Cocaine abuse and effects in the serum levels of cytokines IL-6 and IL-10

Moreira, Fernanda Pedrotti; Medeiros, João Ricardo Carvalho; Lhullier, Alfredo Cardoso; Souza, Luciano Dias de Mattos; Jansen, Karen; Portela, Luis Valmor; Lara, Diogo R.; Silva, Ricardo Azevedo da; Wiener, Carolina David; Oses, Jean Pierre

doi:10.1016/j.drugalcdep.2015.11.024

Cited by 76 publications

(42 citation statements)

References 31 publications

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“…This process can justify the reduction of triglycerides and visceral fat area in the GOLD 3 group. Recently, IL-6/IL-10 ratio has been used as a good marker for degree inflammatory status with several diseases and conditions, such as AIDS, polytrauma, drugs abuse [41][42][43]. Thus, IL-6/IL-10 ratio could be an interesting strategy to prevent severity disease earlier.…”

Section: Discussionmentioning

confidence: 99%

Severity of COPD and its relationship with IL-10

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Severity of COPD and its relationship with IL-10

et al. 2018

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“…High secretion of IL-10 following partial activation of microglia following binge drinking has also been postulated to demonstrate the reparative role of microglia (Marshall et al, 2013). Interestingly, recent studies have also indicated attenuated basal levels of IL-10 in both early abstinent (Fox et al, 2012b) and actively using (Moreira et al, 2016) cocaine dependent individuals. Moreover, following three weeks of cocaine abstinence, a dampened IL-10 response was similarly observed following cocaine cue imagery compared with controls and concomitant to elevations in cocaine craving (Fox et al, 2012b).…”

Section: Discussionmentioning

confidence: 99%

Peripheral immune system suppression in early abstinent alcohol-dependent individuals: Links to stress and cue-related craving

et al. 2017

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Background Peripheral immune system cytokines may play an integral role in underlying sensitized stress response and alcohol craving during early withdrawal. To date, the nature of these immune changes during early abstinence have not been examined. Methods Thirty-nine early abstinent, treatment-seeking alcohol dependent individuals and 46 socially drinking controls were exposed to three guided imageries: stress, alcohol cue and neutral. These were presented randomly across consecutive days. Plasma measures of tumor necrosis factor alpha (TNFα), tumor necrosis factor receptor 1 (TNFR1), interleukin-6 (IL-6), and interleukin-10 (IL-10), were collected at baseline, immediately after imagery and at various recovery time-points. Ratings of alcohol craving, negative mood and anxiety were also obtained at the same time-points. Results The alcohol group demonstrated decreased basal IL-10 compared with controls particularly following exposure to alcohol cue. They also showed a dampened TNFα and TNFR1 response to stress and cue, respectively, and a generalized suppression of IL-6. In the alcohol group, these immune system adaptations occurred alongside significant elevations in anxiety, negative mood and alcohol craving. Conclusions Findings demonstrate that broad immuno-suppression is still observed in alcohol dependent individuals after three weeks of abstinence and may be linked to motivation for alcohol.

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“…Several attempts have been made to identify these possible biomarkers by exploring accessible signaling compartments (i.e., blood) or functional neuropsychological tests. Among these attempts, recent studies have identified circulating factors involved in immune function as potential biomarkers in CUD and other substance use disorders ( Araos et al, 2015 ; Moreira et al, 2016 ; García-Marchena et al, 2017a ). These and other studies have demonstrated that abused drugs interact with the immune system and alter signaling and gene expression involved in the immune response, which these effects contribute to various aspects of addiction ( Cui, Shurtleff & Harris, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of plasma cytokines in patients with cocaine use disorders in abstinence identifies transforming growth factor alpha (TGFα) as a potential biomarker of consumption and dual diagnosis

Maza-Quiroga

García-Marchena

Romero-Sanchiz

et al. 2017

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BackgroundCocaine use disorder (CUD) is a complex health condition, especially when it is accompanied by comorbid psychiatric disorders (dual diagnosis). Dual diagnosis is associated with difficulties in the stratification and treatment of patients. One of the major challenges in clinical practice of addiction psychiatry is the lack of objective biological markers that indicate the degree of consumption, severity of addiction, level of toxicity and response to treatment in patients with CUD. These potential biomarkers would be fundamental players in the diagnosis, stratification, prognosis and therapeutic orientation in addiction. Due to growing evidence of the involvement of the immune system in addiction and psychiatric disorders, we tested the hypothesis that patients with CUD in abstinence might have altered circulating levels of signaling proteins related to systemic inflammation.MethodsThe study was designed as a cross-sectional study of CUD treatment-seeking patients. These patients were recruited from outpatient programs in the province of Malaga (Spain). The study was performed with a total of 160 white Caucasian subjects, who were divided into the following groups: patients diagnosed with CUD in abstinence (N = 79, cocaine group) and matched control subjects (N = 81, control group). Participants were clinically evaluated with the diagnostic interview PRISM according to the DSM-IV-TR, and blood samples were collected for the determination of chemokine C-C motif ligand 11 (CCL11, eotaxin-1), interferon gamma (IFNγ), interleukin-4 (IL-4), interleukin-8 (IL-8), interleukin-17α (IL-17α), macrophage inflammatory protein 1α (MIP-1α) and transforming growth factor α (TGFα) levels in the plasma. Clinical and biochemical data were analyzed in order to find relationships between variables.ResultsWhile 57% of patients with CUD were diagnosed with dual diagnosis, approximately 73% of patients had other substance use disorders. Cocaine patients displayed greater cocaine symptom severity when they were diagnosed with psychiatric comorbidity. Regarding inflammatory factors, we observed significantly lower plasma levels of IL-17α (p < 0.001), MIP-1α (p < 0.001) and TGFα (p < 0.05) in the cocaine group compared with the levels in the control group. Finally, there was a significant primary effect of dual diagnosis on the plasma concentrations of TGFα (p < 0.05) in the cocaine group, and these levels were lower in patients with dual diagnosesDiscussionIL-17α, MIP-1α and TGFα levels are different between the cocaine and control groups, and TGFα levels facilitate the identification of patients with dual diagnosis. Because TGFα reduction is associated with enhanced responses to cocaine in preclinical models, we propose TGFα as a potential biomarker of complex CUD in humans.

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Cocaine abuse and effects in the serum levels of cytokines IL-6 and IL-10

Cited by 76 publications

References 31 publications

Severity of COPD and its relationship with IL-10

Severity of COPD and its relationship with IL-10

Peripheral immune system suppression in early abstinent alcohol-dependent individuals: Links to stress and cue-related craving

Evaluation of plasma cytokines in patients with cocaine use disorders in abstinence identifies transforming growth factor alpha (TGFα) as a potential biomarker of consumption and dual diagnosis

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