Cobalt ferrite nanoparticles: The control of the particle size and surface state and their effects on magnetic properties

Baldi, Giovanni; Bonacchi, Daniele; Innocenti, Claudia; Lorenzi, Giada; Sangregorio, Claudio

doi:10.1016/j.jmmm.2006.11.157

Cited by 193 publications

(102 citation statements)

References 19 publications

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“…2 As a consequence of their small size, 3 mechanical hardness, and heat generation potential, 4 cobalt ferrite (CoFe 2 O 4 ) NPs have been one of the most extensively investigated magnetic NPs for medical purposes. 5 With enhanced anisotropy and saturation magnetization, CoFe 2 O 4 meets the criteria for a useful material in magnetic hyperthermia-induced cancer treatment based on an increase in temperature at the heat center of the NP upon interaction with an alternating magnetic field. 6 A better understanding of the interactions between magnetic NPs and membranes can be achieved by assessment of their biocompatibility when used as potential diagnostic and therapeutic agents.…”

Section: Introductionmentioning

confidence: 99%

Effects of magnetic cobalt ferrite nanoparticles on biological and artificial lipid membranes

Drašler¹,

Drobne²,

Novak³

et al. 2014

IJN

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Background The purpose of this work is to provide experimental evidence on the interactions of suspended nanoparticles with artificial or biological membranes and to assess the possibility of suspended nanoparticles interacting with the lipid component of biological membranes. Methods 1-Palmitoyl-2-oleoyl- sn -glycero-3-phosphocholine (POPC) lipid vesicles and human red blood cells were incubated in suspensions of magnetic bare cobalt ferrite (CoFe 2 O 4 ) or citric acid (CA)-adsorbed CoFe 2 O 4 nanoparticles dispersed in phosphate-buffered saline and glucose solution. The stability of POPC giant unilamellar vesicles after incubation in the tested nanoparticle suspensions was assessed by phase-contrast light microscopy and analyzed with computer-aided imaging. Structural changes in the POPC multilamellar vesicles were assessed by small angle X-ray scattering, and the shape transformation of red blood cells after incubation in tested suspensions of nanoparticles was observed using scanning electron microscopy and sedimentation, agglutination, and hemolysis assays. Results Artificial lipid membranes were disturbed more by CA-adsorbed CoFe 2 O 4 nanoparticle suspensions than by bare CoFe 2 O 4 nanoparticle suspensions. CA-adsorbed CoFe 2 O 4 -CA nanoparticles caused more significant shape transformation in red blood cells than bare CoFe 2 O 4 nanoparticles. Conclusion Consistent with their smaller sized agglomerates, CA-adsorbed CoFe 2 O 4 nanoparticles demonstrate more pronounced effects on artificial and biological membranes. Larger agglomerates of nanoparticles were confirmed to be reactive against lipid membranes and thus not acceptable for use with red blood cells. This finding is significant with respect to the efficient and safe application of nanoparticles as medicinal agents.

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Section: Introductionmentioning

confidence: 99%

Effects of magnetic cobalt ferrite nanoparticles on biological and artificial lipid membranes

Drašler¹,

Drobne²,

Novak³

et al. 2014

IJN

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“…[769] Furthermore, other metals such as manganese [770] and cobalt [771] have been added to iron oxide nanoparticles to increase their contrast-enhancing efficiency by gaining superior magnetic anisotropy, [772] as well reducing the particle size for longer blood circulation times. [773] Simultaneously, PET signals are in charge of resolving the lack of functional information provided by MR images. [774] The high sensitivity of PET imaging, down to the pico-molar level deposited in the living subjects, [775] combined with its no penetration limit come in handy for numerous in vivo diagnostic applications.…”

Section: Positron Emission Tomographymentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

185

168

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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“…Regions of interest were analyzed using ImageJ software (available online from http://imagej.nih.gov/ij/). 38 The heat generated by the intratumorally injected nanoparticle dispersions was measured when the A431-bearing mice were placed at the center of the coil, which induces the magnetic field. The coil has 3 turns, 4.2 cm height and a diameter of 10 cm, which allows the entire animal to be placed inside.…”

Section: Mouse Modelmentioning

confidence: 99%

“…For synthesis of poly(D,L-lactide-co-glycolide)-(PLGA)-b-PEG-COOH, the carboxyl-capped PLGA-COOH was activated with N-hydroxysuccinimide using dicyclohexylcarbodiimide coupling chemistry and then conjugated to the carboxylic aminodifunctional PEG in chloroform and in the presence of diisopropylethylamine. [40][41][42] The lipophilic Fe 3 O 4 -1 was then entrapped into the PLGA-b-PEG-COOH using the nanoprecipitation technique [40][41][42][43] as reported in Figure 1, giving Fe 3 O 4 -1-PNPs. For nanoprecipitation, we selected acetone as the solvent and used an acetone to water ratio of 1/10 and a polymer concentration of 2.5 mg/mL in a cetone; after purification and concentration, we obtained 40 mL of a 10.0 mg/mL colloidal suspension in water relative to the iron oxide, evaluated by inductively coupled plasma mass spectrometry.…”

mentioning

confidence: 99%

In vivo anticancer evaluation of the hyperthermic efficacy of anti-human epidermal growth factor receptor-targeted PEG-based nanocarrier containing magnetic nanoparticles

Baldi¹,

Ravagli²,

Mazzantini³

et al. 2014

IJN

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Polymeric nanoparticles with targeting moieties containing magnetic nanoparticles as theranostic agents have considerable potential for the treatment of cancer. Here we report the chemical synthesis and characterization of a poly(D,L-lactide- co -glycolide)- b -poly(ethylene glycol)-based nanocarrier containing iron oxide nanoparticles and human epithelial growth factor receptor on the outer shell. The nanocarrier was also radiolabeled with 99m Tc and tested as a theranostic nanomedicine, ie, it was investigated for both its diagnostic ability in vivo and its therapeutic hyperthermic effects in a standard A431 human tumor cell line. Following radiolabeling with 99m Tc, the biodistribution and therapeutic hyperthermic effects of the nanosystem were studied noninvasively in vivo in tumor-bearing mice. A substantial decrease in tumor size correlated with an increase in both nanoparticle concentration and local temperature was achieved, confirming the possibility of using this multifunctional nanosystem as a therapeutic tool for epidermoid carcinoma.

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Cobalt ferrite nanoparticles: The control of the particle size and surface state and their effects on magnetic properties

Cited by 193 publications

References 19 publications

Effects of magnetic cobalt ferrite nanoparticles on biological and artificial lipid membranes

Effects of magnetic cobalt ferrite nanoparticles on biological and artificial lipid membranes

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

In vivo anticancer evaluation of the hyperthermic efficacy of anti-human epidermal growth factor receptor-targeted PEG-based nanocarrier containing magnetic nanoparticles

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