“…3-(1,2,3-Triazolyl)-β- d -thiogalactosides have also been reported (Table , entry 26) and provided inhibitors with micromolar K d values . Another strategy used alkylation at the 3-position of galactose , (Table , entries 27,28) or 3′-position of LacNAc (Table , entry 29) with hydrophobic benzyl ethers leading to moderate to strong enhancement of affinities toward both Gal-1 and -3. Nevertheless, the LacNAc scaffold with an additional hydrophobic phthalimido substituent at the 2-position provided the best results not only in terms of affinity but also in terms of selectivity between Gal-1 and -3 (more than 230 in favor of Gal-3), which is another challenge in such drug design approaches.…”