Cocaine-induced activation of striatal neurons during focused stereotypy in rats

White, Ilsun M.; Doubles, Lisa; Rebec, George V.

doi:10.1016/s0006-8993(98)00905-6

Cited by 27 publications

(20 citation statements)

References 28 publications

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“…The second explanation for the observed effect is that the same neurons that are normally activated by the tasks may have been activated to a greater extent in the presence of amphetamine. This is consistent with the observations in laboratory animals that both amphetamine and cocaine appear to increase the gain, or signal-to-noise ratio, by increasing the electrophysiological activity of individual neurons associated with motor function in rodents (Haracz et al 1993;Rebec et al 1997;White et al 1998). It is not possible to separate these two actions from the present results, and the two actions are not mutually exclusive.…”

Section: Discussionsupporting

confidence: 90%

An fMRI Study of the Effect of Amphetamine on Brain Activity,

Uftring

Wachtel

Chu

et al. 2001

Neuropsychopharmacology

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Section: Discussionsupporting

confidence: 90%

An fMRI Study of the Effect of Amphetamine on Brain Activity,

Uftring

Wachtel

Chu

et al. 2001

Neuropsychopharmacology

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“…The lack of similar effects with the high-dose range may be due to the neurotoxic effects of high doses of cocaine, which fall into our 20-40 mg/kg dosage range (Stalnaker, 2007a). This interpretation is consistent with the ability of cocaine to enhance activation of dorsal striatum (White et al, 1998), which mediates stimulus-response learning (Takahashi et al, 2007), and induce neurotoxicity to the orbitofrontal cortex which impairs associative learning (Stalnaker et al, 2007a). Thus, our dose range of 10-20 mg/kg may have been sufficient to generate greater plasticity in associative structures while still low enough to not cause functional damage in frontal cortex.…”

Section: Discussionsupporting

confidence: 76%

Cocaine withdrawal alters the reward omission effect and enhances traits of negative urgency in rats across multiple days of testing

Barker

Rebec

2016

Drug and Alcohol Dependence

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Background The personality trait of negative urgency, characterized as behaving rashly when emotionally perturbed, is gaining attention as an indicator for susceptibility to problematic substance use. How this trait is influenced by exposure to drugs of abuse is still unclear. Using an animal model of binge cocaine consumption, we tested this relationship in a reward-omission task across multiple days. Methods Adult, male, Sprague-Dawley rats received seven daily (ip) injections of saline, cocaine (10-20 mg/kg), or cocaine (20-40 mg/kg). Cocaine doses increased linearly each day from the lower to the higher dose. A separate group received RTI-113 (3.0 mg/kg), a selective dopamine transporter inhibitor, for 7 days. Fifteen days after their final injection, rats were trained on a reward-omission task with an operant component to earn further rewards. Results Previous exposure to cocaine resulted in dose-dependent increases in negative urgency in separate behavioral variables across days of testing. The lower dose range increased negative urgency on the dimension of decreased reaction time to press a lever, while the higher dose range increased the rate of increase in lever presses made per trial. Rats receiving RTI-113 did not resemble either cocaine group and instead showed a decrease in lever pressing across days. Conclusions Our results indicate that previous binge cocaine consumption enhances behavioral markers of negative urgency in a dose-dependent, time-sensitive manner on discrete behavioral dimensions. The results with RTI-113 suggest the relationship between cocaine exposure and negative urgency is unlikely to be explained solely by inhibition of dopamine reuptake.

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“…This drug-induced effect of intravenous cocaine is in accord with the involvement of the dorsal striatum in reward and addiction 57 . Importantly, striatal DA release has been shown to differentially activate subpopulations of striatal neurons 50, 58 , and cocaine is well known to elicit neural activity in the region 59, 60 . Overall, the data demonstrate that glucose influx follows electrically stimulated and pharmacologically evoked DA release, likely in response to metabolic demand within the dorsal striatum.…”

Section: Resultsmentioning

confidence: 99%

Simultaneous Voltammetric Measurements of Glucose and Dopamine Demonstrate the Coupling of Glucose Availability with Increased Metabolic Demand in the Rat Striatum

Smith

Lee

Dausch

et al. 2017

ACS Chem. Neurosci.

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Cerebral blood flow ensures delivery of nutrients, such as glucose, to brain sites with increased metabolic demand. However, little is known about rapid glucose dynamics at discrete locations during neuronal activation in vivo. Acute exposure to many substances of abuse elicits dopamine release and neuronal activation in the striatum; however, the concomitant changes in striatal glucose remain largely unknown. Recent developments have combined fast-scan cyclic voltammetry with glucose oxidase enzyme modified carbon-fiber microelectrodes to enable the measurement of glucose dynamics with subsecond temporal resolution in the mammalian brain. This work evaluates several waveforms to enable the first simultaneous detection of endogenous glucose and dopamine at single recording sites. These molecules, one electroactive and one non-electroactive, were found to fluctuate in the dorsal striatum in response to electrical stimulation of the midbrain and systemic infusion of cocaine/ raclopride. The data reveal the second-by-second dynamics of these species in a striatal microenvironment, and directly demonstrate the coupling of glucose availability with increased metabolic demand. This work provides a foundation that will enable detailed investigation of local mechanisms that regulate the coupling of cerebral blood flow with metabolic demand under normal conditions, and in animal studies of drug abuse and addiction.

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Cocaine-induced activation of striatal neurons during focused stereotypy in rats

Cited by 27 publications

References 28 publications

An fMRI Study of the Effect of Amphetamine on Brain Activity,

An fMRI Study of the Effect of Amphetamine on Brain Activity,

Cocaine withdrawal alters the reward omission effect and enhances traits of negative urgency in rats across multiple days of testing

Simultaneous Voltammetric Measurements of Glucose and Dopamine Demonstrate the Coupling of Glucose Availability with Increased Metabolic Demand in the Rat Striatum

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