal formation, all of which are critical elements of the DMN, are also present in rodents (11). Given the distant evolutionary paths between rodent and primate brain, an intriguing question arises: Does the rat possess a similar DMN? Such a network, once demonstrated, would not only suggest that an operational DMN is a common feature in the mammalian brain, perhaps induced via parallel evolution as a result of natural selection, it would also offer a novel platform to explore the physiological basis and behavioral significance of the DMN. Such a demonstratio...

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“…However, a major problem beyond a certain level of Mn 2+ is its cellular toxicity, in particular its well-known ability to cause movement disorders such as Parkinson's disease [17][18][19]. Concomitant to improvements in the sensitivity of MeMRI techniques, it is equally important to use lower concentrations of Mn 2+ and develop new ways to administer the contrast agent directly into the target organ.…”

Section: Introductionmentioning

confidence: 99%

New Method of Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) for Rat Brain Research

et al. 2012

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Manganese (Mn 2+ )-enhanced MRI (MEMRI) is known to provide insight into functional and anatomical biology. However, this method, which uses Mn 2+ as a MRI-detectable contrast agent, has drawbacks such as the toxicity to cells beyond a certain level of Mn 2+ . In this study, we attempt to determine a new method of ICV administration, the optimal concentration of administered Mn 2+ and the optimal MEMRI acquisition time following administration. Male Sprague-Dawley rats were used in the following experimental sessions: (1) intracerebroventricular (ICV) cannula implantation in the region of the cisterna magna, (2) serial dilution of MnCl 2 (20-80 mM), (3) ICV administration of MnCl 2 through the cannula, and (4) T 1 -weighted MRI measurements. We confirmed that cannula implantation in the region of the cisterna magna was a new ICV injection method for the administration of a contrast agent. The optimal concentration for MEMRI was 20/50 mM/µl of MnCl 2 . The MEMRI data acquired at different time points indicate that most signal enhancement is maintained during 14-48 h after contrast agent injection, and 24 h was the optimal time to acquire images of the rat brain. The present study offers optimized parameters for contrast agent injection that would be a good basis for studies using MEMRI to research the rat brain.

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Cocaine-induced brain activation detected by dynamic manganese-enhanced magnetic resonance imaging (MEMRI)

Cited by 103 publications

References 50 publications

Statistical mapping of sound-evoked activity in the mouse auditory midbrain using Mn-enhanced MRI

Statistical mapping of sound-evoked activity in the mouse auditory midbrain using Mn-enhanced MRI

Rat brains also have a default mode network

New Method of Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) for Rat Brain Research

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