Cobalt(II) chloride catalyzed normal pressure carbonylation of aryl halides

First-Row Transition-Metal-Catalyzed Carbonylative Transformations of Carbon Electrophiles

“…Related results were reviewed by Foa and Francalanci . The same group performed excellent studies on this topic, for instance reporting a cobalt-catalyzed double carbonylation of aryl and secondary benzyl halides. , The reaction proceeded in alcoholic solvent in the presence of a catalytic amount of Co 2 (CO) 8 , providing corresponding acids in moderate yields and selectivity under an atmospheric pressure of CO. Studies on cobalt-catalyzed carbonylation of aryl and benzyl halides have also been performed in other research groups. − Kashimura’s group developed a cobalt-catalyzed photostimulated carbonylation of o -halogenated benzoic acids in aqueous sodium hydroxide . Miura and co-workers succeeded in the cobalt-catalyzed carbonylation of vinyl halides.…”

Chemoselectivity of cobalt-catalysed carbonylation—A reliable platform for the synthesis of fluorinated benzoic acids

“…The reaction occurs in the presence of tetracarbonylcobaltate anion and corresponds to the S N 2 mechanism [1][2][3][4]. The activation of aryl halides requires special techniques, including the UV irradiation, the system enrichment with a one-electron reducing agent, or the modification of the Co(CO) 4 À anion [5][6][7][8][9][10][11][12][13][14]. All these early studies demonstrate the ability of the Co(CO) 4 À anion to be an efficient catalyst for the carbonylation of aryl halides in conditions that provide the anion-radical synthetic pathway.…”