Cocaine increases human immunodeficiency virus type 1 neuroinvasion through remodeling brain microvascular endothelial cells

Fiala, Milan; Eshleman, Amy J.; Cashman, John R.; Lin, Jun; Lossinsky, A. S.; Suarez, Vannina; Yang, Wendy; Zhang, Jun; Popik, Waldemar; Singer, Elyse J.; Chiappelli, Francesco; Carro, Eva; Weinand, Martin E.; Witte, Marlys H.; Arthos, James

doi:10.1080/13550280590952835

Cited by 77 publications

(97 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Menos frecuentes son la hipotensión arterial y el shock (signos de extrema gravedad), el aneurisma aórtico agudo, las bradicardias con síndromes de QT largo y disección aórtica. Incrementa el riesgo de IAM y de muerte repentina siendo el fallo cardíaco la causa de más frecuente muerte asociada al consumo (13).…”

Section: Técnicas De Neuroimagen Estudios Neuroendocrinos: Defectos Funclassified

“…Sobre el SNC, y aunque la mayoría de los pacientes sean remitidos por inquietud o agitación (13), causa midriasis, mioclonias, convulsiones y coma de forma aguda, y deterioro cognitivo leve pero duradero y limitación de la plasticidad neuronal de forma crónica. También aumenta el riesgo de traumatismo craneal y accidentes cerebrovasculares hemorrágicos y/o isquémicos.…”

Section: Técnicas De Neuroimagen Estudios Neuroendocrinos: Defectos Funclassified

“…En algunos pacientes que se inyectan cocaína, se ha constatado el desarrollo de un cuadro fulminante de shock y coagulación intravascular diseminada. También es posible el desarrollo de una hipertermia maligna-like (13).…”

Section: Técnicas De Neuroimagen Estudios Neuroendocrinos: Defectos Funclassified

See 2 more Smart Citations

Cocaína: una revisión de la adicción y el tratamiento

Llona

Tumuluru

Torres

et al. 2015

Rev. Asoc. Esp. Neuropsiq.

View full text Add to dashboard Cite

Recibido: 17/09/2014; aceptado: 03/04/2015 RESUMEN: La cocaína es la droga responsable de más muertes en España. A pesar de una disminución del consumo en los últimos años, la prevalencia continúa siendo alta y es común hallarla en la práctica clínica. Si unimos a ello la peligrosidad del tóxico por su alta capacidad adictiva, las frecuentes y graves complicaciones que acarrea y la dificultad para su abandono, tenemos motivos de sobra para plantear una revisión tanto de su origen como de su estado actual, su abordaje clínico, y los retos para un futuro. PALABRAS CLAVE: cocaína, revisión, origen, adicción, tratamiento.ABSTRACT: Cocaine is the drug responsible for more deaths in Spain. Despite a decrease in consumption in recent years, the prevalence remains high and is common to find it in clinical practice. If you join it the danger of toxic because it´s addictive high capacity, frequent and serious complications involved and the difficulty of abandonment, we have every reason to propose a revision of both its origin and its present, its clinical approach, and challenges for the future. KEY WORDS: cocaine, review, origin, addiction, treatment. IntroducciónLa cocaína es una droga ilegal altamente consumida con graves consecuencias orgánicas, psiquiátricas y sociales. Aunque cada vez la información disponible es mayor, es probable que el abordaje del problema aún diste de ser el adecuado dada la frecuencia del consumo y de sus complicaciones. El DSM IV-TR recoge de forma extensa diferentes trastornos relacionados con ella, bien por el propio consumo (intoxicación, abuso o dependencia), o inducidos por él (abstinencia, delírium, psicosis, ansiedad y alteración del ánimo, del sueño o sexual).Es esencial conocer el contexto que envuelve al mundo de la droga y las consecuencias que acarrea para un mejor abordaje asistencial. EpidemiologíaEn la Unión Europea la cocaína es, tras el cannabis, la droga ilegal de mayor consumo entre los adultos jóvenes. Alrededor de 7,5 millones de jóvenes europeos

show abstract

Section: Técnicas De Neuroimagen Estudios Neuroendocrinos: Defectos Funclassified

See 1 more Smart Citation

Cocaína: una revisión de la adicción y el tratamiento

Llona

Tumuluru

Torres

et al. 2015

Rev. Asoc. Esp. Neuropsiq.

