Cobalt single atom sites in carbon aerogels for ultrasensitive enzyme-free electrochemical detection of glucose

Single-atom nanozymes as promising catalysts for biosensing and biomedical applications

“…In a recent study, 117 following the previous procedure for the preparation of NCAG/Fe, we synthesized a Co SAzyme based on the similarly structured N-doped carbon aerogels. Again, the gelatin-zinc hydrogel was adopted as the precursor, into which were added a Co-PM complex and SiO 2 nanoparticles.…”

Single‐Atom Materials as Electrochemical Sensors: Sensitivity, Selectivity, and Stability

“…Nitrogen is the most popular heteroatom for carbon doping due to its strong MÀ N coordination, where N sites act as the Lewis base. Various SAMs sensors have been developed using N-doped carbon (denoted as NÀ C) as the conductive support, including mainly NiÀ NÀ C (representing Ni atoms supported on N-doped carbon, same below), [16] FeÀ NÀ C, [17][18] CoÀ NÀ C, [19][20][21][22] and CuÀ NÀ C. [23] As a result of the characteristic MÀ N coordination, a diverse reaction path and energy requirements are generally found for MÀ NÀ C composites compared to metal nanomaterials. A lower energy barrier is often reported for those with much higher sensitivity (or lower LOD) than conventional sensors.…”

Surface charge modulation enhanced high stability of gold oxidation intermediates for electrochemical glucose sensors

“…9 In contrast, enzyme-free sensors can overcome these drawbacks and enable continuous glucose monitoring. In recent years, various nanomaterials have been developed and applied for electrochemical detection of glucose, including noble metals (Au, 10–12 Ag, 13 and Pt 14 ), transition metals (Cu, 15 Co, 16 and Ni 17 ) and their oxides (CuO, 18 Cu 2 O, 19,20 Co 3 O 4 , 21 and NiO 22,23 ) and sulfides (CuS, 24 Co 3 S 4 , 25 CoS, 26 and NiS 27 ), carbon nanomaterials, 28 etc. Among them, the noble metal Au has been proven to have excellent activity and biocompatibility.…”