Cocaine combined with heroin/morphine or ethanol disrupts mitochondrial and oxidative homeostasis

Untangling the Intracellular Mechanisms Underlying Toxicity of Drugs of Abuse: A Review of the Detrimental Effects of New Psychoactive Substances (NPS)

“…In agreement with several reports of clinical complications following co-abuse of NPS [4][5][6]8,9,13,[15][16][17][18], another relevant toxicokinetic expectation stems from the occurrence of drugdrug interactions, as several classic drugs [29][30][31][32][33][34][35] and some NPS [19,23,24] have already proved to drastically exacerbate each others' toxicity when combined, even at non-toxic single doses.…”