View full text Add to dashboard Cite

show abstract

“…Commonly abused substances like alcohol, the opioids, other sedatives, the stimulants, marijuana, or more exotic substances like hallucinogens, combinations, or socalled 'designer drugs,' synthetic cannabinoids, etc., have almost all been associated with either cognitive or neuronal dysfunction or laboratory-derived brain damage on mammals. [22][23][24][25][26][27][28][29][30][31].…”

Section: Cognitive Effects Of Drug Usementioning

confidence: 99%

HIV-Related Neurocognitive Disorders and Drugs of Abuse: Mired in Confound, Surrounded by Risk

Kennedy

Zerbo

2014

Curr Addict Rep

View full text Add to dashboard Cite

It has long been known that human immunodeficiency virus (HIV) uses the central nervous system (CNS) as a reservoir and nursery to replicate; therein, it does damage to cells and creates an inflammation that in turn allows for more virus to pass the blood-brain barrier. The inflammatory process itself can cause considerable damage. Neurocognitive disturbance from HIV infection is also known to occur at any stage of the infection. Likewise, common drugs of abuse also have adverse neurocognitive effects on their own. This review examines the literature available to try to elucidate the mechanisms of neurocognitive disorders in the HIV-infected individuals who have used drugs of abuse. Although the incidence of HIV-associated dementia (HAD) has decreased with the advent of highly active anti-retroviral therapy, less severe forms of neurocognitive impairment persist, even with supported immune systems and undetectable viral loads. Considerations for prevention are discussed.

show abstract

“…Growing evidence demonstrates that symptoms of HIVrelated neuropathology develop faster and are more severe in drug abusing HIV patients (Nath et al, 2002;Chander et al, 2006). Cocaine is a risk factor in NeuroAIDS (Nath et al, 2002;Fiala et al, 2005). Cocaine has been shown to increase HIV-1 invasion through brain blood barrier (Fiala et al, 2005) and to enhance neurotoxicity of HIV-1 proteins Tat and gp120 (Turchan et al, 2001;Kendall et al, 2005;.…”

Section: Introductionmentioning

confidence: 99%

Different effects of selective dopamine uptake inhibitors, GBR 12909 and WIN 35428, on HIV-1 Tat toxicity in rat fetal midbrain neurons

et al. 2008

View full text Add to dashboard Cite

Drug abuse is a risk factor for neurological complications in HIV infection. Cocaine has been shown to exacerbate HIV-associated brain pathology and enhance neurotoxicity of HIV-1 Tat and gp120 proteins. In this study, we found that the selective inhibitor of dopamine transporter (DAT) function, 1-[2-[bis(4-fluorophenyl) methoxy]ethyl]-4-(3-phenylpropyl) piperazine (GBR 12909, vanoxerine), but not the selective inhibitors of serotonin and norepinephrine (SERT and NET) transporters, sertraline and nizoxetine, emulated cocaine-mediated enhancement of Tat neurotoxicity in rat fetal midbrain primary cell cultures. Similar to cocaine, the significant increase of Tat toxicity in midbrain cell cultures was observed at micromolar dose (5 μM) of GBR 12909. However, different doses of another selective dopamine uptake inhibitor, WIN 35428 did not affect Tat neurotoxicity. The study supports the hypothesis that changes in control of dopamine (DA) homeostasis are important for the cocaine-mediated enhancement of HIV-1 Tat neurotoxicity. Our results also demonstrate that the inhibitors of DA uptake, which can bind to different domains of DAT, differ in their ability to mimic synergistic toxicity of cocaine and HIV-1 Tat in the midbrain cell culture.

show abstract

Cocaine increases human immunodeficiency virus type 1 neuroinvasion through remodeling brain microvascular endothelial cells

Cited by 77 publications

References 30 publications

Cocaína: una revisión de la adicción y el tratamiento

Cocaína: una revisión de la adicción y el tratamiento

HIV-Related Neurocognitive Disorders and Drugs of Abuse: Mired in Confound, Surrounded by Risk

Different effects of selective dopamine uptake inhibitors, GBR 12909 and WIN 35428, on HIV-1 Tat toxicity in rat fetal midbrain neurons

Contact Info

Product

Resources

About