Cobalt(II) complexes with pyridine and 5-[(<i>E</i>)-2-(aryl)-1-diazenyl]-quinolin-8-olates: synthesis, electrochemistry and X-ray structural characterization

Baul, Tushar S. Basu; Nongsiej, Khrawborlang; Rocha, Bruno G. M.; Silva, M. Fátima C. Guedes da

doi:10.1080/00958972.2018.1506876

Cited by 4 publications

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“…The UV–vis spectra of the Co(II) complexes showed one major absorption band in the range of 400–700 nm, consistent with previously reported high-spin octahedral Co(II) complexes (Table and Figure S5). All the [Co(TPA)(MBI)] + complexes showed a similar range of absorption wavelength maxima (483–486 nm), which was slightly shifted from the value for [Co(TPA)(pic)] + (493 nm).…”

Section: Resultsmentioning

confidence: 83%

“…The UV−vis spectra of the Co(II) complexes showed one major absorption band in the range of 400−700 nm, consistent with previously reported high-spin octahedral Co(II) complexes (Table 4 and Figure S5). 49 All the [Co(TPA)(MBI)] + complexes showed a similar range of absorption wavelength maxima (483−486 nm), which was slightly shifted from the value for [Co(TPA)(pic)] + (493 nm). Finally, spectroscopic characterization of the [(Tp Ph,Me )Co-(MBI)] complexes was performed to further understand the electronic difference between MBIs, pic, and bpy in the model systems.…”

Section: ■ Results and Discussionmentioning

confidence: 86%

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Evaluating Metal–Ligand Interactions of Metal-Binding Isosteres Using Model Complexes

et al. 2021

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Bioisosteres are a useful approach to address pharmacokinetic liabilities and improve drug-like properties. Specific to developing metalloenzyme inhibitors, metal-binding pharmacophores (MBPs) have been combined with bioisosteres, to produce metal-binding isosteres (MBIs) as alternative scaffolds for use in fragment-based drug discovery (FBDD). Picolinic acid MBIs have been reported and evaluated for their metal-binding ability, pharmacokinetic properties, and enzyme inhibitory activity. However, their structural, electronic, and spectroscopic properties with metal ions other than Zn(II) have not been reported, which might reveal similarities and differences between MBIs and the parent MBPs. To this end, [M(TPA)(MBI)]+ (M = Ni(II) and Co(II), TPA = tris(2-pyridylmethyl)amine) is presented as a bioinorganic model system for investigating picolinic acid, four heterocyclic MBIs, and 2,2′-bipyridine. These complexes were characterized by X-ray crystallography as well as NMR, IR, and UV–vis spectroscopies, and their magnetic moments were accessed. In addition, [(TpPh,Me)Co(MBI)] (TpPh,Me = hydrotris(3,5-phenylmethylpyrazolyl)borate) was used as a second model compound, and the limitations and attributes of the two model systems are discussed. These results demonstrate that bioinorganic model complexes are versatile tools for metalloenzyme inhibitor design and can provide insights into the broader use of MBIs.

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Section: Resultsmentioning

confidence: 83%

Section: ■ Results and Discussionmentioning

confidence: 86%