Cobalt-mediated oxidative DNA damage and its prevention by polyphenol antioxidants

Angelé-Martínez, Carlos; Murray, Joseph A.; Stewart, Paul; Haines, J. L.; Gaertner, Andrea A.E.; Brumaghim, Julia L.

doi:10.1016/j.jinorgbio.2022.112024

Cited by 3 publications

(1 citation statement)

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“…In addition to nitrogen xation in leguminous plants, cobalt has no other direct biological or physiological role (Hu et al 2021). However, it is important to note that elevated levels of Co can lead to DNA damage via oxidative stress (Angelé- Martínez et al 2023). Moreover, they can damage cells, increase the production of ROS in plants, alter enzymatic activity, impede the absorption of vital nutrients, including phosphorus, sulfur, iron, calcium, manganese, zinc, and copper; hinder photosynthesis; disrupt stomatal conductance, carbon uptake, transpiration rate, chlorosis, and necrosis; and induce chlorosis and necrosis (Sachdev et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Impact of cobalt and zinc stress on Rehmannia glutinosa growth, bioactive compound production, antioxidant activity, and molecular dynamics simulation

Ghimire,

Alharbi,

Kadaikunnan

et al. 2024

Preprint

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The effects of cobalt (Co) and zinc (Zn) on the growth of Rehmannia glutinosa, as well as its antioxidant activity, total phenolic and flavonoid contents (TPC and TFC), targeted polyphenolic compounds, and molecular dynamics simulations were studied. The results revealed that exposure to 0.01 to 0.1 ppm Zn in the growth medium increased plant height, average number of leaves, and root length. Higher concentrations of Zn had deleterious effects, and lower concentrations of Co (0.01 and 0.1 ppm) significantly inhibited growth, as indicated by the retardation and reduction in root length, plant height, and leaf numbers. Higher concentrations of Co (1 ppm) cause early defoliation, necrosis, and plant death. The highest concentration of Zn (1 ppm) caused a significant decrease in Chl a concentration compared to the other concentrations and the control plants. Lower concentrations of Zn and Co (0.01 ppm) showed elevated radical-scavenging activity compared with that of the control plants. Maximum TPC and TFC were achieved at 0.01 ppm of Zn, while a higher concentration of TPC and TFC was obtained with 0.1 ppm of Co. Furthermore, catalase and ascorbate peroxidase activity were significantly affected by Zn and Co. The targeted phenolic compounds were analyzed by LC-MS-MS in the Zn- and Co-treated and control plants. Finally, to evaluate the stability of phytochemicals with high binding affinities and docking scores, a 100-ns molecular dynamic simulation was performed. These findings suggest that exposure to high concentrations of Zn- and Co-contaminated soils may affect the growth and metabolism of R. glutinosa.

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Section: Introductionmentioning

confidence: 99%