Cobalt(II) Catalyzed Tosylation of Alcohols with p‐Toluenesulfonic Acid.

Velusamy, Subbarayan; Kumar, Jithan; Punniyamurthy, Tharmalingam

doi:10.1002/chin.200414073

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“…Compounds 35 and 36 were used for tosylation yielding 2-(tosyloxy)ethyl ester TOE@SNAP 3 and 3-(tosyloxy)propyl ester TOP@SNAP 5, respectively. Since common tosylation methods [30][31][32] were not applicable, tosylation was achieved using silver oxide and tosyl chloride in the presence of potassium iodide adapting a method of Bouzide et al [33]. Comparing the yields, TOE@SNAP 3 was obtained with 63%, whereas the tosylpropyl derivative 5 gave a poorer 31% yield (Scheme 12).…”

Section: Scheme 8 Synthesis Of Hydroxylethyl and Hydroxypropyl Estermentioning

confidence: 99%

Syntheses of Precursors and Reference Compounds of the Melanin-Concentrating Hormone Receptor 1 (MCHR1) Tracers [11C]SNAP-7941 and [18F]FE@SNAP for Positron Emission Tomography

et al. 2013

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Abstract:The MCH receptor has been revealed as a target of great interest in positron emission tomography imaging. The receptor′s eponymous substrate melanin-concentrating hormone (MCH) is a cyclic peptide hormone, which is located predominantly in the hypothalamus with a major influence on energy and weight regulation as well as water balance and memory. Therefore, it is thought to play an important role in the pathophysiology of adiposity, which is nowadays a big issue worldwide. Based on the selective and high-affinity MCH receptor 1 antagonist SNAP-7941, a series of novel SNAP derivatives has been developed to provide different precursors and reference compounds for the radiosyntheses of the novel PET radiotracers [ Positron emission tomography promotes a better understanding of physiologic parameters on a molecular level, thus giving a deeper insight into MCHR1 related processes as adiposity.

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Section: Scheme 8 Synthesis Of Hydroxylethyl and Hydroxypropyl Estermentioning

confidence: 99%