Cocaine-Induced Acute Pancreatitis

Strzepka, Jessica; Tian, Frances; Nassani, Najib; Garcia-Bedoya, Olga; Yazıcı, Cemal

doi:10.14309/crj.0000000000000487

Cited by 5 publications

(11 citation statements)

References 16 publications

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“…Acute pancreatitis secondary to cocaine use has been described in a total of 7 case reports only (level of clinical evidence: IV), dating from 2005 to 2020 [7][8][9][10][11][12][13]. Cocaineinduced pancreatitis showed a clear male predominance, as all 7 patients were male.…”

Section: Resultsmentioning

confidence: 99%

“…Permanent cessation of cocaine is imperative in terms of treatment. Conservative management, using adequate pain control, goal-directed intravenous fluid resuscitation, and correction of electrolyte and metabolic problems, is instrumental in the recovery of most patients in 3-7 days [8,11,12]. In addition to acute pancreatitis, patients may also rarely develop concurrent gastric ulceration and bleeding, requiring prompt hemostasis [9].…”

Section: Discussionmentioning

confidence: 99%

“…In addition to acute pancreatitis, patients may also rarely develop concurrent gastric ulceration and bleeding, requiring prompt hemostasis [9]. In severe cases of cocaine-related acute pancreatitis, intensive care unit admission might be required due to associated complications and organ failure [9,10,12]. The reported systemic complications include incomplete thrombotic microangiopathy, vasculitis, pauciimmune necrotizing glomerulonephritis, and multiorgan involvement [9,10,12].…”

Section: Discussionmentioning

confidence: 99%

“…In severe cases of cocaine-related acute pancreatitis, intensive care unit admission might be required due to associated complications and organ failure [9,10,12]. The reported systemic complications include incomplete thrombotic microangiopathy, vasculitis, pauciimmune necrotizing glomerulonephritis, and multiorgan involvement [9,10,12]. Extensive management is warranted depending on the complications in such patients.…”

Section: Discussionmentioning

confidence: 99%

“…However, cocaine-associated acute pancreatitis is an extremely rare entity. To our research, only 7 such cases have been reported in the English-language literature thus far [7][8][9][10][11][12][13]. Clinical features, serum levels of pancreatic enzymes, and consistent radiological findings, in combination with exclusion of common causes of pancreatitis are pivotal for establishing the diagnosis [14].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Acute pancreatitis secondary to cocaine use: a case-based systematic literature review

Goraya

Malik

Inayat

et al. 2021

Clin J Gastroenterol

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Cocaine use continues to be an important global public health problem. As the use of cocaine remains pervasive so have a myriad of adverse events associated with this drug. These deleterious effects are well-studied, but gastrointestinal complications remain esoteric and the existing clinical evidence is scarce. Ischemia of the esophagus and small bowel, perforation, peptic ulceration, gastrointestinal bleeding, and ischemic colitis are among the reported complications. In specific, acute pancreatitis secondary to cocaine use is an exceedingly rare clinicopathologic entity. To date, only 7 cases of this condition have been reported in the English-language literature. We hereby delineate a rare case of a 29-year-old female who developed her first episode of cocaine-associated pancreatitis. The diagnosis was made based on a standard battery of investigations and meticulous exclusion of common etiologies of acute pancreatitis. To our knowledge, this case represents the first report of re-occurrence of acute pancreatitis upon subsequent crack cocaine insufflation, adding a higher level of evidence to a fallible association. We also present a systematic review of the existing literature on acute pancreatitis following cocaine use. An updated knowledge regarding this rare association is of paramount importance for early diagnosis and astute management.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Acute pancreatitis secondary to cocaine use: a case-based systematic literature review

Goraya

Malik

Inayat

et al. 2021

Clin J Gastroenterol

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Cocaine Gut: A Rare Case of Cocaine-Induced Esophageal, Gastric, and Small Bowel Necrosis

Bathobakae,

Ozgur,

Bashir

et al. 2024

Journal of Investigative Medicine High Impact Case Reports

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Cocaine is an indirect-acting sympathomimetic drug that inhibits norepinephrine and dopamine reuptake in the adrenergic presynaptic cleft. Cocaine use has been associated with strokes, angina, arrhythmias, and agitation. Data on gastrointestinal complications such as mesenteric ischemia, bowel necrosis, ulceration, and perforation are scarce. Here, we present a rare case of cocaine-induced esophageal, gastric, and small bowel necrosis that contributes to the limited literature on this subject. Diagnosis of cocaine-induced gastrointestinal complications involves a combination of imaging studies, laboratory assessments, and histopathological examinations. Timely surgical resection, supported by intravenous fluids, antibiotics, and pain management, is the mainstay of treatment. The prognosis varies but is significantly influenced by the promptness and effectiveness of the intervention, underscoring the importance of vigilant clinical care in such cases.

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Pancreatitis aguda asociada a cocaína, una complicación inusual. Serie de casos

Vásquez¹,

Mejía²,

Mejía

2023

MedUPB

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La cocaína es una de las sustancias ilegales más consumidas y Colombia no es la excepción. Dentro de las sustancias ilegales es la segunda más consumida después del cannabis. Por su mecanismo mismo de acción, que produce aumento de aminas biógenas, se han asociado con la cocaína diferentes riesgos, tanto agudos como crónicos, y dentro de sus complicaciones se han descrito cambios comportamentales, compromiso cardiovascular y neurológico. La coingesta de cocaína y alcohol da lugar a un metabolito conocido como cocaetileno, que lleva a complicaciones cardiovasculares. Poco se ha descrito sobre el riesgo de la cocaína o la coingesta cocaína y alcohol, como un factor sumatorio, para la pancreatitis. Reportamos tres pacientes jóvenes consumidores del alcaloide que desarrollaron pancreatitis aguda, dos de ellos murieron. El objetivo de este reporte es sensibilizar a los trabajadores de la salud sobre otro riesgo para considerar en los pacientes consumidores de cocaína.

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Cocaine-Induced Acute Pancreatitis

Cited by 5 publications

References 16 publications

Acute pancreatitis secondary to cocaine use: a case-based systematic literature review

Acute pancreatitis secondary to cocaine use: a case-based systematic literature review

Cocaine Gut: A Rare Case of Cocaine-Induced Esophageal, Gastric, and Small Bowel Necrosis

Pancreatitis aguda asociada a cocaína, una complicación inusual. Serie de casos

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